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Deep Eutectic Solvent as a Recyclable Catalyst for Three-Component Synthesis of β-Amino Carbonyls

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Abstract

We have reported one-pot, three-component Mannich type reaction of aldehyde, amines and ketone (acetone and acetophenones), catalyzed by deep eutectic solvent (choline chloride/zinc chloride) at room temperature to give β-amino carbonyls in good yields. The catalyst could be recycled at least four times without remarkable decrease in its catalytic activity. The general method is easy, fast and environmental friendly.

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Acknowledgments

We are grateful to Professor Akbar Heydari (Tarbiat Modarres University, Tehran, Iran) for his valuable assistance. This work was supported by the research affairs of Isfahan University of Technology.

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Authors and Affiliations

  1. Department of Chemistry, Isfahan University of Technology, 84156-83111, Isfahan, Iran

    Fariba Keshavarzipour & Hossein Tavakol

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  1. Fariba Keshavarzipour
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  2. Hossein Tavakol
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Correspondence to Hossein Tavakol.

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Keshavarzipour, F., Tavakol, H. Deep Eutectic Solvent as a Recyclable Catalyst for Three-Component Synthesis of β-Amino Carbonyls. Catal Lett 145, 1062–1066 (2015). https://doi.org/10.1007/s10562-014-1471-6

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  • DOI: https://doi.org/10.1007/s10562-014-1471-6

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