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Kinetic study for solid-state degradation of mental disorder therapeutic agents

Amitriptyline, desipramine and imipramine

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Abstract

This paper describes the thermal investigations and kinetic analysis regarding the solid-state degradation of three compounds used as mental disorder therapeutic agents (antidepressants), namely amitriptyline, desipramine and imipramine. The study was carried according to ICTAC 2000 recommendations, by using three isoconversional methods, namely Flynn–Wall–Ozawa, Kissinger–Akahira–Sunose and Friedman. The differential method of Friedman indicated multistep degradation, which was later confirmed by the nonparametric kinetic method (NPK). NPK method showed that all three tricyclic antidepressants are degraded by two processes. In terms of apparent activation energies for decomposition, the NPK method indicated 123.4 kJ mol−1 for imipramine, 112.3 kJ mol−1 for desipramine and 82.9 kJ mol−1 for amitriptyline, and the results are in good agreement with the ones suggested by isoconversional methods.

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Abbreviations

α :

Conversion degree

T :

Temperature

f(α):

Differential conversion function

g(α):

Integral conversion function

R :

Universal gas constant

β :

Heating rate and β = dT/dt (where t is time)

k(T):

A temperature dependence

A :

Pre-exponential factor

E a :

Activation energy given by the Arrhenius equation

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Acknowledgements

This work was supported by the PN-II-RU-TE-2014-4-0515 to Adriana Ledeţi, Gabriela Vlase and Ionuţ Ledeţi.

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Authors and Affiliations

  1. Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041, Timisoara, Romania

    Adriana Ledeti, Gabriela Vlase, Denisa Circioban, Cristina Dehelean & Ionut Ledeti

  2. Research Center for Thermal Analysis in Environmental Problems, Faculty of Chemistry-Biology-Geography, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

    Titus Vlase & Denisa Circioban

Authors
  1. Adriana Ledeti
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Correspondence to Ionut Ledeti.

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Ledeti, A., Vlase, G., Vlase, T. et al. Kinetic study for solid-state degradation of mental disorder therapeutic agents. J Therm Anal Calorim 131, 155–165 (2018). https://doi.org/10.1007/s10973-016-6064-8

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