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Role of potassium and chlorine channels in the regulation of thymocyte volume in rats

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Abstract

Regulatory decrease in thymocyte volume under conditions of osmotic stress was abolished by potassium and chlorine channel blockers. Osmotic stress-activated chlorine channels belong to 2 pharmacological types. The maxi-anion channel is sensitive to Gd3+. The volume-sensitive outwardly rectifying chlorine channel is inhibited with glybenclamide and phloretin.

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Authors and Affiliations

  1. Laboratory of Molecular Physiology, Institute of Physiology and Biophysics, Uzbekistan Academy of Sciences, Tashkent, Uzbekistan

    R. S. Kurbannazarova, B. A. Tashmukhamedov & R. Z. Sabirov

  2. Department of Biophysics, Uzbekistan National University, Tashkent, Uzbekistan

    R. S. Kurbannazarova, B. A. Tashmukhamedov & R. Z. Sabirov

Authors
  1. R. S. Kurbannazarova
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  2. B. A. Tashmukhamedov
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  3. R. Z. Sabirov
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Correspondence to R. Z. Sabirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 5, pp. 544–547, May, 2008

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Kurbannazarova, R.S., Tashmukhamedov, B.A. & Sabirov, R.Z. Role of potassium and chlorine channels in the regulation of thymocyte volume in rats. Bull Exp Biol Med 145, 606–609 (2008). https://doi.org/10.1007/s10517-008-0152-0

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  • DOI: https://doi.org/10.1007/s10517-008-0152-0

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