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Alzheimer’s Disease—A Dysfunction in Cholesterol and Lipid Metabolism

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Abstract

1. Strong etiological association exists between dysfunctional metabolism of brain lipids, age-related changes in the cerebral vasculature and neurodegenerative features characteristic of Alzheimer’s disease (AD) brain.

2. In this short review, recent experimental evidence for these associations is further discussed below.

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Authors and Affiliations

  1. LSU Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8D, New Orleans, Louisiana, 70112-2272

    Walter J. Lukiw, Miguel Pappolla & Nicolas G. Bazan

  2. Department of Opthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, 70112

    Walter J. Lukiw & Nicolas G. Bazan

  3. Department of Neurology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, 70122

    Miguel Pappolla

  4. Diater Pharmaceuticals, Madrid, 28006, Spain

    Ricardo Palacios Pelaez

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  1. Walter J. Lukiw
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  2. Miguel Pappolla
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  3. Ricardo Palacios Pelaez
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  4. Nicolas G. Bazan
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Correspondence to Walter J. Lukiw.

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Lukiw, W.J., Pappolla, M., Pelaez, R.P. et al. Alzheimer’s Disease—A Dysfunction in Cholesterol and Lipid Metabolism. Cell Mol Neurobiol 25, 475–483 (2005). https://doi.org/10.1007/s10571-005-4010-6

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  • DOI: https://doi.org/10.1007/s10571-005-4010-6

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