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Exploring the role of ITGB6: fibrosis, cancer, and other diseases

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Abstract

Integrin β6 (ITGB6), a member of the integrin family of proteins, is only present in epithelial tissues and frequently associates with integrin subunit αv to form transmembrane heterodimers named integrin αvβ6. Importantly, ITGB6 determines αvβ6 expression and availability. In addition to being engaged in organ fibrosis, ITGB6 is also directly linked to the emergence of cancer, periodontitis, and several potential genetic diseases. Therefore, it is of great significance to study the molecular-biological mechanism of ITGB6, which could provide novel insights for future clinical diagnosis and therapy. This review introduces the structure, distribution, and biological function of ITGB6. This review also expounds on ITGB6-related diseases, detailing the known biological effects of ITGB6.

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Figures were partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license.

Abbreviations

ITGB6:

Integrin β6

ITGAV:

Integrin αv

MMP:

Matrix metalloproteinase

TGF-β1:

Transforming growth factor β-1

BDEC:

Bile duct epithelial cells

VSMC:

Vascular smooth muscle cells

Elk1:

ETS domain-containing protein

FAK:

Focal adhesion kinase

EMT:

Epithelial-mesenchymal transformation

FOXO1:

Forkhead box O-1

STAT3:

Signal transducers and transcriptional of activator 3

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Funding

This work was supported by the National Natural Science Foundation of China (82200330, 82270526, and 82070422), China Postdoctoral Science Foundation (2022M722571), Research Plan Project of Shaanxi Institute of Basic Science (22JHQ053), High-end Foreign Expert Introduction Program of National Science and Technology (G2022040014L), Qinchuangyuan Traditional Chinese Medicine Innovation Research and Development Transformation Project (2022-QCYZH-036).

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  1. Zhe Zhang, Zheng Wang and Tong Liu contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiology, Faculty of Life Sciences and Medicine, The Affiliated Hospital of Northwest University, Northwest University, **’an No.3 Hospital, **’an, 710021, China

    Zhe Zhang, Tong Liu, Yanqing Liu, Tiantian Gou, Kangli Chen, Li Wang, Juan Zhang, Yang Yang & Huan Zhang

  2. Key Laboratory of Resource Biology and Biotechnology in Western China, Faulty of Life Sciences and Medicine, Ministry of Education, Northwest University, 229 Taibai North Road, **’an, 710069, China

    Zhe Zhang, Tong Liu, Yanqing Liu, Tiantian Gou, Kangli Chen, Li Wang, Juan Zhang, Yang Yang & Huan Zhang

  3. Department of Cardiothoracic Surgery, Central Theater Command General Hospital of Chinese People’s Liberation Army, 627 Wuluo Road, Wuhan, 430070, China

    Zheng Wang

  4. Department of Cardiovascular Surgery, ****g Hospital, The Fourth Military Medical University, 127 Changle West Road, **’an, 710032, China

    Jiayou Tang

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  1. Zhe Zhang
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Contributions

H.Z. and Y.Y. conceives the concept and designs the outline. Z.Z. and Z.W. drafted manuscript. T.L., J.T., Y.L., and T.G. revised and edited the manuscript. K.C., L.W., and J.Z. contributed to picture design. All authors read and approve the final manuscript.

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Correspondence to Yang Yang or Huan Zhang.

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Zhang, Z., Wang, Z., Liu, T. et al. Exploring the role of ITGB6: fibrosis, cancer, and other diseases. Apoptosis 29, 570–585 (2024). https://doi.org/10.1007/s10495-023-01921-6

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