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Susceptibility of neonate mice born to Schistosoma mansoni-infected and noninfected mothers to subsequent S. mansoni infection

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Abstract

The present study tested the hypothesis that prenatal exposure of neonate Outbred albino mice to Schistosoma mansoni antigens (Ags) or antibodies (Abs) modulates their immunity against postnatal responses to infection. Persistence of maternal S. mansoni Abs and/or Ags in mice born to S. mansoni-infected mothers (IF-IMs) and noninfected mothers (IF-NMs) for up to 8 weeks after delivery was investigated. A higher level of anti-S. mansoni IgG Ab was detected in sera of 1-week-old mice born to IF-IM compared to controls. Then, immunoglobulin (Ig)G gradually decreased to the eight week. No anti-S. mansoni IgM Ab was detected in sera of these offspring at any week after delivery. Schistosoma Ags were detected in liver and kidney tissues of mice born to infected mothers. However, Ags decreased markedly till the sixth week in the liver but increased significantly at the sixth week in the kidney. Eight-week-old mice born to infected and noninfected mothers were infected with 200 S. mansoni ceracriae. Their sera and livers were collected for testing IgG and granuloma formation 6 weeks postinfection. Worms were collected via portal perfusion and counted. Anti-S. mansoni IgG level, size and number of liver granuloma, and worm burden were significantly reduced in the offspring of infected mothers. These data suggest that in utero exposure of Outbred albino mice to S. mansoni may attenuate the pathogenesis of S. mansoni in subsequent challenge.

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Acknowledgements

The authors would like to thank Dr. Benjamin M. Rosenthal from the Animal Parasitic Diseases Laboratory, Agricultural Research Service, US Department of Agriculture for the critical review of the manuscript. This work was conducted in compliance with Egyptian laws.

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Authors and Affiliations

  1. Biotechnology Research Center, New Damietta City, Egypt

    A. M. Attallah

  2. Division of Biotechnology, Gastroenterology Surgery Center, College of Human Medicine, Mansoura University, Mansoura, 35516, Egypt

    Aymn T. Abbas & Hoda M. El-emshaty

  3. Department of Clinical Pathology, College of Veterinary Medicine, Cairo University, Cairo, Egypt

    Mohamed I. Dessouky

  4. Department of Parasitology, College of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt

    Hany M. Elsheikha

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  1. A. M. Attallah
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Correspondence to Hany M. Elsheikha.

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Attallah, A.M., Abbas, A.T., Dessouky, M.I. et al. Susceptibility of neonate mice born to Schistosoma mansoni-infected and noninfected mothers to subsequent S. mansoni infection. Parasitol Res 99, 137–145 (2006). https://doi.org/10.1007/s00436-006-0127-x

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