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Temperature-Induced Ionic Liquids Dispersive Liquid–Liquid Microextraction of Tetracycline Antibiotics in Environmental Water Samples Assisted by Complexation

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Abstract

In this study, dispersive liquid–liquid microextraction (DLLME) combined with ultra high pressure liquid chromatography (UHPLC)–tunable ultraviolet detection (TUV), was developed for pre-concentration and determination of trace levels of tetracyclines, including 4-epitetracycline, 4-epichlortetracycline, doxycycline, chlortetracycline oxytetracycline, tetracycline, 4-epianhydrotetracycline and anhydrotetracycline, in aqueous samples. La (III) was used as the chelating agent to form a hydrophobic complex compound with tetracyclines, followed by extraction with ionic liquids. Some important parameters that may affect extraction efficiencies were examined and optimized. Under the optimum conditions, linearity of the method was observed in the range of 0.1–200 μg L−1, with correlation coefficients (r 2) >0.992. The limits of detection and quantification were 0.031–0.079 and 0.10–0.26 μg L−1, respectively. The spiked recoveries of eight target compounds in river water, fishpond water and hog leachate were achieved in the range of 62.6–96.3, 58.9–94.5, 55.1–86.1%, respectively.

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Acknowledgments

We gratefully acknowledge the financial support of this work by the National Basic Research Program of China (20877092).

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Inner Mongolia University, No.235, Daxue ** Road, Hohhot, 010021, Inner Mongolia, China

    Dekun Hou, Yan Guan & **aowei Di

  2. Research Center of Eco-Environment Sciences, Chinese Academy of Sciences, Bei**g, 100085, China

    Dekun Hou

Authors
  1. Dekun Hou
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  2. Yan Guan
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  3. **aowei Di
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Correspondence to Dekun Hou or **aowei Di.

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Hou, D., Guan, Y. & Di, X. Temperature-Induced Ionic Liquids Dispersive Liquid–Liquid Microextraction of Tetracycline Antibiotics in Environmental Water Samples Assisted by Complexation. Chromatographia 73, 1057–1064 (2011). https://doi.org/10.1007/s10337-011-1992-8

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