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Chemiluminescence method for the determination of mitoxantrone by the enhancement of the tris-(4,7-diphenyl-1,10-phenanthrolinedisulfonic acid)ruthenium(II)–cerium(IV) system

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Abstract.

A new injection chemiluminescence system was used for the determination of mitoxantrone. The technique is based on the reduction effect of mitoxantrone on the tris-(4,7-diphenyl-1,10-phenanthrolinedisulfonic acid)ruthenium(II), which is produced by reaction between tris-(4,7-diphenyl-1,10-phenanthrolinedisulfonic acid)ruthenium(II) and acidic cerium(IV) solutions, and this rapid reduction produces strong chemiluminescence. The chemiluminescence intensity was so high that it is able to produce a detection limit of 1.4 × 10−8 mol L−1 mitoxantrone (3σ). The relative standard deviation of 1.0 × 10−6 mol L−1 mitoxantrone was 1.9% (n = 11). The method was successfully applied to the determination of mitoxantrone in pharmaceutical preparations in capsule, spiked serum and urine samples.

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Authors and Affiliations

  1. Department of Chemistry, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan, P.R. China

    Fengshan Yu & Fang Chen

  2. Department of Chemistry, Huaibei Coal Industry Teachers’ College, Huaibei, P.R. China

    Lanhua Chen

Authors
  1. Fengshan Yu
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  2. Lanhua Chen
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  3. Fang Chen
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Correspondence to Lanhua Chen.

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Correspondence: Lanhua Chen, Department of Chemistry, Huaibei Coal Industry Teachers’ College, Huaibei 235000, P.R. China

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Yu, F., Chen, L. & Chen, F. Chemiluminescence method for the determination of mitoxantrone by the enhancement of the tris-(4,7-diphenyl-1,10-phenanthrolinedisulfonic acid)ruthenium(II)–cerium(IV) system. Microchim Acta 161, 185–190 (2008). https://doi.org/10.1007/s00604-007-0936-3

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  • DOI: https://doi.org/10.1007/s00604-007-0936-3

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