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Target intraocular pressure for stability of visual field loss progression in normal-tension glaucoma

  • Clinical Investigation
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Abstract

Purpose

To determine the target intraocular pressure (IOP) level in normal-tension glaucoma (NTG) for visual field (VF) stability following trabeculectomy.

Methods

Forty eyes of 40 patients who underwent trabeculectomy were enrolled in this study. Progression was determined by a decrease in the Advanced Glaucoma Intervention Study VF defect score of four or more points. The Kaplan-Meier life table method was employed to compare the postoperative VF stability with predetermined IOP levels.

Results

The mean postoperative follow-up period was 12 years. At the final visit, the IOP was reduced from 15.2 to 9.4 mmHg on average (P < 0.0001). Reductions in IOP of 20% from baseline were achieved in 70.0% of eyes. The cumulative probability of VF stability was 92.7% in patients having an IOP reduction of >20%, whereas all patients in the poorly controlled IOP group showed progression (P < 0.0001). When IOP values of 9, 10, 11, and 12 mmHg were employed as the cutoff, the best VF prognosis was attained in eyes with a postoperative IOP of 10 mmHg.

Conclusions

An IOP reduction of at least 20% from baseline or IOP ≤10 mmHg is recommended as the target postoperative IOP in progressive NTG.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan

    Akira Aoyama, Kyoko Ishida, Akira Sawada & Tetsuya Yamamoto

  2. Department of Ophthalmology, Gifu Prefectural General Medical Center, Gifu, Japan

    Kyoko Ishida

  3. Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan

    Kyoko Ishida

Authors
  1. Akira Aoyama
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  2. Kyoko Ishida
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  3. Akira Sawada
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  4. Tetsuya Yamamoto
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Corresponding author

Correspondence to Kyoko Ishida.

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Aoyama, A., Ishida, K., Sawada, A. et al. Target intraocular pressure for stability of visual field loss progression in normal-tension glaucoma. Jpn J Ophthalmol 54, 117–123 (2010). https://doi.org/10.1007/s10384-009-0779-z

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  • DOI: https://doi.org/10.1007/s10384-009-0779-z

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