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Antiphasic 40 Hz Oscillatory Current Stimulation Affects Bistable Motion Perception

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Abstract

When viewing ambiguous stimuli, conscious perception alternates spontaneously between competing interpretations of physically unchanged stimulus information. As one possible neural mechanism underlying the perceptual switches, it has been suggested that neurons dynamically change their pattern of synchronized oscillatory activity in the gamma band (30–80 Hz). In support of this hypothesis, there is correlative evidence from human electroencephalographic (EEG) studies for gamma band modulations during ambiguous perception. To establish a causal role of gamma band oscillations in the current study, we applied transcranial alternating current stimulation (tACS) at 40 Hz over occipital–parietal areas of both hemispheres during the presentation of bistable apparent motion stimuli that can be perceived as moving either horizontally or vertically. In this paradigm, the switch between horizontal and vertical apparent motion is likely to involve a change in interhemispheric functional coupling. We examined gamma tACS effects on the durations of perceived horizontal and vertical motion as well as on interhemispheric EEG coherence and found a decreased proportion of perceived horizontal motion together with an increase of interhemispheric gamma band coherence. In a control experiment using 6 Hz tACS, we did not observe any stimulation effects on behavior or coherence. Furthermore, external stimulation at 40 Hz was only effective when applied with 180° phase difference between hemispheres (anti-phase), as compared to in-phase stimulation with 0° phase difference. These findings suggest that externally desynchronizing gamma oscillations between hemispheres impairs interhemispheric motion integration and in turn biases conscious experience of bistable apparent motion.

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Acknowledgments

The study was supported by the Deutsche Forschungsgemeinschaft (DFG), Grants RA 2357/1-1 (S.R., D.S.), HE 3353/6 (C.S.H.), SFB/TRR 31 (C.S.H.), SFB 936 (A.K.E.) and the EU, Grants FP7-ICT-270212 (A.K.E.), ERC-2010-AdG-269716 (A.K.E.), and by an interim grant from the Presidential Chair’s program budget of Oldenburg University (S.R.). We thank Ksenia Khalaidovski for conducting a pilot experiment for this study.

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Authors and Affiliations

  1. Department of Experimental Psychology, Carl von Ossietzky Universität, Ammerländer Heerstr. 114-118, 26129, Oldenburg, Germany

    Daniel Strüber, Stefan Rach, Sina A. Trautmann-Lengsfeld & Christoph S. Herrmann

  2. Research Center Neurosensory Science, Carl von Ossietzky Universität, 26111, Oldenburg, Germany

    Daniel Strüber, Stefan Rach & Christoph S. Herrmann

  3. Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    Sina A. Trautmann-Lengsfeld & Andreas K. Engel

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  1. Daniel Strüber
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  2. Stefan Rach
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  3. Sina A. Trautmann-Lengsfeld
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  4. Andreas K. Engel
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  5. Christoph S. Herrmann
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Correspondence to Christoph S. Herrmann.

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D. Strüber and S. Rach contributed equally to this study.

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Strüber, D., Rach, S., Trautmann-Lengsfeld, S.A. et al. Antiphasic 40 Hz Oscillatory Current Stimulation Affects Bistable Motion Perception. Brain Topogr 27, 158–171 (2014). https://doi.org/10.1007/s10548-013-0294-x

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