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Study on the damage of sperm induced by nickel nanoparticle exposure

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Abstract

As a new type of nanomaterials, nickel nanoparticles (Ni NPs) have been widely used by human beings, whose exposure probability was greatly increasing. Many studies have shown that Ni NPs can induce apoptosis, oxidative stress and DNA damage. Nowadays, male reproductive health is an important public health problem, which is a hot topic in toxicological research. In the present study, to protect reproductive health, the effect of Ni NPs exposure on spermatogenesis injury was assessed, understanding the toxicity and safety of Ni NPs. Sixty ICR male mice with 20 ± 2 g were randomly divided into five groups. The experimental groups were treated with 5 mg/kg, 15 mg/kg and 45 mg/kg Ni NPs. The reproductive toxicity of Ni NPs on male mice was evaluated by the indexes of testicular organ coefficient, testicular marker enzyme, sperm motility and histopathology. As a result, the somatic index of testis and epididymis increased in each group. Compared with the control group, the activity of testicular markers increased and the sperm motility index decreased in the low-, middle- and high-dose groups. Pathological results indicated that various cell apoptosis and disordered arrangement of cells occurred in the seminiferous tubules of the exposed groups. In conclusion, the findings of this study suggest that Ni NPs have certain damage to spermatogenesis in mice.

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Acknowledgements

The authors thank the support from the National Natural Science Foundation (Nos. 81502783, 21876026, 31671034).

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Authors and Affiliations

  1. Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nan**g, 210009, China

    Wangcheng Hu, Zhou Yu, **aojie Gao, Yongya Wu, Meng Tang & Lu Kong

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  1. Wangcheng Hu
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Correspondence to Lu Kong.

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Hu, W., Yu, Z., Gao, X. et al. Study on the damage of sperm induced by nickel nanoparticle exposure. Environ Geochem Health 42, 1715–1724 (2020). https://doi.org/10.1007/s10653-019-00364-w

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