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Aminosilane as an effective binder for hydroxyapatite-gelatin nanocomposites

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Abstract

Aminosilane has been explored as an alternative chemical linker to facilitate the binding and solidification of hydroxyapatite-gelatin nanocomposite at room temperature, which was synthesized using co-precipitation method in the presence of gelatin. This aminosilane treatment was found effective at low concentration (~25 μL/mL) and the solidification and dehydration of hydroxyapatite-gelatin slurry completes within hours depending on the amount of aminosilane. The resulting sample exhibits compressive strength of 133 MPa, about 40% higher than glutaraldehyde treated samples, and shows good biocompatibility based on cell adhesion, proliferation, alkaline phosphate synthesis, and mineralization studies.

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Acknowledgments

This work is supported, in part, by, NC Biotech Center Grant#2008-MRG-1108. CCK also thanks NIDCR K08DE018695 and American Association of Orthodontists Foundation for their financial support.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, North Carolina State University, Raleigh, NC, 27695, USA

    Tzy-Jiun M. Luo, Chi-Kai Chiu, Jacob Llyod & Uk Huh

  2. Department of Orthodontics, University of North Carolina, Chapel Hill, NC, 27599-7450, USA

    Ching-Chang Ko

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  1. Tzy-Jiun M. Luo
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Correspondence to Tzy-Jiun M. Luo.

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Luo, TJ.M., Ko, CC., Chiu, CK. et al. Aminosilane as an effective binder for hydroxyapatite-gelatin nanocomposites. J Sol-Gel Sci Technol 53, 459–465 (2010). https://doi.org/10.1007/s10971-009-2114-z

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  • DOI: https://doi.org/10.1007/s10971-009-2114-z

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