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An amperometric sensitive dopamine biosensor based on novel copper oxide nanostructures

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Abstract

It is highly important to explore the influence of counter anions on the morphology in order to have a desired nanostructure with unique properties. Therefore, in this research work the influence of counter anions on the morphology of copper oxide (CuO) nanostructures is presented using copper chloride and copper acetate salts. A significant role of counter anions on the morphology of CuO nanostructures is observed. The hydrothermal method is used to carry out the synthesis of CuO nanomaterial. The prepared CuO nanostructures are characterized by scanning electron microscopy and X-ray diffraction techniques. The prepared CuO nanomaterial exhibits porous nature with thin nanowires and sponge like morphologies. The dopamine sensing application was carried for exploring the electrocatalytic properties of CuO nanostructures. The presented dopamine biosensor exhibited wide linear range for detection of dopamine from 5 to 40 µM with sensitivity of 12.8 µA mM−1 cm−2. The limit of detection and limit of quantification were estimated in order 0.11 and 0.38 µM respectively. The developed dopamine biosensor is highly sensitive, selective, stable and reproducible. The common interfering species such as glucose, ascorbic acid and uric acid showed negligible change in the current when same concentration of dopamine and these interfering species was used. The fabricated biosensor could be used for the determination of dopamine from real blood samples.

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Acknowledgments

The authors also wish to extend their sincere appreciation to Scientific Research at King Saud University for funding through the Research Group Project No. RGP-VPP-236.

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Authors and Affiliations

  1. Dr. M.A.Kazi Institute of Chemistry, University of Sindh, Jamshoro, 76080, Pakistan

    Qurrat-ul-ain Baloach, Aneela Tahira & Zafar Hussain Ibupoto

  2. Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia

    Ayman Nafady

  3. Chemistry Department, Faculty of Science, Sohag University, Sohag, 82524, Egypt

    Ayman Nafady

  4. National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan

    Sirajuddin, Syed Tufail Hussain Sherazi, Tayyaba Shaikh & Munazza Arain

  5. Department of Science and Technology, Linko** University, Campus Norrko**, 60174, Norrko**, Sweden

    Magnus Willander

Authors
  1. Qurrat-ul-ain Baloach
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  2. Ayman Nafady
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  3. Aneela Tahira
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  4. Sirajuddin
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  5. Syed Tufail Hussain Sherazi
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  6. Tayyaba Shaikh
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  7. Munazza Arain
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  8. Magnus Willander
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  9. Zafar Hussain Ibupoto
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Correspondence to Zafar Hussain Ibupoto.

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Baloach, Qua., Nafady, A., Tahira, A. et al. An amperometric sensitive dopamine biosensor based on novel copper oxide nanostructures. Microsyst Technol 23, 1229–1235 (2017). https://doi.org/10.1007/s00542-015-2805-z

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  • DOI: https://doi.org/10.1007/s00542-015-2805-z

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