We studied high-resolution 1H nuclear magnetic resonance spectra of the serum and serum albumin from patients with the fi rst episode of schizophrenia and healthy individuals. A relative increase in signal intensities of CH2 protons in serum LDL and VLDL in schizophrenia was demonstrated. Higher intensities of CH2 and CH3 protons of non-esterifi ed fatty acids were found in 1H nuclear magnetic resonance spectra of serum albumin. These data attest to an essential role of changes in lipid metabolism and changed ligand load of albumin in schizophrenia.
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G. E. Dobretsov, Yu. A. Gryzunov, N. V. Smolina, et al., Efferentnaya i Fiz. Khim. Meditsina, No. 1, 16-26 (2009).
T. N. Kolokolova, O. Yu. Savelyev, and N. M. Sergeev, Zh. Analit. Khim., 63, 118-136 (2008).
M. G. Uzbekov, E. Yu. Misionzhik, A. B. Shmukler, et al., Zh. Nevrol. Psikhiatr., 109, 48-52 (2009).
M. Ala-Korpela, Expert Rev. Mol. Diagn., 7, No. 6, 761-773 (2007).
A. Bax, J. Magn. Res., 65, 142-145 (1985).
T. Engan, J. Krane, and S. Kvinnsland, NMR in Biomed., 4, No. 3, 142-149 (1991).
T. L. Huang and J. F. Chen, Schizophr. Res., 80, No. 1, 55-59 (2005).
J. K. Nicholson, P. J. Foxall, M. Spraul, et al., Anal. Chem., 67, No. 5, 793-811 (1995).
T. Oida, J. Biochem., 100, No. 6, 1533-1542 (1986).
M. Omori, T. Murata, H. Kimura, et al., Psychiatry Res., 98, No. 3, 155-162 (2000).
T. T. Tsang, J. J. Huang, E. Holmes, and S. Bahn, J. Proteome Res., 5, No. 4, 756-760 (2006).
T. Tukiainen, T. Tynkkynen, V. P. Makinen, et al., Biochem. Biophys. Res. Commun., 375, No. 3, 356-361 (2008).
A. Vasileva, M. Jakob, and F. Hasko, J. Chromatogr., 216, 279-284 (1981).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 12, pp. 694-697, December, 2011
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Babushkina, T.A., Klimova, T.P., Peregudov, A.S. et al. Study of High-Resolution H1 Nuclear Magnetic Resonance Spectra of the Serum and Its Albumin Fraction in Patients with the First Schizophrenia Episode. Bull Exp Biol Med 152, 748–751 (2012). https://doi.org/10.1007/s10517-012-1622-y
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DOI: https://doi.org/10.1007/s10517-012-1622-y