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Synthesis of copper nanorods for non-enzymatic amperometric sensing of glucose

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Abstract

An electrochemical non-enzymatic glucose sensor based on copper nanorods (CuNRs) was developed. The CuNRs were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction spectroscopy, and X-ray photoelectron spectroscopy. The results display a layer of rough cuprous oxide that is formed on the surface of CuNRs. The CuNR- modified glassy carbon electrode exhibits an outstanding capability in terms of nonenzymatic sensing of glucose. The sensor displays high sensitivity (1490 μA•mM−1•cm−2), fast response time (less than 5 s), a low detection limit of 8 nM (S/N = 3), long term stability, and excellent anti-fouling ability. The sensor was applied to the detection of glucose in (spiked) human serum and in black ice tea, with relative standard deviations (for n = 6) of 1.7 % and 1.9 %, respectively.

The surface of Cu nanorods was covered with cuprous oxide, which increased the surface area of the nanorods and provided more catalytic active sites for the electro-oxidation of glucose. Good linearity and selectivity were obtained in glucose sensing.

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Acknowledgments

We acknowledge financial support from the Ministry of Science and Technology of China (No. 2013YQ170585).

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Authors and Affiliations

  1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China

    **angjian Liu, Wenxiu Yang, Lulu Chen & Jianbo Jia

  2. University of Chinese Academy of Sciences, Bei**g, 100049, China

    **angjian Liu, Wenxiu Yang & Lulu Chen

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  1. **angjian Liu
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  2. Wenxiu Yang
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  3. Lulu Chen
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  4. Jianbo Jia
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Correspondence to Jianbo Jia.

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Liu, X., Yang, W., Chen, L. et al. Synthesis of copper nanorods for non-enzymatic amperometric sensing of glucose. Microchim Acta 183, 2369–2375 (2016). https://doi.org/10.1007/s00604-016-1878-4

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