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Influences of the Gut Microbiota on DNA Methylation and Histone Modification

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Abstract

The gut microbiota is a vast ensemble of microorganisms inhabiting the mammalian gastrointestinal tract that can impact physiologic and pathologic processes. However, our understanding of the underlying mechanism for the dynamic interaction between host and gut microbiota is still in its infancy. The highly evolved epigenetic modifications allow hosts to reprogram the genome in response to environmental stimuli, which may play a key role in triggering multiple human diseases. In spite of increasing studies in gut microbiota and epigenetic modifications, the correlation between them has not been well elaborated. Here, we review current knowledge of gut microbiota impacts on epigenetic modifications, the major evidence of which centers on DNA methylation and histone modification of the immune system.

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Acknowledgments

We thank Haiyang Hu for figure preparation. This study was supported by the Key Program of the National Natural Science Foundation of China (No. 81330011) and the National Basic Research Program of China (973 Program) (No. 2013CB531401).

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Authors and Affiliations

  1. State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China

    Jianzhong Ye, Wenrui Wu, Yating Li & Lanjuan Li

  2. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, China

    Jianzhong Ye, Wenrui Wu, Yating Li & Lanjuan Li

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  1. Jianzhong Ye
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  2. Wenrui Wu
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  3. Yating Li
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  4. Lanjuan Li
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Correspondence to Lanjuan Li.

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Ye, J., Wu, W., Li, Y. et al. Influences of the Gut Microbiota on DNA Methylation and Histone Modification. Dig Dis Sci 62, 1155–1164 (2017). https://doi.org/10.1007/s10620-017-4538-6

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  • DOI: https://doi.org/10.1007/s10620-017-4538-6

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