Abstract
Purpose
To compare the IVF outcomes of vitrification-thawed blastocyst transfer cycles utilizing different endometrial preparation methods.
Methods
We retrospectively assessed IVF outcomes in 611 patients (648 cycles) who underwent blastocyst frozen embryo transfer (FET) between January 2007 and December 2009. All embryos had been cryopreserved by a vitrification method following a previous IVF cycle. Patients were prepared for transfer by using either the natural cycle (n = 310/Group 1), the natural cycle with ovulation induction employing human chorionic gonadotropin (n = 134/Group 2), or a hormonally manipulated artificial cycle with estrogen and progesterone supplementation (n = 204/Group 3).
Results
Multivariate logistic regression analysis showed a significant difference in clinical pregnancy rate between Groups 3 (30.4%) and 1 (41.9%) (odds ratio [OR], 0.567; 95% confidence interval [CI], 0.379–0.847, P = 0.006) whereas the difference between Groups 2 and 1 was not significant (41.8% vs. 41.9%; OR, 0.683; 95% CI, 0.435–1.073; P = 0.098). Other significant variables affecting clinical pregnancy rate were the number of embryos transferred, the grade of transferred embryos, and maximal endometrial thickness.
Conclusion
The results showed that, using vitrification-thawed blastocyst transfer, employment of natural cycles with or without hCG treatment was associated with better outcomes than was the use of hormonally manipulated cycles.
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Acknowledgements
This study was supported by a grant (no. A084923) from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea.
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During vitrified-thawed blastocyst transfer, the use of natural cycles with or without hCG treatment resulted in more favorable IVF outcomes than were noted when hormonally manipulated cycles were employed.
Presented at the 66th Annual Meeting of the American Society for Reproductive Medicine, Denver, CO, on October 24, 2010.
Woo Sik Lee and Tae Ki Yoon contributed equally to this work.
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Chang, E.M., Han, J.E., Kim, Y.S. et al. Use of the natural cycle and vitrification thawed blastocyst transfer results in better in-vitro fertilization outcomes. J Assist Reprod Genet 28, 369–374 (2011). https://doi.org/10.1007/s10815-010-9530-4
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DOI: https://doi.org/10.1007/s10815-010-9530-4