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Mycophenolate Mofetil Has Potent Anti-inflammatory Actions in a Mouse Model of Acute Lung Injury

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Abstract

Septic shock is a systemic inflammatory response syndrome, and it is the leading cause of death in intensive care units. Mycophenolate mofetil (MMF) is an immunosuppressant that has been shown to be effective in the treatment of various inflammatory diseases. In this study, the anti-inflammatory effect of MMF in a mouse model of acute lung injury (ALI) induced by lipopolysaccharide (LPS) was evaluated. ALI was induced by intrapleural injection of LPS (250 ng/cavity). The leukocyte migration, exudation, myeloperoxidase and adenosine deaminase activities, nitric oxide products, tumor necrosis factor alpha (TNF-α), and interleukin 1 beta (IL-1β) levels, as well as mRNA expression of TNF-α and IL-1β, were evaluated. This study showed that MMF significantly decreased all parameters studied in a manner comparable to treatment with dexamethasone. In conclusion, MMF has important anti-inflammatory effects that may be useful as an auxiliary treatment for septic shock.

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Authors and Affiliations

  1. Department of Medicine, Centre of Health Sciences, Regional University of Blumenau, Campus Universitário-Itoupava Seca, 89030-000, Blumenau, SC, Brazil

    M. G. Beduschi

  2. Department of Phamaceutical Science, Centre of Health Sciences, Regional University of Blumenau, Campus Universitário-Itoupava Seca, 89030-000, Blumenau, SC, Brazil

    C. L. Guimarães

  3. Department of Clinical Analyses, Centre of Health Sciences, Federal University of Santa Catarina, Campus Universitário-Trindade, 88040-970, Florianopolis, SC, Brazil

    Z. S. Buss & E. M. Dalmarco

Authors
  1. M. G. Beduschi
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  2. C. L. Guimarães
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  3. Z. S. Buss
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  4. E. M. Dalmarco
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Correspondence to E. M. Dalmarco.

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Beduschi, M.G., Guimarães, C.L., Buss, Z.S. et al. Mycophenolate Mofetil Has Potent Anti-inflammatory Actions in a Mouse Model of Acute Lung Injury. Inflammation 36, 729–737 (2013). https://doi.org/10.1007/s10753-013-9599-x

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  • DOI: https://doi.org/10.1007/s10753-013-9599-x

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