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Neutrophil gelatinase-associated lipocalin and liver-type fatty acid-binding protein as biomarkers for acute kidney injury after organ transplantation

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Abstract

Purpose

Neutrophil gelatinase-associated lipocalin (NGAL) and liver-type fatty acid-binding protein (L-FABP) are promising early biomarkers for acute kidney injury (AKI). In organ transplant recipients, AKI predictability based on NGAL and L-FABP remains to be elucidated. Furthermore, the association between serial NGAL and L-FABP measurements and AKI outcome is unknown. Therefore, we conducted a study to evaluate the ability of NGAL and L-FABP to predict AKI after organ transplantation and investigate the association between NGAL, L-FABP and AKI outcome.

Methods

Twenty-five organ transplant recipients admitted to the intensive care unit (ICU) immediately after transplant surgery were studied prospectively. Plasma NGAL (P-NGAL), urinary NGAL (U-NGAL) and L-FABP were measured from ICU admission to ICU discharge. U-NGAL and L-FABP were corrected for dilution/concentration by calculating U-NGAL/urine creatinine ratios (U-NGAL/Cr) and L-FABP/urine creatinine ratios (L-FABP/Cr). AKI was defined according to the Kidney Disease: Improving Global Outcomes criteria.

Results

AKI occurred in 11 patients. P-NGAL, U-NGAL/Cr and L-FABP/Cr upon ICU admission were unrelated to AKI development (p = 0.24, 0.22, and 0.53, respectively). There were no differences in P-NGAL, U-NGAL/Cr, and L-FABP/Cr levels from day 1 to day 6 between patients who did not recover from AKI and patients who recovered from AKI (p = 0.82, 0.26, and 0.61, respectively).

Conclusion

Our findings suggest that NGAL and L-FABP upon ICU admission are not predictive of AKI and serial NGAL and L-FABP measurements may be ineffective for monitoring the status and treatment of post-transplantation AKI.

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Acknowledgments

This work was supported by JSPS KAKENHI Grant, Grant-in-Aid for Young Scientists (B), number 24791592.

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Authors and Affiliations

  1. Intensive Care Unit, Osaka University Hospital, 2-15, Yamadaoka, Suita, Osaka, 565-0871, Japan

    Naoya Iguchi

  2. Department of Anesthesiology and Intensive care medicine, Osaka University Graduate School of Medicine, Osaka, Japan

    Akinori Uchiyama, Kazuyoshi Ueta & Yuji Fu**o

  3. Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan

    Yoshiki Sawa

Authors
  1. Naoya Iguchi
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  2. Akinori Uchiyama
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  3. Kazuyoshi Ueta
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  4. Yoshiki Sawa
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  5. Yuji Fu**o
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Correspondence to Naoya Iguchi.

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Iguchi, N., Uchiyama, A., Ueta, K. et al. Neutrophil gelatinase-associated lipocalin and liver-type fatty acid-binding protein as biomarkers for acute kidney injury after organ transplantation. J Anesth 29, 249–255 (2015). https://doi.org/10.1007/s00540-014-1909-4

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  • DOI: https://doi.org/10.1007/s00540-014-1909-4

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