Abstract
Background
Portal and/or splenic vein thrombosis (PSVT) is a potentially lethal complication of splenectomy for hematologic disease. Known risk factors for PSVT include malignancy and splenomegaly. While these patients are believed to be hypercoagulable, the specific mechanism is unclear. The aim of this study is to evaluate whether specific acquired prothrombotic risk factors contribute to the development of PSVT following laparoscopic splenectomy (LS).
Methods
Consecutive patients undergoing LS were prospectively studied between 2005 and 2013. Preoperatively, patients were screened for prothrombotic states and surveillance duplex ultrasonography was performed between 1 week and 1 month postoperatively to assess for PSVT. The association between baseline prothrombotic disorders and PSVT was explored using descriptive statistics.
Results
Sixty-eight patients were included in the analysis, and 17 (25 %) of these developed PSVT. There were no differences in patients with and without PSVT with respect to age, body mass index, gender or surgical time. Preoperative spleen size, as determined by diagnostic imaging, and intraoperative blood transfusion were associated with PSVT. Seven of 9 patients (78 %) with massive splenomegaly (>20 cm) developed PSVT compared with 4 of 13 patients (31 %) with moderate splenomegaly (15–20 cm) and 6 of 45 patients (13 %) without (p < 0.001). Abnormalities in baseline prothrombotic screening tests were common, with 52 patients (75 %) demonstrating at least one; however, none were associated with the development of PSVT.
Conclusion
In patients scheduled for LS, screening for prothrombotic states is not useful to identify patients at risk of development of PSVT. Preoperative spleen size and blood transfusion were predictive of PSVT formation.
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Abbreviations
- CT:
-
Computed tomography
- INR:
-
International normalized ratio
- LS:
-
Laparoscopic splenectomy
- MTHFR:
-
Methylene tetrahydrofolate reductase
- PAI-1:
-
Plasminogen activator inhibitor-1
- PSVT:
-
Portal and/or splenic venous thrombosis
- PTT:
-
Activated partial thromboplastin time
- US:
-
Ultrasound
- VTE:
-
Venous thromboembolism
- vWF:
-
von Willebrand factor
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Acknowledgments
The Steinberg-Bernstein Centre for Minimally Invasive Surgery and Innovation is supported by an unrestricted educational grant from Covidien. Dr Feldman receives research and fellowship funding from Covidien and research support from Ethicon.
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Drs. Manouchehri, Kaneva, Séguin and Artho have no conflicts of interest or financial ties to disclose.
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Manouchehri, N., Kaneva, P., Séguin, C. et al. Screening for thrombophilia does not identify patients at risk of portal or splenic vein thrombosis following laparoscopic splenectomy. Surg Endosc 30, 2119–2126 (2016). https://doi.org/10.1007/s00464-015-4476-3
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DOI: https://doi.org/10.1007/s00464-015-4476-3