Abstract.
We examined the in vitro effect of increasing gliotoxin concentrations on the infectivity of Toxoplasma gondii for NIH-3T3 murine fibroblasts and on Toxoplasma chymotrypsin-like activity, which is specific to the proteasome. Parasite penetration of host cells was not modified by a high gliotoxin concentration (1 µM), but replication was markedly decreased (approximately 50% inhibition by 0.5 µM gliotoxin). Gliotoxin reduced the chymotrypsin-like activity of the Toxoplasma proteasome, but five times less potently than in HeLa cells.
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Paugam, A., Creuzet, C., Dupouy-Camet, J. et al. In vitro effects of gliotoxin, a natural proteasome inhibitor, on the infectivity and proteolytic activity of Toxoplasma gondii . Parasitol Res 88, 785–787 (2002). https://doi.org/10.1007/s00436-002-0644-1
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DOI: https://doi.org/10.1007/s00436-002-0644-1