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Electrochemical determinations of 6-mercaptopurine on the surface of a carbon nanotube-paste electrode modified with a cobalt salophen complex

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Abstract

A mixture of multi-walled carbon nanotube/graphite paste electrode modified with a salophen complex of cobalt was prepared and was applied for the study of the electrochemical behavior of 6-mercaptopurine (MP) using cyclic and differential pulse voltammetry (DPV). An excellent electrocatalytic activity toward the oxidation of MP was achieved, which led to a considerable lowering in the anodic overpotential and remarkable increase in the response sensitivity in comparison with unmodified electrode. Utilizing DPV method, a linear dynamic range of 1–100 μM with detection limit of 0.1 μM was obtained in phosphate buffer of pH 3.0. The electrochemical detection system was very stable, and the reproducibility of the electrode response, based on the six measurements during 1 month, was less than 3.0% for the slope of the calibration curves of MP. The electrochemical method as a simple, sensitive, and selective method was developed for the determination of MP in pharmaceutical dosage form and human plasma without any treatments.

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Acknowledgments

The authors gratefully acknowledge the support of this work by the Research Council and the Center of Excellence for Nanostructures of the Sharif University of Technology, Tehran, Iran.

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Authors and Affiliations

  1. Department of Chemistry, Sharif University of Technology, Tehran, 11155-9516, Iran

    Saeed Shahrokhian & Fatemeh Ghorbani-Bidkorbeh

  2. Institute for Nanoscience and Technology, Sharif University of Technology, Tehran, Iran

    Saeed Shahrokhian

  3. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Fatemeh Ghorbani-Bidkorbeh & Rasoul Dinarvand

  4. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Ali Mohammadi

  5. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran

    Rasoul Dinarvand

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  1. Saeed Shahrokhian
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  2. Fatemeh Ghorbani-Bidkorbeh
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  3. Ali Mohammadi
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  4. Rasoul Dinarvand
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Correspondence to Saeed Shahrokhian.

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Shahrokhian, S., Ghorbani-Bidkorbeh, F., Mohammadi, A. et al. Electrochemical determinations of 6-mercaptopurine on the surface of a carbon nanotube-paste electrode modified with a cobalt salophen complex. J Solid State Electrochem 16, 1643–1650 (2012). https://doi.org/10.1007/s10008-011-1575-5

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  • DOI: https://doi.org/10.1007/s10008-011-1575-5

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