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Stimulation of Human Hair Growth by the Recombinant Human Keratinocyte Growth Factor-2 (KGF-2)

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Abstract

Keratinocyte growth factor-2 (KGF-2) is found in dermal papilla fibroblasts and its receptor, fibroblast growth factor receptor 2 (FGFR2), in the neighboring outer root sheath of keratinocytes. Administration of recombinant human KGF-2 (rhKGF-2) at 10 ng  ml−1 significantly stimulated human hair-follicle cell proliferation in organ culture (26–35%). Thus, rhKGF-2 is a promising therapeutic agent to stimulate human hair growth.

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Authors and Affiliations

  1. Department of Biochemistry, Inha University College of Medicine, Incheon, 400-712, Korea

    Jun-Hyeog Jang

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  1. Jun-Hyeog Jang
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Correspondence to Jun-Hyeog Jang.

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Jang, JH. Stimulation of Human Hair Growth by the Recombinant Human Keratinocyte Growth Factor-2 (KGF-2). Biotechnol Lett 27, 749–752 (2005). https://doi.org/10.1007/s10529-005-5624-y

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  • DOI: https://doi.org/10.1007/s10529-005-5624-y

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