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Regulation of angiogenesis by microRNAs in cardiovascular diseases

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Abstract

Non-coding RNAs are functional RNA molecules comprising the majority of human transcriptome. Only about 1.5% of the human genome is transcribed into messenger RNAs (mRNA) that are translated into proteins. Among the non-coding RNAs, miRNAs are extensively studied and miR targets in endothelial cells, perivascular cells, and angiogenic signaling are relatively well defined. MicroRNAs not only regulate transcripts in situ but also function as paracrine mediators in affecting angiogenesis at distant sites. Exosomal miRs are implicated in modulating endothelial cell function and angiogenesis. Thus miRs have been shown to affect tissue microenvironment in a multitude of ways. A comprehensive analysis of the role of miRs in modulation of angiogenesis and their impact on cardiovascular diseases is presented in this review.

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Acknowledgements

This work was supported in part by the following grants from the NIH, DA007097, DA034582, and funds from the University of Miami, Sylvester Comprehensive Cancer Center.

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Authors and Affiliations

  1. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA

    Devika Kir

  2. Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA

    Erica Schnettler

  3. Department of Surgery, University of Miami, Miami, FL, USA

    Shrey Modi & Sundaram Ramakrishnan

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  1. Devika Kir
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  2. Erica Schnettler
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  4. Sundaram Ramakrishnan
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Correspondence to Devika Kir.

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Kir, D., Schnettler, E., Modi, S. et al. Regulation of angiogenesis by microRNAs in cardiovascular diseases. Angiogenesis 21, 699–710 (2018). https://doi.org/10.1007/s10456-018-9632-7

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