Abstract
Objective
To evaluate the association between BC and urinary concentrations of free-bisphenol A (BPA-F), the biological form of BPA, among women residing in Northern Mexico.
Methods
The population under study comprised 394 histologically confirmed BC cases and 404 age-matched controls. Women were interviewed face to face about their sociodemographic and reproductive characteristics. BPA-F was determined by high-pressure liquid chromatography equipped with a fluorescence detector (HPLC/FLD). Logistic regression models were used to estimate the adjusted BC risk in relation to BPA-F.
Results
BPA-F geometric mean was significantly higher among cases compared to controls (3.16 μg/L in cases and 2.47 μg/L in controls). A significant adjusted BC odds ratio of 2.31 (95% CI: 1.43–3.74) was estimated for the highest category of BPA-F compared to the lowest category.
Conclusion
BPA-F may be an environmental cofactor of BC. Since this is the first report on BPA-F association with BC, our results need to be replicated.
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Acknowledgments
The authors thank Rosa María García Hernández and Guadalupe Lina García Hernández for their assistance in BPA extraction, Belen Barajas L. for literature search, and Luke Murphy for proofreading. This study was partially supported by CONACYT, Fondo Sectorial de Investigación en Salud y Seguridad Social 2005-2-14373, 2009-1-111384, 2010-1-140962, 2016-272632 and Proyectos de Desarrollo Científico para atender Problemas Nacionales 2013-01-215464.
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López-Carrillo, L., Mérida-Ortega, Á., Gómez-Ruiz, H. et al. Exposure to bisphenol A and breast cancer risk in northern Mexican women. Int Arch Occup Environ Health 94, 699–706 (2021). https://doi.org/10.1007/s00420-020-01590-x
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DOI: https://doi.org/10.1007/s00420-020-01590-x