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Well differentiated carcinoma with a poor prognosis: a retrospective analysis of papillary gastric adenocarcinoma

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Abstract

Purpose

To explore the clinicopathological features and prognosis of papillary gastric adenocarcinoma (PGC).

Methods

The subjects of this retrospective analysis were 1525 patients with gastric cancer in a single center in China.

Results

The patients with PGC were generally of advanced age and the tumor was located in the upper 1/3 of the stomach. PGC was well or moderately differentiated, with serosal infiltration, early lymph node metastasis, TNM stages I/II, liver metastasis, and a short postoperative overall survival time. Patients with the secondary pathological type of papillary adenocarcinoma presented with clinicopathological similarities to those with primary PGC. PGC was a risk factor for poor survival in both univariate and multivariate analyses.

Conclusion

Papillary gastric adenocarcinoma (PGC) showed different clinicopathological characteristics and prognosis to other types of gastric cancer (GC), even if it was not the primary pathological type. The higher the proportion of papillary adenocarcinoma in gastric cancer samples, the shorter the postoperative survival time of patients. PGC needs further multicenter studies.

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Acknowledgements

This study was supported in part by grants from the Programs of National Natural Science Foundation of China (No. 81572372), National Key Research and Development Program of China (2016YFC1303202), and National Precision Medicine Research Program (2017YFC0908300).

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Author notes

  1. **nyu Wang and **gyu Deng contributed equally to this work.

Authors and Affiliations

  1. Department of Gastric Cancer, Tian** Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tian**’s Clinical Research Cancer for Cancer, Tian**, 300060, China

    **nyu Wang, **gyu Deng & Han Liang

Authors
  1. **nyu Wang
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  2. **gyu Deng
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  3. Han Liang
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Correspondence to **gyu Deng or Han Liang.

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All authors are accountable for all aspects of the work. Informed consent for inclusion in the study was obtained from all patients. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Wang, X., Deng, J. & Liang, H. Well differentiated carcinoma with a poor prognosis: a retrospective analysis of papillary gastric adenocarcinoma. Surg Today 51, 1387–1396 (2021). https://doi.org/10.1007/s00595-021-02289-3

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