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Mesoporous silica materials functionalized with folic acid: preparation, characterization and release profile study with methotrexate

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Abstract

Ordered mesoporous silica materials exhibit potential features to be used as controlled drug delivery systems, including biocompatibility, textural and structural properties. In this paper, ordered mesoporous materials SBA-15, SBA-16 and MCM-41, which present different morphologies, pore sizes and array of mesopores (2D hexagonal, 3D cubic and 2D hexagonal, respectively), were synthesized, functionalized with folic acid by post-synthesis grafting and loaded with the anticancer agent methotrexate. The drug loading and its release kinetics profile were compared between all materials. The mesoporous silicas were characterized through thermogravimetric analysis, CHN elemental analysis, Fourier transform infrared spectroscopy, small-angle X-ray scattering, N2 adsorption, zeta potential, scanning electron microscopy and transmission electron microscopy in order to evaluate their physical–chemical properties. The interactions between methotrexate and the materials’ surface were systematically evaluated using X-ray photoelectron spectroscopy. The results showed the drug release kinetic might be controlled by the synthesis procedure and the degree of surface functionalization of the mesoporous silica.

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Acknowledgments

The authors would like to thank FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais), CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) for all financial support, and the Microscopy Center of the Federal University of Minas Gerais, Belo Horizonte, Brazil (http://www.microscopia.ufmg.br).

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  1. Laboratório de Materiais Nanoestruturados para Bioaplicações, Comissão Nacional de Energia Nuclear – Centro de Desenvolvimento da Tecnologia Nuclear – (CNEN/CDTN), Av. Presidente Antônio Carlos 6.627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil

    Luiza Baptista de Oliveira Freitas, Ismael José Gonzalez Bravo, Waldemar Augusto de Almeida Macedo & Edésia Martins Barros de Sousa

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  1. Luiza Baptista de Oliveira Freitas
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Correspondence to Edésia Martins Barros de Sousa.

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Freitas, L.B.O., Bravo, I.J.G., Macedo, W.A.A. et al. Mesoporous silica materials functionalized with folic acid: preparation, characterization and release profile study with methotrexate. J Sol-Gel Sci Technol 77, 186–204 (2016). https://doi.org/10.1007/s10971-015-3844-8

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