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Synthesis of 12-amino-11-dihomodrimane Sesquiterpenoids from Norambreinolide

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Chemistry of Natural Compounds Aims and scope

A series of dihomodrimane sesquiterpenoids containing an NH2 group were synthesized. 11-Dihomodriman-8α-ol-12-one and its dehydration products, ketones with double bonds in the C7-C8 and C8-C9 positions, were prepared from commercially available norambreinolide. The oximes of the ketones were reduced by LiAlH4 to the corresponding amines.

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Authors and Affiliations

  1. Institute of Chemistry, Academy of Sciences of the Republic of Moldova, Republic of Moldova, MD-2028, Kishinev, Ul. Akademiei, 3

    K. I. Kuchkova, A. N. Aricu, A. N. Barba, E. S. Sekara, P. F. Vlad & N. D. Ungur

Authors
  1. K. I. Kuchkova
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  2. A. N. Aricu
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  3. A. N. Barba
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  4. E. S. Sekara
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  5. P. F. Vlad
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  6. N. D. Ungur
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Corresponding author

Correspondence to A. N. Aricu.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2014, pp. 396–399.

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Kuchkova, K.I., Aricu, A.N., Barba, A.N. et al. Synthesis of 12-amino-11-dihomodrimane Sesquiterpenoids from Norambreinolide. Chem Nat Compd 50, 458–461 (2014). https://doi.org/10.1007/s10600-014-0986-9

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  • DOI: https://doi.org/10.1007/s10600-014-0986-9

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