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Role of neuronal nitric oxide synthase in the regulation of the neuroendocrine stress response in rodents: insights from mutant mice

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Summary.

Nitric oxide (NO) is a free radical gas synthesised from arginine and oxygen by enzymes of the family of the nitric oxide synthase. In particular, the neuronal nitric oxide synthase (nNOS) is highly expressed by cells of the hypothalamic paraventricular nucleus, where the sympatho-adrenal system, the hypothalamic-pituitary-adrenal axis and the hypothalamic-neurohypophyseal system originate. These structures are deputed to regulate the neuroendocrine stress response. In the past years, evidence has been accumulated to suggest that NO of nNOS origin plays a significant role in modulating the activity of the above mentioned systems under acute stressor exposure. The availability of nNOS knock-out mice allowed to investigate not only the physiological consequences of a constitutive lack of NO of nNOS origin at the hormonal and molecular level, but also to examine possible behavioural alterations. In this review, we shall discuss and confront the current trends of research in this area, especially focusing on the latest findings gained from genetically modified mice.

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References

  • K Abe LH Pan M Watanabe H Konno T Kato Y Itoyama (1997) ArticleTitleUpregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis Neurol Res 19 124–128 Occurrence Handle9175139 Occurrence Handle1:CAS:528:DyaK2sXjtleksb8%3D

    PubMed  CAS  Google Scholar 

  • M Afework A Tomlinson G Burnstock (1994) ArticleTitleDistribution and colocalization of nitric oxide synthase and NADPH-diaphorase in adrenal gland of develo**, adult and aging Sprague-Dawley rats Cell Tissue Res 276 133–141 Occurrence Handle7514499 Occurrence Handle1:CAS:528:DyaK2cXlslGqsLg%3D

    PubMed  CAS  Google Scholar 

  • G Aguilera C Rabadan-Diehl (2000) ArticleTitleVasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptation Regul Pept 96 23–29 Occurrence Handle11102648 Occurrence Handle1:CAS:528:DC%2BD3cXotlCru78%3D

    PubMed  CAS  Google Scholar 

  • WK Alderton CE Cooper RG Knowles (2001) ArticleTitleNitric oxide synthases: structure, function and inhibition Biochem J 357 593–615 Occurrence Handle11463332 Occurrence Handle1:CAS:528:DC%2BD3MXmtFent70%3D

    PubMed  CAS  Google Scholar 

  • L Angelucci (2000) ArticleTitleThe glucocorticoid hormone: from pedestal to dust and back Eur J Pharmacol 405 139–147 Occurrence Handle11033321 Occurrence Handle1:CAS:528:DC%2BD3cXnt1Sit7k%3D

    PubMed  CAS  Google Scholar 

  • FA Antoni (1993) ArticleTitleVasopressinergic control of pituitary adrenocorticotropin secretion comes of age Front Neuroendocrinol 14 76–122 Occurrence Handle8387436 Occurrence Handle1:STN:280:DyaK3s3lt1Wnuw%3D%3D

    PubMed  CAS  Google Scholar 

  • ML Arbones J Ribera L Agullo MA Baltrons A Casanovas V Riveros-Moreno A Garcia (1996) ArticleTitleCharacteristics of nitric oxide synthase type I of rat cerebellar astrocytes Glia 18 224–232 Occurrence Handle8915654 Occurrence Handle1:STN:280:DyaK2s%2Fnt12jsg%3D%3D

    PubMed  CAS  Google Scholar 

  • R Arevalo F Sanchez JR Alonso J Carretero R Vazquez J Aijon (1992) ArticleTitleNADPH-diaphorase activity in the hypothalamic magnocellular neurosecretory nuclei of the rat Brain Res Bull 28 599–603 Occurrence Handle1617442 Occurrence Handle1:CAS:528:DyaK38XktVCksbo%3D

    PubMed  CAS  Google Scholar 

  • K Asano CB Chee B Gaston CM Lilly C Gerard JM Drazen JS Stamler (1994) ArticleTitleConstitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells Proc Natl Acad Sci USA 91 10089–10093 Occurrence Handle7524082 Occurrence Handle1:CAS:528:DyaK2cXmsFansb4%3D

    PubMed  CAS  Google Scholar 

  • T Bandaletova I Brouet H Bartsch T Sugimura H Esumi H Ohshima (1993) ArticleTitleImmunohistochemical localization of an inducible form of nitric oxide synthase in various organs of rats treated with Propionibacterium acnes and lipopolysaccharide Apmis 101 330–336 Occurrence Handle7686760 Occurrence Handle1:CAS:528:DyaK3sXltlKis7Y%3D Occurrence Handle10.1111/j.1699-0463.1993.tb00118.x

    Article  PubMed  CAS  Google Scholar 

  • W Bargmann (1949) ArticleTitleÜber die neurosekretorische Verknüpfung von Hpothalamus und Neurohypophyse Z Zellforsch 34 610–634 Occurrence Handle15391263 Occurrence Handle1:STN:280:DyaG3c%2FgtVyqtw%3D%3D

    PubMed  CAS  Google Scholar 

  • W Bargmann E Scharrer (1951) ArticleTitleThe site of origin of the hormones of the posterior pituitary Am Scie 39 255–259

    Google Scholar 

  • CR Benedict M Fillenz C Stanford (1978) ArticleTitleChanges in plasma noradrenaline concentration as a measure of release rate Br J Pharmacol 64 305–309 Occurrence Handle709000 Occurrence Handle1:CAS:528:DyaE1M**tVWjurs%3D

    PubMed  CAS  Google Scholar 

  • HG Bernstein G Keilhoff B Seidel A Stanarius PL Huang MC Fishman M Reiser B Bogerts G Wolf (1998) ArticleTitleExpression of hypothalamic peptides in mice lacking neuronal nitric oxide synthase: reduced beta-END immunoreactivity in the arcuate nucleus Neuroendocrinology 68 403–411 Occurrence Handle9873204 Occurrence Handle1:CAS:528:DyaK1M**tlOiug%3D%3D

    PubMed  CAS  Google Scholar 

  • G Bhat VB Mahesh K Aguan DW Brann (1996) ArticleTitleEvidence that brain nitric oxide synthase is the major nitric oxide synthase isoform in the hypothalamus of the adult female rat and that nitric oxide potently regulates hypothalamic cGMP levels Neuroendocrinology 64 93–102 Occurrence Handle8857603 Occurrence Handle1:CAS:528:DyaK28Xkslygsro%3D

    PubMed  CAS  Google Scholar 

  • SD Bilbo AK Hotchkiss S Chiavegatto RJ Nelson (2003) ArticleTitleBlunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase J Neuroimmunol 140 41–48 Occurrence Handle12864970 Occurrence Handle1:CAS:528:DC%2BD3sXlsVWqu70%3D

    PubMed  CAS  Google Scholar 

  • SR Bornstein M Ehrhart-Bornstein WA Scherbaum EF Pfeiffer JJ Holst (1990) ArticleTitleEffects of splanchnic nerve stimulation on the adrenal cortex may be mediated by chromaffin cells in a paracrine manner Endocrinology 127 900–906 Occurrence Handle2373060 Occurrence Handle1:CAS:528:DyaK3cXltV2nu7g%3D

    PubMed  CAS  Google Scholar 

  • SR Bornstein M Ehrhart-Bornstein H Usadel M Bockmann WA Scherbaum (1991) ArticleTitleMorphological evidence for a close interaction of chromaffin cells with cortical cells within the adrenal gland Cell Tissue Res 265 1–9 Occurrence Handle1913772 Occurrence Handle1:STN:280:DyaK38%2FgsFKhsQ%3D%3D

    PubMed  CAS  Google Scholar 

  • SR Bornstein JA Gonzalez-Hernandez M Ehrhart-Bornstein G Adler WA Scherbaum (1994) ArticleTitleIntimate contact of chromaffin and cortical cells within the human adrenal gland forms the cellular basis for important intraadrenal interactions J Clin Endocrinol Metab 78 225–232 Occurrence Handle7507122 Occurrence Handle1:STN:280:DyaK2c7hslKiuw%3D%3D

    PubMed  CAS  Google Scholar 

  • DS Bredt (1999) ArticleTitleEndogenous nitric oxide synthesis: biological functions and pathophysiology Free Radic Res 31 577–596 Occurrence Handle10630682 Occurrence Handle1:CAS:528:DyaK1MXnvFygsbo%3D

    PubMed  CAS  Google Scholar 

  • DS Bredt PM Hwang SH Snyder (1990) ArticleTitleLocalization of nitric oxide synthase indicating a neural role for nitric oxide Nature 347 768–770 Occurrence Handle1700301 Occurrence Handle1:CAS:528:DyaK3cXmt1yhu7Y%3D

    PubMed  CAS  Google Scholar 

  • L Brunetti P Preziosi E Ragazzoni M Vacca (1993) ArticleTitleInvolvement of nitric oxide in basal and interleukin-1 beta-induced CRH and ACTH release in vitro Life Sci 53 219–222

    Google Scholar 

  • AB Brussaard KS Kits TA de Vlieger (1996) ArticleTitlePostsynaptic mechanism of depression of GABAergic synapses by oxytocin in the supraoptic nucleus of immature rat J Physiol 497 495–507 Occurrence Handle8961190 Occurrence Handle1:CAS:528:DyaK2sXjtVaq

    PubMed  CAS  Google Scholar 

  • E Butt J Geiger T Jarchau SM Lohmann U Walter (1993) ArticleTitleThe cGMP-dependent protein kinase – gene, protein, and function Neurochem Res 18 27–42 Occurrence Handle8385276 Occurrence Handle1:CAS:528:DyaK3sXnslGqsw%3D%3D

    PubMed  CAS  Google Scholar 

  • G Canteros V Rettori A Franchi A Genaro E Cebral A Faletti M Gimeno SM McCann (1995) ArticleTitleEthanol inhibits luteinizing hormone-releasing hormone (LHRH) secretion by blocking the response of LHRH neuronal terminals to nitric oxide Proc Natl Acad Sci USA 92 3416–3420 Occurrence Handle7724577 Occurrence Handle1:CAS:528:DyaK2MXltFSnu7s%3D

    PubMed  CAS  Google Scholar 

  • GA Carrasco LD Van de Kar (2003) ArticleTitleNeuroendocrine pharmacology of stress Eur J Pharmacol 463 235–272 Occurrence Handle12600714 Occurrence Handle1:CAS:528:DC%2BD3sXhsVamsrk%3D

    PubMed  CAS  Google Scholar 

  • S Ceccatelli L Grandison RE Scott DW Pfaff LM Kow (1996) ArticleTitleEstradiol regulation of nitric oxide synthase mRNAs in rat hypothalamus Neuroendocrinology 64 357–363 Occurrence Handle8930936 Occurrence Handle1:CAS:528:DyaK28XntFSisLk%3D

    PubMed  CAS  Google Scholar 

  • S Ceccatelli AL Hulting X Zhang L Gustafsson M Villar T Hokfelt (1993) ArticleTitleNitric oxide synthase in the rat anterior pituitary gland and the role of nitric oxide in regulation of luteinizing hormone secretion Proc Natl Acad Sci USA 90 11292–11296 Occurrence Handle7504302 Occurrence Handle1:CAS:528:DyaK2cXks1aqtw%3D%3D

    PubMed  CAS  Google Scholar 

  • GP Chrousos PW Gold (1992) ArticleTitleThe concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis J Am Med Assoc 267 1244–1252 Occurrence Handle1:STN:280:DyaK387mslGgtg%3D%3D

    CAS  Google Scholar 

  • M Colasanti T Persichini C Fabrizi E Cavalieri G Venturini P Ascenzi GM Lauro H Suzuki (1998) ArticleTitleExpression of a NOS-III-like protein in human astroglial cell culture Biochem Biophys Res Commun 252 552–555 Occurrence Handle9837744 Occurrence Handle1:CAS:528:DyaK1cXnvF2gsLo%3D

    PubMed  CAS  Google Scholar 

  • B Conte-Devolx C Oliver P Giraud E Castanas F Boudouresque P Gillioz Y Millet (1982) ArticleTitleAdrenocorticotropin, and corticosterone secretion in Brattleboro rats Endocrinology 110 2097–2100 Occurrence Handle6280988 Occurrence Handle1:CAS:528:DyaL38XktFOlur8%3D

    PubMed  CAS  Google Scholar 

  • RJ Cork ML Perrone D Bridges J Wandell CA Scheiner RR Mize (1998) ArticleTitleA web-accessible digital atlas of the distribution of nitric oxide synthase in the mouse brain Prog Brain Res 118 37–50 Occurrence Handle9932433 Occurrence Handle1:CAS:528:DyaK1cXnvFynsLk%3D Occurrence Handle10.1016/S0079-6123(08)63199-4

    Article  PubMed  CAS  Google Scholar 

  • A Costa P Trainer M Besser A Grossman (1993) ArticleTitleNitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro Brain Res 605 187–192 Occurrence Handle8481768 Occurrence Handle1:CAS:528:DyaK3s**tVGmtL0%3D

    PubMed  CAS  Google Scholar 

  • ET Cunningham PE Sawchenko (1991) ArticleTitleReflex control of magnocellular vasopressin and oxytocin secretion Trends Neurosci 14 406–411 Occurrence Handle1720582 Occurrence Handle1:CAS:528:DyaK3MXmt1emsLk%3D

    PubMed  CAS  Google Scholar 

  • I Dijkstra R Binnekade FJ Tilders (1996) ArticleTitleDiurnal variation in resting levels of corticosterone is not mediated by variation in adrenal responsiveness to adrenocorticotropin but involves splanchnic nerve integrity Endocrinology 137 540–547 Occurrence Handle8593800 Occurrence Handle1:CAS:528:DyaK28XntVChsQ%3D%3D

    PubMed  CAS  Google Scholar 

  • D Di Scala-Guenot MT Strosser P Richard (1987) ArticleTitleElectrical stimulations of perifused magnocellular nuclei in vitro elicit Ca2+-dependent, tetrodotoxin-insensitive release of oxytocin and vasopressin Neurosci Lett 76 209–214 Occurrence Handle2438605 Occurrence Handle1:CAS:528:DyaL2sXktFyis78%3D

    PubMed  CAS  Google Scholar 

  • J Dohanics GE Hoffman JG Verbalis (1991) ArticleTitleHyponatremia-induced inhibition of magnocellular neurons causes stressor-selective impairment of stimulated adrenocorticotropin secretion in rats Endocrinology 128 331–340 Occurrence Handle1846102 Occurrence Handle1:CAS:528:DyaK3MXpsFekug%3D%3D

    PubMed  CAS  Google Scholar 

  • RC Drugan S Eren A Hazi J Silva JP Christianson S Kent (2005) ArticleTitleImpact of water temperature and stressor controllability on swim stress-induced changes in body temperature, serum corticosterone, and immobility in rats Pharmacol Biochem Behav 82 397–403 Occurrence Handle16236352 Occurrence Handle1:CAS:528:DC%2BD2MXht1Ors7nO

    PubMed  CAS  Google Scholar 

  • NJ Dun SL Dun SY Wu U Forstermann (1993) ArticleTitleNitric oxide synthase immunoreactivity in rat superior cervical ganglia and adrenal glands Neurosci Lett 158 51–54 Occurrence Handle7694200 Occurrence Handle1:CAS:528:DyaK3sXmsVKnsrc%3D

    PubMed  CAS  Google Scholar 

  • AV Edwards CT Jones (1987) ArticleTitleThe effect of splanchnic nerve stimulation on adrenocortical activity in conscious calves J Physiol 382 385–396 Occurrence Handle3040966 Occurrence Handle1:CAS:528:DyaL2sXhtlWhsQ%3D%3D

    PubMed  CAS  Google Scholar 

  • M Ehrhart-Bornstein SR Bornstein J Gonzalez-Hernandez JJ Holst MR Waterman WA Scherbaum (1995) ArticleTitleSympathoadrenal regulation of adrenocortical steroidogenesis Endocr Res 21 13–24 Occurrence Handle7588375 Occurrence Handle1:CAS:528:DyaK2MXmslanu7s%3D Occurrence Handle10.3109/07435809509030417

    Article  PubMed  CAS  Google Scholar 

  • M Engelmann K Ebner R Landgraf CT Wotjak (2006) ArticleTitleEffects of Morris water maze testing on the neuroendocrine stress response and intrahypothalamic release of vasopressin and oxytocin in the rat Horm Behav 50 496–501 Occurrence Handle16875693 Occurrence Handle1:CAS:528:DC%2BD28XotlWrsr8%3D

    PubMed  CAS  Google Scholar 

  • M Engelmann R Landgraf CT Wotjak (2004) ArticleTitleThe hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: an old concept revisited Front Neuroendocrinol 25 132–149 Occurrence Handle15589266 Occurrence Handle1:CAS:528:DC%2BD2cXhtVKltL%2FP

    PubMed  CAS  Google Scholar 

  • M Engelmann M Ludwig (2004) ArticleTitleThe activity of the hypothalamo-neurohypophysial system in response to acute stressor exposure: neuroendocrine and electrophysiological observations Stress 7 91–96 Occurrence Handle15512852 Occurrence Handle1:CAS:528:DC%2BD2cXntlWgtrk%3D

    PubMed  CAS  Google Scholar 

  • M Engelmann CT Wotjak R Landgraf (1998) ArticleTitleDifferential central and peripheral release of vasopressin and oxytocin in response to swim stress in rats Adv Exp Med Biol 449 175–177 Occurrence Handle10026800 Occurrence Handle1:CAS:528:DC%2BD3c**tVOgtLY%3D

    PubMed  CAS  Google Scholar 

  • PJ French J Bijman M Edixhoven AB Vaandrager BJ Scholte SM Lohmann AC Nairn HR de Jonge (1995) ArticleTitleIsotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP-dependent protein kinase II J Biol Chem 270 26626–26631 Occurrence Handle7592887 Occurrence Handle1:CAS:528:DyaK2MXpt1eit7o%3D

    PubMed  CAS  Google Scholar 

  • M Giordano M Vermeulen AS Trevani G Dran G Andonegui JR Geffner (1996) ArticleTitleNitric oxide synthase inhibitors enhance plasma levels of corticosterone and ACTH Acta Physiol Scand 157 259–264 Occurrence Handle8800367 Occurrence Handle1:CAS:528:DyaK28Xjs1Khs78%3D

    PubMed  CAS  Google Scholar 

  • L Givalois S Li G Pelletier (2002) ArticleTitleCentral nitric oxide regulation of the hypothalamic-pituitary-adrenocortical axis in adult male rats Brain Res Mol Brain Res 102 1–8 Occurrence Handle12191488 Occurrence Handle1:CAS:528:DC%2BD38XksVams78%3D

    PubMed  CAS  Google Scholar 

  • PW Gold H Gwirtsman PC Avgerinos LK Nieman WT Gallucci W Kaye D Jimerson M Ebert R Rittmaster DL Loriaux et al. (1986) ArticleTitleAbnormal hypothalamic-pituitary-adrenal function in anorexia nervosa. Pathophysiologic mechanisms in underweight and weight-corrected patients N Engl J Med 314 1335–1342 Occurrence Handle3010109 Occurrence Handle1:STN:280:DyaL283gtlCktQ%3D%3D Occurrence Handle10.1056/NEJM198605223142102

    Article  PubMed  CAS  Google Scholar 

  • K Hashimoto T Nishioka C Tojo T Takao (1995) ArticleTitleNitric oxide plays no role in ACTH release induced by interleukin-1 beta, corticotropin-releasing hormone, arginine vasopressin and phorbol myristate acetate in rat pituitary cell cultures Endocr J 42 435–439 Occurrence Handle7545507 Occurrence Handle1:CAS:528:DyaK28XhtlyktL0%3D

    PubMed  CAS  Google Scholar 

  • S Hatakeyama Y Kawai T Ueyama E Senba (1996) ArticleTitleNitric oxide synthase-containing magnocellular neurons of the rat hypothalamus synthesize oxytocin and vasopressin and express Fos following stress stimuli J Chem Neuroanat 11 243–256 Occurrence Handle8951594 Occurrence Handle1:CAS:528:DyaK2s**vFagsA%3D%3D

    PubMed  CAS  Google Scholar 

  • T Hattori M Morris N Alexander DK Sundberg (1990) ArticleTitleExtracellular oxytocin in the paraventricular nucleus: hyperosmotic stimulation by in vivo microdialysis Brain Res 506 169–171 Occurrence Handle2105821 Occurrence Handle1:CAS:528:DyaK3cXntVCmsA%3D%3D

    PubMed  CAS  Google Scholar 

  • T Hattori DK Sundberg M Morris (1992) ArticleTitleCentral and systemic oxytocin release: a study of the paraventricular nucleus by in vivo microdialysis Brain Res Bull 28 257–263 Occurrence Handle1596746 Occurrence Handle1:CAS:528:DyaK38XhsVChu7s%3D

    PubMed  CAS  Google Scholar 

  • MH Helfrich DE Evans PS Grabowski JS Pollock H Ohshima SH Ralston (1997) ArticleTitleExpression of nitric oxide synthase isoforms in bone and bone cell cultures J Bone Miner Res 12 1108–1115 Occurrence Handle9200011 Occurrence Handle1:CAS:528:DyaK2sXks1CjtrY%3D

    PubMed  CAS  Google Scholar 

  • ML Hermes JM Ruijter A Klop RM Buijs LP Renaud (2000) ArticleTitleVasopressin increases GABAergic inhibition of rat hypothalamic paraventricular nucleus neurons in vitro J Neurophysiol 83 705–711 Occurrence Handle10669486 Occurrence Handle1:CAS:528:DC%2BD3cXhsVSisr4%3D

    PubMed  CAS  Google Scholar 

  • C Heym M Colombo-Benckmann B Mayer (1994) ArticleTitleImmunohistochemical demonstration of the synthesis enzyme for nitric oxide and of comediators in neurons and chromaffin cells of the human adrenal medulla Ann Anat 176 11–16 Occurrence Handle7508210 Occurrence Handle1:STN:280:DyaK2c7js1Oksw%3D%3D

    PubMed  CAS  Google Scholar 

  • M Hirasawa D Mouginot MG Kozoriz SB Kombian QJ Pittman (2003) ArticleTitleVasopressin differentially modulates non-NMDA receptors in vasopressin and oxytocin neurons in the supraoptic nucleus J Neurosci 23 4270–4277 Occurrence Handle12764115 Occurrence Handle1:CAS:528:DC%2BD3sXktFKnsrw%3D

    PubMed  CAS  Google Scholar 

  • MC Holmes FA Antoni G Aguilera KJ Catt (1986) ArticleTitleMagnocellular axons in passage through the median eminence release vasopressin Nature 319 326–329 Occurrence Handle3001538 Occurrence Handle1:CAS:528:DyaL28XhtVarsrc%3D

    PubMed  CAS  Google Scholar 

  • F Holsboer (1999) ArticleTitleThe rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety J Psychiatr Res 33 181–214 Occurrence Handle10367986 Occurrence Handle1:STN:280:DyaK1M3psVCmsA%3D%3D

    PubMed  CAS  Google Scholar 

  • PL Huang TM Dawson DS Bredt SH Snyder MC Fishman (1993) ArticleTitleTargeted disruption of the neuronal nitric oxide synthase gene Cell 75 1273–1286 Occurrence Handle7505721 Occurrence Handle1:CAS:528:DyaK2cXntVOqsw%3D%3D

    PubMed  CAS  Google Scholar 

  • LJ Ignarro (1991) ArticleTitleSignal transduction mechanisms involving nitric oxide Biochem Pharmacol 41 485–490 Occurrence Handle1847633 Occurrence Handle1:CAS:528:DyaK3MXhs1Wlsrk%3D

    PubMed  CAS  Google Scholar 

  • Itoh S, Yamada S, Mori T, Miwa T, Tottori K, Uwahodo Y, Yamamura Y, Fukuda M, Yamamoto K, Tanoue A, Tsujimoto G (2006) Attenuated stress-induced catecholamine release in mice lacking the vasopressin V1b receptor. Am J Physiol Endocrinol Metab (in press)

  • DM Kaye SD Wiviott L Kobzik RA Kelly TW Smith (1997) ArticleTitleS-nitrosothiols inhibit neuronal norepinephrine transport Am J Physiol 272 875–883

    Google Scholar 

  • WH Kaye HE Gwirtsman DT George MH Ebert DC Jimerson TP Tomai GP Chrousos PW Gold (1987) ArticleTitleElevated cerebrospinal fluid levels of immunoreactive corticotropin-releasing hormone in anorexia nervosa: relation to state of nutrition, adrenal function, and intensity of depression J Clin Endocrinol Metab 64 203–208 Occurrence Handle3491830 Occurrence Handle1:STN:280:DyaL2s%2FotlOluw%3D%3D

    PubMed  CAS  Google Scholar 

  • CK Kim CL Rivier (2000) ArticleTitleNitric oxide and carbon monoxide have a stimulatory role in the hypothalamic-pituitary-adrenal response to physico-emotional stressors in rats Endocrinology 141 2244–2253 Occurrence Handle10830314 Occurrence Handle1:CAS:528:DC%2BD3cXlt1WmsLc%3D

    PubMed  CAS  Google Scholar 

  • D Kim HJ Choi SW Kim SW Cho O Hwang (2003) ArticleTitleUpregulation of catecholamine biosynthetic enzymes by nitric oxide J Neurosci Res 72 98–104 Occurrence Handle12645083 Occurrence Handle1:CAS:528:DC%2BD3s**vFClsLs%3D

    PubMed  CAS  Google Scholar 

  • JP Kiss ES Vizi (2001) ArticleTitleNitric oxide: a novel link between synaptic and nonsynaptic transmission Trends Neurosci 24 211–215 Occurrence Handle11250004 Occurrence Handle1:CAS:528:DC%2BD3MXhvVWrtbg%3D

    PubMed  CAS  Google Scholar 

  • L Kobzik MB Reid DS Bredt JS Stamler (1994) ArticleTitleNitric oxide in skeletal muscle Nature 372 546–548 Occurrence Handle7527495 Occurrence Handle1:CAS:528:DyaK2M**sFKktLo%3D

    PubMed  CAS  Google Scholar 

  • SB Kombian M Hirasawa D Mouginot QJ Pittman (2002) ArticleTitleModulation of synaptic transmission by oxytocin and vasopressin in the supraoptic nucleus Prog Brain Res 139 235–246 Occurrence Handle12436939 Occurrence Handle1:CAS:528:DC%2BD38XovFGrs7Y%3D

    PubMed  CAS  Google Scholar 

  • SB Kombian D Mouginot M Hirasawa QJ Pittman (2000) ArticleTitleVasopressin preferentially depresses excitatory over inhibitory synaptic transmission in the rat supraoptic nucleus in vitro J Neuroendocrinol 12 361–367 Occurrence Handle10718934 Occurrence Handle1:CAS:528:DC%2BD3c**sVahtb4%3D

    PubMed  CAS  Google Scholar 

  • JM Koolhaas SM Korte SF De Boer BJ Van Der Vegt CG Van Reenen H Hopster IC De Jong MA Ruis HJ Blokhuis (1999) ArticleTitleCo** styles in animals: current status in behavior and stress-physiology Neurosci Biobehav Rev 23 925–935 Occurrence Handle10580307 Occurrence Handle1:STN:280:DC%2BD3c%2Fks1amsA%3D%3D

    PubMed  CAS  Google Scholar 

  • SM Korte (2001) ArticleTitleCorticosteroids in relation to fear, anxiety and psychopathology Neurosci Biobehav Rev 25 117–142 Occurrence Handle11323078 Occurrence Handle1:CAS:528:DC%2BD3M**vFarur0%3D

    PubMed  CAS  Google Scholar 

  • R Landgraf M Ludwig (1991) ArticleTitleVasopressin release within the supraoptic and paraventricular nuclei of the rat brain: osmotic stimulation via microdialysis Brain Res 558 191–196 Occurrence Handle1782541 Occurrence Handle1:CAS:528:DyaK3MXlvF2jtbs%3D

    PubMed  CAS  Google Scholar 

  • R Landgraf ID Neumann (2004) ArticleTitleVasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication Front Neuroendocrinol 25 150–176 Occurrence Handle15589267 Occurrence Handle1:CAS:528:DC%2BD2cXhtVKltL%2FI

    PubMed  CAS  Google Scholar 

  • KL Lau SK Kong WH Ko HY Kwan Y Huang X Yao (2003) ArticleTitlecGMP stimulates endoplasmic reticulum Ca(2+)-ATPase in vascular endothelial cells Life Sci 73 2019–2028 Occurrence Handle12899926 Occurrence Handle1:CAS:528:DC%2BD3sXlvFyns74%3D

    PubMed  CAS  Google Scholar 

  • RS Lazarus A DeLongis S Folkman R Gruen (1985) ArticleTitleStress and adaptational outcomes. The problem of confounded measures Am Psychol 40 770–785 Occurrence Handle4037513 Occurrence Handle1:STN:280:DyaL2MzgsFWiuw%3D%3D

    PubMed  CAS  Google Scholar 

  • S Lee CK Kim C Rivier (1999) ArticleTitleNitric oxide stimulates ACTH secretion and the transcription of the genes encoding for NGFI-B, corticotropin-releasing factor, corticotropin-releasing factor receptor type 1, and vasopressin in the hypothalamus of the intact rat J Neurosci 19 7640–7647 Occurrence Handle10460269 Occurrence Handle1:CAS:528:DyaK1MXlslWmsLo%3D

    PubMed  CAS  Google Scholar 

  • MO Lopez-Figueroa HE Day H Akil SJ Watson (1998) ArticleTitleNitric oxide in the stress axis Histol Histopathol 13 1243–1252 Occurrence Handle9810515 Occurrence Handle1:CAS:528:DyaK1cXnslGltb4%3D

    PubMed  CAS  Google Scholar 

  • M Ludwig MF Callahan I Neumann R Landgraf M Morris (1994) ArticleTitleSystemic osmotic stimulation increases vasopressin and oxytocin release within the supraoptic nucleus J Neuroendocrinol 6 369–373 Occurrence Handle7987366 Occurrence Handle1:CAS:528:DyaK2cXlvFKgsbo%3D

    PubMed  CAS  Google Scholar 

  • M Ludwig G Leng (1998) ArticleTitleIntrahypothalamic vasopressin release. An inhibitor of systemic vasopressin secretion? Adv Exp Med Biol 449 163–173 Occurrence Handle10026799 Occurrence Handle1:CAS:528:DC%2BD3c**tVOgtLk%3D

    PubMed  CAS  Google Scholar 

  • M Ludwig K Williams MF Callahan M Morris (1996) ArticleTitleSalt loading abolishes osmotically stimulated vasopressin release within the supraoptic nucleus Neurosci Lett 215 1–4 Occurrence Handle8880739 Occurrence Handle1:CAS:528:DyaK28XlslCrtbo%3D

    PubMed  CAS  Google Scholar 

  • XM Ma SL Lightman (1998) ArticleTitleThe arginine vasopressin and corticotrophin-releasing hormone gene transcription responses to varied frequencies of repeated stress in rats J Physiol 510 605–614 Occurrence Handle9706007 Occurrence Handle1:CAS:528:DyaK1cXltlCgurk%3D

    PubMed  CAS  Google Scholar 

  • T Magee AM Fuentes H Garban T Rajavashisth D Marquez JA Rodriguez J Rajfer NF Gonzalez-Cadavid (1996) ArticleTitleCloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract Biochem Biophys Res Commun 226 145–151 Occurrence Handle8806605 Occurrence Handle1:CAS:528:DyaK28XlsVKntbc%3D

    PubMed  CAS  Google Scholar 

  • GB Makara FA Antoni E Stark (1982) ArticleTitleElectrical stimulation in the rat of the supraoptic nucleus: failure to alter plasma corticosterone after surgical lesioning of the paraventricular nucleus Neurosci Lett 30 269–273 Occurrence Handle7110634 Occurrence Handle1:CAS:528:DyaL38XkvVKjs70%3D

    PubMed  CAS  Google Scholar 

  • GB Makara J Haller (2001) ArticleTitleNon-genomic effects of glucocorticoids in the neural system. Evidence, mechanisms and implications Prog Neurobiol 65 367–390 Occurrence Handle11527573 Occurrence Handle1:CAS:528:DC%2BD3MXmt1yjt7k%3D

    PubMed  CAS  Google Scholar 

  • S Makino MA Smith PW Gold (1995) ArticleTitleIncreased expression of corticotropin-releasing hormone and vasopressin messenger ribonucleic acid (mRNA) in the hypothalamic paraventricular nucleus during repeated stress: association with reduction in glucocorticoid receptor mRNA levels Endocrinology 136 3299–3309 Occurrence Handle7628364 Occurrence Handle1:CAS:528:DyaK2MXntFKnsb0%3D

    PubMed  CAS  Google Scholar 

  • PD Marley J McLeod C Anderson KA Thomson (1995) ArticleTitleNerves containing nitric oxide synthase and their possible function in the control of catecholamine secretion in the bovine adrenal medulla J Auton Nerv Syst 54 184–194 Occurrence Handle7490420 Occurrence Handle1:CAS:528:DyaK2MXosFegt7k%3D

    PubMed  CAS  Google Scholar 

  • PA Marsden HH Heng SW Scherer RJ Stewart AV Hall XM Shi LC Tsui KT Schappert (1993) ArticleTitleStructure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene J Biol Chem 268 17478–17488 Occurrence Handle7688726 Occurrence Handle1:CAS:528:DyaK3sXmsVansrg%3D

    PubMed  CAS  Google Scholar 

  • L Martini C Monpurgo (1955) ArticleTitleNeurohumoral control of the release of adrenocorticotrophic hormone Nature 175 1127–1128 Occurrence Handle14394125 Occurrence Handle1:STN:280:DyaG2M%2Fps1Sisg%3D%3D

    PubMed  CAS  Google Scholar 

  • S McCann JR Brobeck (1954) ArticleTitleEvidence for a role of the supraopticohypophyseal system in regulation of adrenocorticotrophin secretion Proc Soc Exp Biol Med 87 318–324 Occurrence Handle13237230 Occurrence Handle1:CAS:528:DyaG2MXht1OrtA%3D%3D

    PubMed  CAS  Google Scholar 

  • TM McLeod AL Lopez-Figueroa MO Lopez-Figueroa (2001) ArticleTitleNitric oxide, stress, and depression Psychopharmacol Bull 35 24–41 Occurrence Handle12397868 Occurrence Handle1:STN:280:DC%2BD38njvFSksg%3D%3D

    PubMed  CAS  Google Scholar 

  • IA Mirsky M Stein G Paulisch (1954) ArticleTitleThe secretion of an antidiuretic substance into the circulation of adrenalectomized and hypophysectomized rats exposed to noxious stimuli Endocrinology 55 28–39 Occurrence Handle13173411 Occurrence Handle1:CAS:528:DyaG2MXmtFemtg%3D%3D Occurrence Handle10.1210/endo-55-1-28

    Article  PubMed  CAS  Google Scholar 

  • CE Mohn J Fernandez-Solari A De Laurentiis JP Prestifilippo C de la Cal R Funk SR Bornstein SM McCann V Rettori (2005) ArticleTitleThe rapid release of corticosterone from the adrenal induced by ACTH is mediated by nitric oxide acting by prostaglandin E2 Proc Natl Acad Sci USA 102 6213–6218 Occurrence Handle15837925 Occurrence Handle1:CAS:528:DC%2BD2MXkt1ClsLk%3D

    PubMed  CAS  Google Scholar 

  • BB Nankova EL Sabban (1999) ArticleTitleMultiple signalling pathways exist in the stress-triggered regulation of gene expression for catecholamine biosynthetic enzymes and several neuropeptides in the rat adrenal medulla Acta Physiol Scand 167 1–9 Occurrence Handle10519971 Occurrence Handle1:CAS:528:DyaK1MXmsVygt7c%3D

    PubMed  CAS  Google Scholar 

  • I Neumann JA Russell R Landgraf (1993) ArticleTitleOxytocin and vasopressin release within the supraoptic and paraventricular nuclei of pregnant, parturient and lactating rats: a microdialysis study Neuroscience 53 65–75 Occurrence Handle8469313 Occurrence Handle1:CAS:528:DyaK3s**tVGmu78%3D

    PubMed  CAS  Google Scholar 

  • ID Neumann (2002) ArticleTitleInvolvement of the brain oxytocin system in stress co**: interactions with the hypothalamo-pituitary-adrenal axis Prog Brain Res 139 147–162 Occurrence Handle12436933 Occurrence Handle1:CAS:528:DC%2BD38XovFGrsrk%3D

    PubMed  CAS  Google Scholar 

  • ID Neumann SA Kromer N Toschi K Ebner (2000a) ArticleTitleBrain oxytocin inhibits the (re)activity of the hypothalamo-pituitary-adrenal axis in male rats: involvement of hypothalamic and limbic brain regions Regul Pept 96 31–38 Occurrence Handle1:CAS:528:DC%2BD3cXotlCru7w%3D

    CAS  Google Scholar 

  • ID Neumann A Wigger L Torner F Holsboer R Landgraf (2000b) ArticleTitleBrain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: partial action within the paraventricular nucleus J Neuroendocrinol 12 235–243 Occurrence Handle1:CAS:528:DC%2BD3c**sVSgtr0%3D

    CAS  Google Scholar 

  • M Nomura M Tsutsui H Shimokawa N Fujimoto Y Ueta T Morishita N Yanagihara T Matsumoto (2005) ArticleTitleEffects of nitric oxide synthase isoform deletion on oxytocin and vasopressin messenger RNA in mouse hypothalamus Neuroreport 16 413–417 Occurrence Handle15729148 Occurrence Handle1:CAS:528:DC%2BD2MXhsF2ltro%3D

    PubMed  CAS  Google Scholar 

  • A Nylen G Skagerberg P Alm B Larsson B Holmqvist KE Andersson (2001) ArticleTitleNitric oxide synthase in the hypothalamic paraventricular nucleus of the female rat; organization of spinal projections and coexistence with oxytocin or vasopressin Brain Res 908 10–24 Occurrence Handle11457427 Occurrence Handle1:CAS:528:DC%2BD3MXltFyqsbY%3D

    PubMed  CAS  Google Scholar 

  • GF Orlando K Langnaese R Landgraf MG Spina G Wolf M Engelmann (2007) ArticleTitleNeural nitric oxide gene inactivation affects the release profile of oxytocin into the blood in response to forced swimming Nitric Oxide 16 64–70 Occurrence Handle16769231 Occurrence Handle1:CAS:528:DC%2BD28Xht1Kgu7zE

    PubMed  CAS  Google Scholar 

  • GF Orlando K Langnaese C Schulz G Wolf M Engelmann (2008) ArticleTitleNeuronal nitric oxide synthase gene inactivation reduces the expression of vasopressin in the hypothalamic paraventricular nucleus and of catecholamine biosynthetic enzymes in the adrenal gland of the mouse Stress 11 42–51 Occurrence Handle1:CAS:528:DC%2BD1cXovVSl Occurrence Handle17853069

    CAS  PubMed  Google Scholar 

  • MJ Oset-Gasque M Parramon S Hortelano L Bosca MP Gonzalez (1994) ArticleTitleNitric oxide implication in the control of neurosecretion by chromaffin cells J Neurochem 63 1693–1700 Occurrence Handle7523598 Occurrence Handle1:CAS:528:DyaK2cXmsVOjsL8%3D Occurrence Handle10.1046/j.1471-4159.1994.63051693.x

    Article  PubMed  CAS  Google Scholar 

  • MJ Oset-Gasque S Vicente MP Gonzalez LM Rosario E Castro (1998) ArticleTitleSegregation of nitric oxide synthase expression and calcium response to nitric oxide in adrenergic and noradrenergic bovine chromaffin cells Neuroscience 83 271–280 Occurrence Handle9466416 Occurrence Handle1:CAS:528:DyaK1c**tVOltQ%3D%3D

    PubMed  CAS  Google Scholar 

  • JE Ottenweller AH Meier (1982) ArticleTitleAdrenal innervation may be an extrapituitary mechanism able to regulate adrenocortical rhythmicity in rats Endocrinology 111 1334–1338 Occurrence Handle6288356 Occurrence Handle1:CAS:528:DyaL38XlslGntrs%3D

    PubMed  CAS  Google Scholar 

  • QJ Pittman M Hirasawa D Mouginot SB Kombian (2000) ArticleTitleNeurohypophysial peptides as retrograde transmitters in the supraoptic nucleus of the rat Exp Physiol 85 139S–143S Occurrence Handle10795916 Occurrence Handle1:CAS:528:DC%2BD3cXjtVOiurY%3D

    PubMed  CAS  Google Scholar 

  • PM Plotsky S Otto S Sutton (1987) ArticleTitleNeurotransmitter modulation of corticotropin releasing factor secretion into the hypophysial-portal circulation Life Sci 41 1311–1317 Occurrence Handle3498106 Occurrence Handle1:CAS:528:DyaL2sXltV2ktLY%3D

    PubMed  CAS  Google Scholar 

  • S Pogun V Dawson MJ Kuhar (1994) ArticleTitleNitric oxide inhibits 3H-glutamate transport in synaptosomes Synapse 18 21–26 Occurrence Handle7825120 Occurrence Handle1:CAS:528:DyaK2cXmt1altrk%3D

    PubMed  CAS  Google Scholar 

  • DV Pow JF Morris (1989) ArticleTitleDendrites of hypothalamic magnocellular neurons release neurohypophyseal peptides by exocytosis Neuroscience 32 435–439 Occurrence Handle2586758 Occurrence Handle1:CAS:528:DyaK3MXnvFw%3D

    PubMed  CAS  Google Scholar 

  • N Reiling R Kroncke AJ Ulmer J Gerdes HD Flad S Hauschildt (1996) ArticleTitleNitric oxide synthase: expression of the endothelial, Ca2+/calmodulin-dependent isoform in human B and T lymphocytes Eur J Immunol 26 511–516 Occurrence Handle8605914 Occurrence Handle1:CAS:528:DyaK28XhvVGntr8%3D

    PubMed  CAS  Google Scholar 

  • V Rettori G Canteros R Renoso M Gimeno SM McCann (1997) ArticleTitleOxytocin stimulates the release of luteinizing hormone-releasing hormone from medial basal hypothalamic explants by releasing nitric oxide Proc Natl Acad Sci USA 94 2741–2744 Occurrence Handle9122267 Occurrence Handle1:CAS:528:DyaK2sXhvF2kt7k%3D

    PubMed  CAS  Google Scholar 

  • W Riedel (2000) ArticleTitleRole of nitric oxide in the control of the hypothalamic-pituitary-adrenocortical axis Z Rheumatol 59 IssueIDSuppl 2 36–42

    Google Scholar 

  • C Rivier GH Shen (1994) ArticleTitleIn the rat, endogenous nitric oxide modulates the response of the hypothalamic-pituitary-adrenal axis to interleukin-1 beta, vasopressin, and oxytocin J Neurosci 14 1985–1993 Occurrence Handle8158253 Occurrence Handle1:CAS:528:DyaK2c**vFSgtbY%3D

    PubMed  CAS  Google Scholar 

  • F Rodriguez-Pascual MT Miras-Portugal M Torres (1995) ArticleTitleCyclic GMP-dependent protein kinase activation mediates inhibition of catecholamines secretion and Ca2+ influx in bovine chromaffin cells Neuroscience 67 149–157 Occurrence Handle7477895 Occurrence Handle1:CAS:528:DyaK2MXmtFOit7Y%3D

    PubMed  CAS  Google Scholar 

  • F Rodriguez-Pascual MT Miras-Portugal M Torres (1996) ArticleTitleEffect of cyclic GMP-increasing agents nitric oxide and C-type natriuretic peptide on bovine chromaffin cell function: inhibitory role mediated by cyclic GMP-dependent protein kinase Mol Pharmacol 49 1058–1070 Occurrence Handle8649344 Occurrence Handle1:CAS:528:DyaK28Xjs12js74%3D

    PubMed  CAS  Google Scholar 

  • P Salchner G Lubec M Engelmann GF Orlando G Wolf SB Sartori H Hoeger N Singewald (2004) ArticleTitleGenetic functional inactivation of neuronal nitric oxide synthase affects stress-related Fos expression in specific brain regions Cell Mol Life Sci 61 1498–1506 Occurrence Handle15197473 Occurrence Handle1:CAS:528:DC%2BD2cXmtFSku7g%3D

    PubMed  CAS  Google Scholar 

  • SF Schlosser OF Almeida VK Patchev A Yassouridis J Elands (1994) ArticleTitleOxytocin-stimulated release of adrenocorticotropin from the rat pituitary is mediated by arginine vasopressin receptors of the V1b type Endocrinology 135 2058–2063 Occurrence Handle7956927 Occurrence Handle1:CAS:528:DyaK2cXmvFehs7o%3D

    PubMed  CAS  Google Scholar 

  • PM Schwarz F Rodriguez-Pascual D Koesling M Torres U Forstermann (1998) ArticleTitleFunctional coupling of nitric oxide synthase and soluble guanylyl cyclase in controlling catecholamine secretion from bovine chromaffin cells Neuroscience 82 255–265 Occurrence Handle9483518 Occurrence Handle1:CAS:528:DyaK2sXmvFCqtLs%3D

    PubMed  CAS  Google Scholar 

  • LV Scott TG Dinan (1998) ArticleTitleVasopressin and the regulation of hypothalamic-pituitary-adrenal axis function: implications for the pathophysiology of depression Life Sci 62 1985–1998 Occurrence Handle9627097 Occurrence Handle1:CAS:528:DyaK1c**slajtLc%3D

    PubMed  CAS  Google Scholar 

  • H Selye (1955) ArticleTitleStress and disease Science 122 625–631 Occurrence Handle13255902 Occurrence Handle1:STN:280:DyaG28%2FgslOmtg%3D%3D

    PubMed  CAS  Google Scholar 

  • H Selye (1998) ArticleTitleA syndrome produced by diverse nocuous agents, 1936 J Neuropsych Clin Neurosci 10 230–231 Occurrence Handle1:STN:280:DyaK1czotlCgtQ%3D%3D

    CAS  Google Scholar 

  • CI Shelton (2004) ArticleTitleDiagnosis and management of anxiety disorders J Am Osteopathol Assoc 104 S2–S5

    Google Scholar 

  • Y Shimizu M Sakai Y Umemura H Ueda (1997) ArticleTitleImmunohistochemical localization of nitric oxide synthase in normal human skin: expression of endothelial-type and inducible-type nitric oxide synthase in keratinocytes J Dermatol 24 80–87 Occurrence Handle9065701 Occurrence Handle1:CAS:528:DyaK2s**sFWltLY%3D

    PubMed  CAS  Google Scholar 

  • P Siaud M Mekaouche G Ixart M Balmefrezol L Givalois G Barbanel I Assenmacher (1994) ArticleTitleA subpopulation of corticotropin-releasing hormone neurosecretory cells in the paraventricular nucleus of the hypothalamus also contain NADPH-diaphorase Neurosci Lett 170 51–54 Occurrence Handle8041513 Occurrence Handle1:CAS:528:DyaK2cXktVWgtb0%3D

    PubMed  CAS  Google Scholar 

  • A Strohle F Holsboer (2003) ArticleTitleStress responsive neurohormones in depression and anxiety Pharmacopsychiatry 36 IssueIDSuppl 3 S207–S214 Occurrence Handle14677081

    PubMed  Google Scholar 

  • JY Summy-Long V Bui S Mantz E Koehler J Weisz M Kadekaro (1993) ArticleTitleCentral inhibition of nitric oxide synthase preferentially augments release of oxytocin during dehydration Neurosci Lett 152 190–193 Occurrence Handle7685865 Occurrence Handle1:CAS:528:DyaK3sXksVWgsL8%3D

    PubMed  CAS  Google Scholar 

  • LW Swanson (1987) The hypothalamus Elsevier Amsterdam 1–124

    Google Scholar 

  • LW Swanson PE Sawchenko (1980) ArticleTitleParaventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanisms Neuroendocrinology 31 410–417 Occurrence Handle6109264 Occurrence Handle1:STN:280:DyaL3M%2FpvFahug%3D%3D

    PubMed  CAS  Google Scholar 

  • K Tanaka T Chiba (1996) ArticleTitleUltrastructural localization of nerve terminals containing nitric oxide synthase in rat adrenal gland Neurosci Lett 204 153–156 Occurrence Handle8938253 Occurrence Handle1:CAS:528:DyaK28Xht1WktLg%3D

    PubMed  CAS  Google Scholar 

  • G Torres S Lee C Rivier (1993) ArticleTitleOntogeny of the rat hypothalamic nitric oxide synthase and colocalizatio with neuropeptides Mol Cell Neurosci 4 155–163 Occurrence Handle1:CAS:528:DyaK3sXksVWgsLw%3D Occurrence Handle19912918

    CAS  PubMed  Google Scholar 

  • T Tsuchiya J Kishimoto Y Nakayama (1996) ArticleTitleMarked increases in neuronal nitric oxide synthase (nNOS) mRNA and NADPH-diaphorase histostaining in adrenal cortex after immobilization stress in rats Psychoneuroendocrinology 21 287–293 Occurrence Handle8817727 Occurrence Handle1:CAS:528:DyaK28XkvFSntLY%3D

    PubMed  CAS  Google Scholar 

  • Y Uchiyama K Morita S Kitayama T Suemitsu N Minami T Miyasako T Dohi (1994) ArticleTitlePossible involvement of nitric oxide in acetylcholine-induced increase of intracellular Ca2+ concentration and catecholamine release in bovine adrenal chromaffin cells Jpn J Pharmacol 65 73–77 Occurrence Handle8089933 Occurrence Handle1:CAS:528:DyaK2cXktVWksro%3D

    PubMed  CAS  Google Scholar 

  • AB Vaandrager HR de Jonge (1996) ArticleTitleSignalling by cGMP-dependent protein kinases Mol Cell Biochem 157 23–30 Occurrence Handle8739225 Occurrence Handle1:CAS:528:DyaK28Xjt1arsLY%3D

    PubMed  CAS  Google Scholar 

  • W Vale J Spiess C Rivier J Rivier (1981) ArticleTitleCharacterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin Science 213 1394–1397 Occurrence Handle6267699 Occurrence Handle1:CAS:528:DyaL3MXlvF2htbc%3D

    PubMed  CAS  Google Scholar 

  • JG Valtschanoff RJ Weinberg (2001) ArticleTitleLaminar organization of the NMDA receptor complex within the postsynaptic density J Neurosci 21 1211–1217 Occurrence Handle11160391 Occurrence Handle1:CAS:528:DC%2BD3MXhtFersLw%3D

    PubMed  CAS  Google Scholar 

  • RR Ventura A Giusti-Paiva DA Gomes LL Elias J Antunes-Rodrigues (2005) ArticleTitleNeuronal nitric oxide synthase inhibition differentially affects oxytocin and vasopressin secretion in salt loaded rats Neurosci Lett 379 75–80 Occurrence Handle15823420 Occurrence Handle1:CAS:528:DC%2BD2MXjt1Khsb4%3D

    PubMed  CAS  Google Scholar 

  • ES Waldkirch S Uckert K Langnase K Richter U Jonas G Wolf KE Andersson CG Stief P Hedlund (2007) ArticleTitleImmunohistochemical distribution of cyclic GMP-dependent protein kinase-1 in human prostate tissue Eur Urol 52 495–501 Occurrence Handle17329019 Occurrence Handle1:CAS:528:DC%2BD2sXpsFKlur8%3D

    PubMed  CAS  Google Scholar 

  • U Walter (1981) ArticleTitleDistribution of cyclic-GMP-dependent protein kinase in various rat tissues and cell lines determined by a sensitive and specific radioimmunoassay Eur J Biochem 118 339–346 Occurrence Handle6269853 Occurrence Handle1:CAS:528:DyaL3MXltFagtb8%3D Occurrence Handle10.1111/j.1432-1033.1981.tb06408.x

    Article  PubMed  CAS  Google Scholar 

  • H Wang HC Christian JF Morris (1997) ArticleTitleDissociation of nitric oxide synthase immunoreactivity and NADPH-diaphorase enzyme activity in rat pituitary J Endocrinol 154 7–11

    Google Scholar 

  • R Wang A Ghahary YJ Shen PG Scott EE Tredget (1996) ArticleTitleHuman dermal fibroblasts produce nitric oxide and express both constitutive and inducible nitric oxide synthase isoforms J Invest Dermatol 106 419–427 Occurrence Handle8648170 Occurrence Handle1:CAS:528:DyaK28**sFygu7g%3D

    PubMed  CAS  Google Scholar 

  • LE Ward LW Hunter CE Grabau GM Tyce DK Rorie (1996) ArticleTitleNitric oxide reduces basal efflux of catecholamines from perfused dog adrenal glands J Auton Nerv Syst 61 235–242 Occurrence Handle8988480

    PubMed  Google Scholar 

  • R Weitzdoerfer H Hoeger E Engidawork M Engelmann N Singewald G Lubec B Lubec (2004) ArticleTitleNeuronal nitric oxide synthase knock-out mice show impaired cognitive performance Nitric Oxide 10 130–140 Occurrence Handle15158692 Occurrence Handle1:CAS:528:DC%2BD2cXkt1ajtr0%3D

    PubMed  CAS  Google Scholar 

  • G Wolf (1997) ArticleTitleNitric oxide and nitric oxide synthase: biology, pathology, localization Histol Histopathol 12 251–261 Occurrence Handle9046060 Occurrence Handle1:CAS:528:DyaK2s**tlOmt7g%3D

    PubMed  CAS  Google Scholar 

  • J Wood J Garthwaite (1994) ArticleTitleModels of the diffusional spread of nitric oxide: implications for neural nitric oxide signalling and its pharmacological properties Neuropharmacology 33 1235–1244 Occurrence Handle7870284 Occurrence Handle1:CAS:528:DyaK2cXmvFOqsb8%3D

    PubMed  CAS  Google Scholar 

  • CT Wotjak J Ganster G Kohl F Holsboer R Landgraf M Engelmann (1998) ArticleTitleDissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: new insights into the secretory capacities of peptidergic neurons Neuroscience 85 1209–1222 Occurrence Handle9681958 Occurrence Handle1:CAS:528:DyaK1cXjvVehtbw%3D

    PubMed  CAS  Google Scholar 

  • CT Wotjak M Kubota G Kohl R Landgraf (1996) ArticleTitleRelease of vasopressin from supraoptic neurons within the median eminence in vivo. A combined microdialysis and push-pull perfusion study in the rat Brain Res 726 237–241 Occurrence Handle8836567 Occurrence Handle1:CAS:528:DyaK28XjvFGjsbs%3D

    PubMed  CAS  Google Scholar 

  • CT Wotjak M Ludwig K Ebner JA Russell N Singewald R Landgraf M Engelmann (2002) ArticleTitleVasopressin from hypothalamic magnocellular neurons has opposite actions at the adenohypophysis and in the supraoptic nucleus on ACTH secretion Eur J Neurosci 16 477–485 Occurrence Handle12193191

    PubMed  Google Scholar 

  • CT Wotjak T Naruo S Muraoka R Simchen R Landgraf M Engelmann (2001) ArticleTitleForced swimming stimulates the expression of vasopressin and oxytocin in magnocellular neurons of the rat hypothalamic paraventricular nucleus Eur J Neurosci 13 2273–2281 Occurrence Handle11454031 Occurrence Handle1:STN:280:DC%2BD3Mvgtlantg%3D%3D

    PubMed  CAS  Google Scholar 

  • QW **e HJ Cho J Calaycay RA Mumford KM Swiderek TD Lee A Ding T Troso C Nathan (1992) ArticleTitleCloning and characterization of inducible nitric oxide synthase from mouse macrophages Science 256 225–228 Occurrence Handle1373522 Occurrence Handle1:CAS:528:DyaK38XksVent7Y%3D

    PubMed  CAS  Google Scholar 

  • KY Xu DL Huso TM Dawson DS Bredt LC Becker (1999) ArticleTitleNitric oxide synthase in cardiac sarcoplasmic reticulum Proc Natl Acad Sci USA 96 657–662 Occurrence Handle9892689 Occurrence Handle1:CAS:528:DyaK1MXmtlCktQ%3D%3D

    PubMed  CAS  Google Scholar 

  • C Xue J Pollock HH Schmidt SM Ward KM Sanders (1994) ArticleTitleExpression of nitric oxide synthase immunoreactivity by interstitial cells of the canine proximal colon J Auton Nerv Syst 49 1–14 Occurrence Handle7525687 Occurrence Handle1:CAS:528:DyaK2cXmvFOmu78%3D

    PubMed  CAS  Google Scholar 

  • R Yehuda EL Giller SM Southwick MT Lowy JW Mason (1991) ArticleTitleHypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder Biol Psychiatry 30 1031–1048 Occurrence Handle1661614 Occurrence Handle1:CAS:528:DyaK38**tFWqsrw%3D

    PubMed  CAS  Google Scholar 

  • Q Yuan DE Scott KF So W Wu (2006) ArticleTitleDevelopmental changes of nitric oxide synthase expression in the rat hypothalamoneurohypophyseal system Anat Rec A Discov Mol Cell Evol Biol 288 36–45 Occurrence Handle16342209

    PubMed  Google Scholar 

  • RE Zigmond MA Schwarzschild AR Rittenhouse (1989) ArticleTitleAcute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation Annu Rev Neurosci 12 415–461 Occurrence Handle2564757 Occurrence Handle1:CAS:528:DyaL1MXhvVKjtr8%3D

    PubMed  CAS  Google Scholar 

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  1. Institute of Medical Neurobiology, Otto von Guericke University, Magdeburg, Germany

    G. F. Orlando, G. Wolf & M. Engelmann

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  1. G. F. Orlando
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  2. G. Wolf
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  3. M. Engelmann
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Authors’ address: Dr. Gabriella Orlando, Medizinische Fakultät, Institut für Molekulare und Klinische Immunologie, Universitätsklinikum Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Deutschland

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Orlando, G., Wolf, G. & Engelmann, M. Role of neuronal nitric oxide synthase in the regulation of the neuroendocrine stress response in rodents: insights from mutant mice. Amino Acids 35, 17–27 (2008). https://doi.org/10.1007/s00726-007-0630-0

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