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Investigational agents in development for the treatment of ovarian cancer

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Summary

Although significant success has been achieved in the treatment of advanced and recurrent ovarian cancer, there is clearly room for improvement. The use of targeted agents in this patient population has the promise to provide improved survival and quality of life. There are a myriad of relevant pathways under exploration in all settings of ovarian cancer. Clinical trial data are accumulating for antiangiogenic therapy, including vascular endothelial growth factor (VEGF)-specific inhibitors and multiple angiogenic signaling target inhibitors, as well as poly-ADP-ribose polymerase (PARP) inhibitors. Other types of tumorigenic pathway inhibitors, including those that target phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR), protein kinase B (AKT), Src, folate receptor alpha, and insulin-like growth factor-1 receptor (IGF-1R) pathways are in earlier phases of development for ovarian cancer. Attempts to target the epidermal growth factor receptor (EGFR) of ovarian tumors have been met with limited success; however, newer agents that inhibit this pathway show promise. Finally, with recognition of the role of Wee-1 in p53-deficient tumors, an inhibitor of this tyrosine kinase is being evaluated in recurrent ovarian cancer. The logistical challenge is to determine the optimal timing and proper combinations of novel agents independently as well as concomitantly with conventional chemotherapeutics. Reported results have been modest; however, our growing understanding of these pathways will be potentially reflected in greater impact on response and survival.

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Acknowledgments

This work was supported by Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI). Writing and editorial assistance was provided by Lisa Shannon, PharmD, of MedErgy, which was contracted by BIPI for these services. The authors meet criteria for authorship as recommended by the International Committee of Medical Journal Editors (ICMJE), were fully responsible for all content and editorial decisions, and were involved at all stages of manuscript development. The authors received no compensation related to the development of the manuscript.

Conflict of interest

Dr. Westin serves on the scientific advisory board for OCT, Inc. Dr. Herzog has served on advisory boards for Morphotek, Inc, Nektar Therapeutics, Roche, Endocyte, and Johnson & Johnson. Dr. Coleman serves on the scientific steering committees and/or receives research funding from Morphotek, Inc, Nektar Therapeutics, Roche/Genentech, Johnson & Johnson, AstraZeneca, sanofi-aventis, Novartis, Esperance Pharmaceuticals, Inc, Boehringer Ingelheim, Vermillion, Inc, Endocyte, Inc, and GlaxoSmithKline.

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Authors and Affiliations

  1. Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Shannon N. Westin & Robert L. Coleman

  2. Division of Gynecologic Oncology, Department of OB/GYN, Columbia University College of Physicians and Surgeons, New York, NY, USA

    Thomas J. Herzog

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  1. Shannon N. Westin
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  2. Thomas J. Herzog
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  3. Robert L. Coleman
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Correspondence to Shannon N. Westin.

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Westin, S.N., Herzog, T.J. & Coleman, R.L. Investigational agents in development for the treatment of ovarian cancer. Invest New Drugs 31, 213–229 (2013). https://doi.org/10.1007/s10637-012-9837-3

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