Abstract
The goal of this review article is to redefine what the mismatch negativity (MMN) component of event-related potentials reflects in auditory scene analysis, and to provide an overview of how the MMN serves as a valuable tool in Cognitive Neuroscience research. In doing so, some of the old beliefs (five common ‘myths’) about MMN will be dispelled, such as the notion that MMN is a simple feature discriminator and that attention itself modulates MMN elicitation. A revised description of what MMN truly reflects will be provided, which includes a principal focus onto the highly context-dependent nature of MMN elicitation and new terminology to discuss MMN and attention. This revised framework will help clarify what has been a long line of seemingly contradictory results from studies in which behavioral ability to hear differences between sounds and passive elicitation of MMN have been inconsistent. Understanding what MMN is will also benefit clinical research efforts by providing a new picture of how to design appropriate paradigms suited to various clinical populations.
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References
Aaltonen O, Niemi P, Nyrke T, Tuhkanen M (1987) Event-related brain potentials and the perception of a phonetic continuum. Biol Psychol 24(3):197–207
Aaltonen O, Tuomainen J, Laine M, Niemi P (1993) Cortical differences in tonal versus vowel processing as revealed by an ERP component called mismatch negativity (MMN). Brain Lang 44(2):139–152
Alho K, Huotilainen M, Tiitinen H, Ilmoniemi RJ, Knuutila J, Näätänen R (1993) Memory-related processing of complex sound patterns in human auditory cortex: a MEG study. NeuroReport 4(4):391–394
Atienza M, Cantero JL, Grau C, Gomez C, Dominguez-Marin E, Escera C (2003) Effects of temporal encoding on auditory object formation: a mismatch negativity study. Brain Res Cogn Brain Res 16(3):359–371
Bendixen A, Jones SJ, Klump G, Winkler I (2010) Probability dependence and functional separation of the object-related and mismatch negativity event-related potential components. Neuroimage 50(1):285–290
Bishop DV, Hardiman MJ (2010) Measurement of mismatch negativity in individuals: a study using single-trial analysis. 47(4):697–705
Bonte ML, Mitterer H, Zellagui N, Poelmans H, Blomert L (2005) Auditory cortical tuning to statistical regularities in phonology. Clin Neurophysiol 116(12):2765–2774
Broadbent DE (1958) Perception and communication. Pergamon Press Ltd, London
Brunellière A, Dufour S, Nguyen N (2011) Regional differences in the listener’s phonemic inventory affect semantic processing: a mismatch negativity (MMN) study. Brain Lang 117(1):45–51
Chen S, Sussman ES (2013) Context effects on auditory distraction. Biol Psychol 94(2):297–309
Colin C, Radeau M, Soquet A, Demolin D, Colin F, Deltenre P (2002) Mismatch negativity evoked by the McGurk-MacDonald effect: a phonetic representation within short-term memory. Clin Neurophysiol 113(4):495–506
Cornell SA, Lahiri A, Eulitz C (2011) “What you encode is not necessarily what you store”: evidence for sparse feature representations from mismatch negativity. Brain Res 1394:79–89
Czigler I (2014) Visual mismatch negativity and categorization. Brain Topogr, in press
Dalebout SD, Stack JW (1999) Mismatch negativity to acoustic differences not differentiated behaviorally. J Am Acad Audiol 10(7):388–399
Davids N, van den Brink D, van Turennout M, Mitterer H, Verhoeven L (2009) Towards neurophysiological assessment of phonemic discrimination: context effects of the mismatch negativity. Clin Neurophysiol 120(6):1078–1086
Deguchi C, Chobert J, Brunellière A, Nguyen N, Colombo L, Besson M (2010) Pre-attentive and attentive processing of French vowels. Brain Res 1366:149–161
Dehaene-Lambertz G, Dupoux E, Gout A (2000) Electrophysiological correlates of phonological processing: a cross-linguistic study. J Cogn Neurosci 12(4):635–647
DeSanctis P, Ritter W, Molholm S, Kelly SP, Foxe JJ (2008) Auditory scene analysis: the interaction of stimulation rate and frequency separation on pre-attentive grou**. Eur J Neurosci 27(5):127–1276
Deutsch JA, Deutsch D (1963) Attention: some theoretical considerations. Psychol Rev 70:80–90
Díaz B, Baus C, Escera C, Costa A, Sebastián-Gallés N (2008) Brain potentials to native phoneme discrimination reveal the origin of individual differences in learning the sounds of a second language. Proc Natl Acad Sci USA 105(42):16083–16088
Dyson BJ, Alain C, He Y (2005) Effects of visual attentional load on low-level auditory scene analysis. Cogn Affect Behav Neurosci 5(3):319–338
Froyen D, Van Atteveldt N, Bonte M, Blomert L (2008) Cross-modal enhancement of the MMN to speech-sounds indicates early and automatic integration of letters and speech-sounds. Neurosci Lett 430(1):23–28
Gao S, Hu J, Gong D, Chen S, Kendrick KM, Yao D (2012) Integration of consonant and pitch processing as revealed by the absence of additivity in mismatch negativity. PLoS ONE 7(5):e38289
Gomes H, Berstein R, Ritter W, Vaughan HG Jr, Miller J (1997) Storage of feature conjunctions in transient auditory memory. Psychophysiology 34(6):712–716
Gomes H, Molholm S, Ritter W, Kurtzberg D, Cowan N, Vaughan HG Jr (2000) Mismatch negativity in children and adults, and effects of an attended task. Psychophysiology 37(6):807–816
Grimm S, Widmann A, Schröger E (2004) Differential processing of duration changes within short and long sounds in humans. Neurosci Lett 356(2):83–86
Hasting AS, Winkler I, Kotz SA (2008) Early differential processing of verbs and nouns in the human brain as indexed by event-related brain potentials. Eur J Neurosci 27(6):1561–1565
Hillyard SA, Hink RF, Schwent VL, Picton TW (1973) Electrical signs of selective attention in the human brain. Science 182(4108):177–180
Hisagi M, Shafer VL, Strange W, Sussman ES (2010) Perception of a Japanese vowel length contrast by Japanese and American English listeners: behavioral and electrophysiological measures. Brain Res 1360:89–105
Hung J, Jones SJ, VazPato M (2001) Scalp potentials to pitch change in rapid tone sequences. A correlate of sequential stream segregation. Exp Brain Res 140(1):56–65
Jacobsen T, Schröger E (2004) Input to verbal working memory: reattentive construction of the central speech representation. Exp Psychol 51(4):231–239
Jakoby H, Goldstein A, Faust M (2011) Electrophysiological correlates of speech perception mechanisms and individual differences in second language attainment. Psychophysiology 48(11):1517–1531
Javitt DC, Grochowski S, Shelley AM, Ritter W (1998) Impaired mismatch negativity (MMN) generation in schizophrenia as a function of stimulus deviance, probability, and interstimulus/interdeviant interval. Electroencephalogr Clin Neurophysiol 108(2):143–153
Koelsch S, Gunter TC, Wittfoth M, Sammler D (2005) Interaction between syntax processing in language and in music: an ERP Study. J Cogn Neurosci 17(10):1565–1577
Kraus N, McGee T, Carrell TD, Sharma A (1995) Neurophysiologic bases of speech discrimination. Ear Hear 16(1):19–37
Kraus N, McGee TJ, Carrell TD, Zecker SG, Nicol TG, Koch DB (1996) Auditory neurophysiologic responses and discrimination deficits in children with learning problems. Science 273:971–973
Kujala T, Näätänen R (2001) The mismatch negativity in evaluating central auditory dysfunction in dyslexia. Neurosci Biobehav Rev 25:535–543
Kujala T, Halmetoja J, Näätänen R, Alku P, Lyytinen H, Sussman E (2006) Speech- and sound-segmentation in dyslexia: evidence for a multiple-level cortical impairment. Eur J Neurosci 24(8):2420–2427
Lee CY, Yen HL, Yeh PW, Lin WH, Cheng YY, Tzeng YL, Wu HC (2012) Mismatch responses to lexical tone, initial consonant, and vowel in Mandarin-speaking preschoolers. Neuropsychologia 50(14):3228–3239
Lepistö T, Kuitunen A, Sussman E, Saalasti S, Jansson-Verkasalo E, Nieminen-von Wendt T, Kujala T (2009) Auditory stream segregation in children with Asperger syndrome. Biol Psychol 82(3):301–307
Lipski SC, Escudero P, Benders T (2012) Language experience modulates weighting of acoustic cues for vowel perception: an event-related potential study. Psychophysiology 49(5):638–650
List A, Justus T, Robertson LC, Bentin S (2007) A mismatch negativity study of local-global auditory processing. Brain Res 1153:122–133
Maiste AC, Wiens AS, Hunt MJ, Scherg M, Picton TW (1995) Event-related potentials and the categorical perception of speech sounds. Ear Hear 16(1):68–90
May PJ, Tiitinen H (2010) Mismatch negativity (MMN), the deviance-elicited auditory deflection, explained. Psychophysiology 47(1):66–122
Miglietta S, Grimaldi M, Calabrese A (2013) Conditioned allophony in speech perception: an ERP study. Brain Lang 126(3):285–290
Morlet D, Fischer C (2014) MMN and novelty P3 in coma and other altered states of consciousness: a review. Brain Topogr, in press
Müller D, Schröger E (2007) Temporal grou** affects the automatic processing of deviant sounds. Biol Psychol 74(3):358–364
Müller D, Widmann A, Schröger E (2005) Auditory streaming affects the processing of successive deviant and standard sounds. Psychophysiology 42:668–676
Näätänen R (1991) Mismatch negativity outside strong attentional focus: a commentary on Woldorff et al. (1991). Psychophysiology 28(4):478–484
Näätänen R (1992) Attention and brain function. Erlbaum, Hillsdale
Näätänen R (2003) Mismatch negativity: clinical research and possible applications. Int J Psychophysiol 48:179–188
Näätänen R, Gaillard AWK, Mäntysalo S (1978) Early selective-attention effect on evoked potential reinterpreted. Acta Psychol 42:313–329
Näätänen R, Paavilainen P, Tiitinen H, Jiang D, Alho K (1993) Attention and mismatch negativity. Psychophysiology 30(5):436–450
Nager W, Teder-Sälejärvi W, Kunze S, Münte TF (2003) Preattentive evaluation of multiple perceptual streams in human audition. NeuroReport 14(6):871–874
Neisser U (1967) Cognitive psychology. Appleton-Century-Crofts, New York
Nenonen S, Shestakova A, Huotilainen M, Näätänen R (2005) Speech-sound duration processing in a second language is specific to phonetic categories. Brain Lang 92(1):26–32
Novak GP, Ritter W, Vaughan HG Jr, Wiznitzer ML (1990) Differentiation of negative event-related potentials in an auditory discrimination task. Electroencephalogr Clin Neurophysiol 75(4):255–275
Novak G, Ritter W, Vaughan HG Jr (1992) Mismatch detection and the latency of temporal judgments. Psychophysiology 29(4):398–411
Paavilainen P, Tiitinen H, Alho K, Näätänen R (1993) Mismatch negativity to slight pitch changes outside strong attentional focus. Biol Psychol 37(1):23–41
Paavilainen P, Jaramillo M, Näätänen R, Winkler I (1999) Neuronal populations in the human brain extracting invariant relationships from acoustic variance. Neurosci Lett 265(3):179–182
Partanen E, Vainio M, Kujala T, Huotilainen M (2011) Linguistic multifeature MMN paradigm for extensive recording of auditory discrimination profiles. Psychophysiology 48(10):1372–1380
Peltola MS, Tamminen H, Toivonen H, Kujala T, Näätänen R (2012) Different kinds of bilinguals: different kinds of brains: the neural organization of two languages in one brain. Brain Lang 121(3):261–266
Perez VB, Woods SW, Roach BJ, Ford JM, McGlashan TH, Srihari VH, Mathalon DH (2013). Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity. Biol Psychiatry, in press
Pulvermüller F, Shtyrov Y (2006) Language outside the focus of attention: the mismatch negativity as a tool for studying higher cognitive processes. Prog Neurobiol 79(1):49–71
Pulvermüller F, Shtyrov Y, Kujala T, Näätänen R (2004) Word-specific cortical activity as revealed by the mismatch negativity. Psychophysiology 41(1):106–112
Rahne T, Böckmann-Barthel M (2009) Visual cues release the temporal coherence of auditory objects in auditory scene analysis. Brain Res 1300:125–134
Rahne T, Sussman E (2009) Neural representations of auditory input accommodate to the context in a dynamically changing acoustic environment. Eur J Neurosci 29(1):205–211
Rahne T, Böckmann M, von Specht H, Sussman E (2007) Visual cues can modulate integration and segregation of objects in auditory scene analysis. Brain Res 1144:127–135
Reiche M, Hartwigsen G, Widmann A, Saur D, Schröger E, Bendixen A (2013) Involuntary attentional capture by speech and non-speech deviations: a combined behavioral-event-related potential study. Brain Res 1490:153–160
Ritter W, Sussman E, Molholm S (2000) Evidence that the mismatch negativity system works on the basis of objects. NeuroReport 11(1):61–63
Saarinen J, Paavilainen P, Schöger E, Tervaniemi M, Näätänen R (1992) Representation of abstract attributes of auditory stimuli in the human brain. NeuroReport 3(12):1149–1451
Sams M, Alho K, Näätänen R (1983) Sequential effects on the ERP in discriminating two stimuli. Biol Psychol 17(1):41–58
Sams M, Paavilainen P, Alho K, Näätänen R (1985) Auditory frequency discrimination and event-related potentials. Electroencephalogr Clin Neurophysiol 62(6):437–448
Savela J, Kujala T, Tuomainen J, Ek M, Aaltonen O, Näätänen R (2003) The mismatch negativity and reaction time as indices of the perceptual distance between the corresponding vowels of two related languages. Brain Res Cogn Brain Res 16(2):250–256
Schöger E (1995) Processing of auditory deviants with changes in one versus two stimulus dimensions. Psychophysiology 32(1):55–65
Schöger E (1996) The influence of stimulus intensity and inter-stimulus interval on the detection of pitch and loudness changes. Electroencephalogr Clin Neurophysiol 100(6):517–526
Schöger E, Näätänen R, Paavilainen P (1992) Event-related potentials reveal how non-attended complex sound patterns are represented by the human brain. Neurosci Lett 146(2):183–186
Schöger E, Paavilainen P, Näätänen R (1994) Mismatch negativity to changes in a continuous tone with regularly varying frequencies. Electroencephalogr Clin Neurophysiol 92(2):140–147
Shafer VL, Schwartz RG, Kurtzberg D (2004) Language-specific memory traces of consonants in the brain. Brain Res Cogn Brain Res 18(3):242–254
Sharma A, Dorman MF (1998) Exploration of the perceptual magnet effect using the mismatch negativity auditory evoked potential. J Acoust Soc Am 104(1):511–517
Sharma A, Kraus N, McGee T, Carrell T, Nicol T (1993) Acoustic versus phonetic representation of speech as reflected by the mismatch negativity event-related potential. Electroencephalogr Clin Neurophysiol 88(1):64–71
Shtyrov Y, Pulvermüller F (2002) Neurophysiological evidence of memory traces for words in the human brain. NeuroReport 13(4):521–525
Sokolov EN (1963) Higher nervous functions: the orienting reflex. Annu Rev Phsyiol 25:545–580
Sonnadara RR, Alain C, Trainor LJ (2006) Effects of spatial separation and stimulus probability on the event-related potentials elicited by occasional changes in sound location. Brain Res 1071(1):175–185
Sorokin A, Alku P, Kujala T (2010) Change and novelty detection in speech and non-speech sound streams. Brain Res 23(1327):77–90
Squires KC, Squires NK, Hillyard SA (1975) Vertex evoked potentials in a rating scale detection task: relation to signal probability. Behav Biol 13:21–34
Steinberg J, Truckenbrodt H, Jacobsen T (2010) Preattentive phonotactic processing as indexed by the mismatch negativity. J Cogn Neurosci 22(10):2174–2185
Stekelenburg JJ, Vroomen J (2012) Electrophysiological evidence for a multisensory speech-specific mode of perception. Neuropsychologia 50(7):1425–1431
Sussman E (2005) Integration and segregation in auditory scene analysis. J Acoust Soc Am 117(3):1285–1298
Sussman E (2007) A new view on the MMN and attention debate: auditory context effects. J Psychophysiol 21(3–4):164–175
Sussman E (2013) Attention matters: pitch vs. pattern processing in adolescence. Front Psychol 4(333):1–9
Sussman E, Gumenyuk V (2005) Organization of sequential sounds in auditory memory. NeuroReport 16(13):1519–1523
Sussman E, Steinschneider M (2006) Neurophysiological evidence for context-dependent encoding of sensory input in human auditory cortex. Brain Res 1075(1):165–174
Sussman E, Steinschneider M (2009) Attention effects on auditory scene analysis in children. Neuropsychologia 47(3):771–785
Sussman E, Winkler I (2001) Dynamic sensory updating in the auditory system. Cogn Brain Res 12:431–439
Sussman E, Ritter W, Vaughan HG Jr (1998a) Attention affects the organization of auditory input associated with the mismatch negativity system. Brain Res 789:130–138
Sussman E, Ritter W, Vaughan HG Jr (1998b) Predictability of stimulus deviance and the mismatch negativity. NeuroReport 9(18):4167–4170
Sussman E, Ritter W, Vaughan HG Jr (1999) An investigation of the auditory streaming effect using event-related brain potentials. Psychophysiology 36:22–34
Sussman E, Winkler I, Huotilainen M, Ritter W, Näätänen R (2002) Top-down effects on the initially stimulus-driven auditory organization. Cogn Brain Res 13:393–405
Sussman E, Sheridan K, Kreuzer J, Winkler I (2003a) Representation of the standard: stimulus context effects on the process generating the mismatch negativity component of event-related brain potentials. Psychophysiology 40(3):465–471
Sussman E, Winkler I, Wang W (2003b) MMN and attention: competition for deviance detection. Psychophysiology 40(3):430–435
Sussman E, Kujala T, Halmetoja J, Lyytinen H, Alku P, Näätänen R (2004) Automatic and controlled processing of acoustic and phonetic contrasts. Hear Res 190(1–2):128–140
Sussman E, Bregman AS, Wang WJ, Khan FJ (2005) Attentional modulation of electrophysiological activity in auditory cortex for unattended sounds in multistream auditory environments. Cogn Affect Behav Neurosci 5(1):93–110
Sussman ES, Horváth J, Winkler I, Orr M (2007) The role of attention in the formation of auditory streams. Percept Psychophys 69(1):136–152
Sutton S, Braren M, Zubin J, John ER (1965) Evoked-potential correlates of stimulus uncertainty. Science 150(3700):1187–1188
Szymanski MD, Yund EW, Woods DL (1999) Phonemes, intensity and attention: differential effects on the mismatch negativity (MMN). J Acoust Soc Am 106(6):3492–3505
Tervaniemi M, Kruck S, DeBaene W, Schröger E, Alter K, Friederici AD (2009) Top-down modulation of auditory processing: effects of sound context, musical expertise and attentional focus. Eur J Neurosci 30(8):1636–1642
Tiitinen H, May P, Reinikainen K, Näätänen R (1994) Attentive novelty detection in humans is governed by pre-attentive sensory memory. Nature 372(6501):90–92
Treisman AM (1969) Strategies and models of selective attention. Psychol Rev 76:282–299
van Linden S, Stekelenburg JJ, Tuomainen J, Vroomen J (2007) Lexical effects on auditory speech perception: an electrophysiological study. Neurosci Lett 420(1):49–52
van Zuijen TL, Sussman E, Winkler I, Näätänen R, Tervaniemi M (2004) Grou** of sequential sounds—an event-related potential study comparing musicians and nonmusicians. J Cogn Neurosci 16(2):331–338
Wang XD, Gu F, He K, Chen LH, Chen L (2012) Preattentive extraction of abstract auditory rules in speech sound stream: a mismatch negativity study using lexical tones. PLoS ONE 7(1):e30027
Wei JH, Chan TC, Luo YJ (2002) A modified oddball paradigm “cross-modal delayed response” and the research on mismatch negativity. Brain Res Bull 57(2):221–230
Winkler I, Lehtokoski A, Alku P, Vainio M, Czigler I, Csépe V, Aaltonen O, Raimo I, Alho K, Lang H, Iivonen A, Näätänen R (1999) Pre-attentive detection of vowel contrasts utilizes both phonetic and auditory memory representations. Brain Res Cogn Brain Res 7(3):357–369
Winkler I, Korzyukov O, Gumenyuk V, Cowan N, Linkenkaer-Hansen K, Ilmoniemi RJ, Alho K, Näätänen R (2002) Temporary and longer term retention of acoustic information. 39(4):530–534
Winkler I, Kujala T, Alku P, Näätänen R (2003a) Language context and phonetic change detection. Brain Res Cogn Brain Res 17(3):833–844
Winkler I, Sussman E, Tervaniemi M, Horváth J, Ritter W, Näätänen R (2003b) Preattentive auditory context effects. Cogn Affect Behav Neurosci 3(1):57–77
Winkler I, Takegata R, Sussman E (2005) Event-related brain potentials reveal multiple stages in the perceptual organization of sound. Brain Res Cogn Brain Res 25(1):291–299
Woldorff MG, Hackley SA, Hillyard SA (1991) The effects of channel-selective attention on the mismatch negativity wave elicited by deviant tones. Psychophysiology 28(1):30–42
Woldorff MG, Hillyard SA, Gallen CC, Hampson SR, Bloom FE (1998) Magnetoencephalographic recordings demonstrate attentional modulation of mismatch-related neural activity in human auditory cortex. Psychophysiology 35(3):283–292
** J, Zhang L, Shu H, Zhang Y, Li P (2010) Categorical perception of lexical tones in Chinese revealed by mismatch negativity. Neuroscience 170(1):223–231
Yabe H, Winkler I, Czigler I, Koyama S, Kakigi R, Sutoh T, Hiruma T, Kaneko S (2001) Organizing sound sequences in the human brain: the interplay of auditory streaming and temporal integration. Cogn Brain Res 897:222–227
Ylinen S, Uther M, Latvala A, Vepsäläinen S, Iverson P, Akahane-Yamada R, Näätänen R (2010) Training the brain to weight speech cues differently: a study of Finnish second-language users of English. J Cogn Neurosci 22(6):1319–1332
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Support was provided by the National Institute on Deafness and Other Communications Disorders (R01DC004623, E.S.).
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This is one of several papers published together in Brain Topography on the “Special Issue: Mismatch Negativity”.
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Sussman, E.S., Chen, S., Sussman-Fort, J. et al. The Five Myths of MMN: Redefining How to Use MMN in Basic and Clinical Research. Brain Topogr 27, 553–564 (2014). https://doi.org/10.1007/s10548-013-0326-6
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DOI: https://doi.org/10.1007/s10548-013-0326-6