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Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study

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Abstract

Background

Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use.

Methods

Thirty-five patients who took low-dose enteric-coated aspirin 100 mg daily (for more than 3 months) plus omeprazole 20 mg daily and were diagnosed as having unexplained iron deficiency anemia participated in this prospective randomized controlled trial. We assigned the patients to receive probiotic treatment with Lactobacillus casei for 3 months (L. casei group) or not receive the probiotic (control group). Patients underwent capsule endoscopy (CE) before and after treatment.

Results

Twenty-five patients, including 13 in the L. casei group and 12 in the control group, underwent the full analysis. Significant decreases in the number of mucosal breaks and the CE score were observed at the 3-month evaluation in the L. casei group as compared with the results in the control group (P = 0.039). The change from the baseline in the median number of mucosal breaks in the L. casei group was −2, as compared with 0.5 in the control group. The change from the baseline in the median CE score in the L. casei group was −228 compared with −4 in the control group (P = 0.026).

Conclusions

Co-administration of L. casei is effective for the treatment of aspirin-associated small bowel injury.

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Acknowledgments

This work was supported in part by Health and Labour Sciences Research Ministry of Health, Labour and Welfare of Japan to A.N.

Conflict of interest

The authors of the article have nothing to disclose.

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Authors and Affiliations

  1. Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan

    Hiroki Endo, Kunihiro Hosono, Eiji Sakai, Yusuke Sekino, Hiroshi Iida, Yasunari Sakamoto, Tomoko Koide, Hirokazu Takahashi, Masato Yoneda, Chikako Tokoro, Masahiko Inamori, Yasunobu Abe & Atsushi Nakajima

  2. Department of Gastroenterology, Yokohama Rosai Hospital, 3211 Kozukue, Kohoku-ku, Yokohama, Japan

    Takuma Higurashi

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Correspondence to Hiroki Endo.

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Endo, H., Higurashi, T., Hosono, K. et al. Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study. J Gastroenterol 46, 894–905 (2011). https://doi.org/10.1007/s00535-011-0410-1

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  • DOI: https://doi.org/10.1007/s00535-011-0410-1

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