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Idiopathic intracranial hypertension; research progress and emerging themes

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Abstract

Idiopathic intracranial hypertension (IIH) is a condition characterised by increased intracranial pressure of unknown cause predominantly seen in obese women of childbearing age and associated with a history of recent weight gain. The aetiology is poorly understood and there are no evidence-based guidelines on the management of the disease. We aim to provide a review of the recent literature outlining the latest advances in this field over the past few years. Areas of emerging interest related to the pathophysiology of IIH will be discussed, such as the role of obesity, adipose tissue and 11β-hydroxysteroid dehydrogenase type 1. We consider the latest research on the role of venous sinus stenosis in IIH and ex vivo advances into cerebrospinal fluid drainage via the arachnoid granulation tissue. The latest techniques for optic nerve head evaluation and the role of optical coherence tomography will be summarised. Finally, we will discuss recent advances in the management of IIH, including weight loss, and medical and surgical treatment strategies.

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References

  1. Kesler A, Goldhammer Y, Gadoth N (2001) Do men with pseudomotor cerebri share the same characteristics as women? A retrospective review of 141 cases. J Neuroophthalmol 21:15–17

    Article  CAS  PubMed  Google Scholar 

  2. WHO (2013) WHO. Global database on bodymass index. http://apps.who.int/bmi/index.jsp

  3. Raoof N, Sharrack B, Pepper IM, Hickman SJ (2011) The incidence and prevalence of idiopathic intracranial hypertension in Sheffield, UK. Eur J Neurol 18:1266–1268

    Article  CAS  PubMed  Google Scholar 

  4. Craig JJ, Mulholland DA, Gibson JM (2001) Idiopathic intracranial hypertension; incidence, presenting features and outcome in Northern Ireland (1991–1995). Ulster Med J 70:31–35

    PubMed Central  CAS  PubMed  Google Scholar 

  5. Curry WT Jr, Butler WE, Barker FG 2nd (2005) Rapidly rising incidence of cerebrospinal fluid shunting procedures for idiopathic intracranial hypertension in the United States, 1988–2002. Neurosurgery 57:97–108 discussion 197–108

    Article  PubMed  Google Scholar 

  6. Yri HM, Wegener M, Sander B, Jensen R (2012) Idiopathic intracranial hypertension is not benign: a long-term outcome study. J Neurol 259:886–894

    Article  PubMed  Google Scholar 

  7. Torbey MT, Geocadin RG, Razumovsky AY, Rigamonti D, Williams MA (2004) Utility of CSF pressure monitoring to identify idiopathic intracranial hypertension without papilledema in patients with chronic daily headache. Cephalalgia 24:495–502

    Article  CAS  PubMed  Google Scholar 

  8. Bono F, Messina D, Giliberto C, Cristiano D, Broussard G, Fera F, Condino F, Lavano A, Quattrone A (2006) Bilateral transverse sinus stenosis predicts IIH without papilledema in patients with migraine. Neurology 67:419–423

    Article  CAS  PubMed  Google Scholar 

  9. Vieira DS, Masruha MR, Goncalves AL, Zukerman E, Senne Soares CA, Naffah-Mazzacoratti Mda G, Peres MF (2008) Idiopathic intracranial hypertension with and without papilloedema in a consecutive series of patients with chronic migraine. Cephalalgia 28:609–613

    Article  CAS  PubMed  Google Scholar 

  10. Thurtell MJ, Newman NJ, Biousse V (2010) Visual loss without papilledema in idiopathic intracranial hypertension. J Neuroophthalmol 30:96–98

    Article  PubMed  Google Scholar 

  11. Dandy W (1937) Intracranial pressure without brain tumour: diagnosis and treatment. Ann Surg 106:492–513

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Smith JL (1985) Whence pseudotumor cerebri? J Clin Neuroophthalmol 5:55–56

    CAS  PubMed  Google Scholar 

  13. Friedman DI, Jacobson DM (2002) Diagnostic criteria for idiopathic intracranial hypertension. Neurology 59:1492–1495

    Article  PubMed  Google Scholar 

  14. Whiteley W, Al-Shahi R, Warlow CP, Zeidler M, Lueck CJ (2006) CSF opening pressure: reference interval and the effect of body mass index. Neurology 67:1690–1691

    Article  CAS  PubMed  Google Scholar 

  15. Corbett JJ, Savino PJ, Thompson HS, Kansu T, Schatz NJ, Orr LS, Hopson D (1982) Visual loss in pseudotumor cerebri. Follow-up of 57 patients from five to 41 years and a profile of 14 patients with permanent severe visual loss. Arch Neurol 39:461–474

    Article  CAS  PubMed  Google Scholar 

  16. Bruce BB, Kedar S, Van Stavern GP, Monaghan D, Acierno MD, Braswell RA, Preechawat P, Corbett JJ, Newman NJ, Biousse V (2009) Idiopathic intracranial hypertension in men. Neurology 72:304–309

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  17. Fraser JA, Bruce BB, Rucker J, Fraser LA, Atkins EJ, Newman NJ, Biousse V (2010) Risk factors for idiopathic intracranial hypertension in men: a case-control study. J Neurol Sci 290:86–89

    Article  PubMed Central  PubMed  Google Scholar 

  18. Bruce BB, Kedar S, Van Stavern GP, Corbett JJ, Newman NJ, Biousse V (2010) Atypical idiopathic intracranial hypertension: normal BMI and older patients. Neurology 74:1827–1832

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  19. Degnan AJ, Levy LM (2011) Pseudotumor cerebri: brief review of clinical syndrome and imaging findings. AJNR Am J Neuroradiol 32:1986–1993

    Article  CAS  PubMed  Google Scholar 

  20. Higgins JN, Cousins C, Owler BK, Sarkies N, Pickard JD (2003) Idiopathic intracranial hypertension: 12 cases treated by venous sinus stenting. J Neurol Neurosurg Psychiatry 74:1662–1666

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  21. King JO, Mitchell PJ, Thomson KR, Tress BM (1995) Cerebral venography and manometry in idiopathic intracranial hypertension. Neurology 45:2224–2228

    Article  CAS  PubMed  Google Scholar 

  22. Farb RI, Vanek I, Scott JN, Mikulis DJ, Willinsky RA, Tomlinson G, terBrugge KG (2003) Idiopathic intracranial hypertension: the prevalence and morphology of sinovenous stenosis. Neurology 60:1418–1424

    Article  CAS  PubMed  Google Scholar 

  23. Sander K, Poppert H, Etgen T, Hemmer B, Sander D (2011) Dynamics of intracranial venous flow patterns in patients with idiopathic intracranial hypertension. Eur Neurol 66:334–338

    Article  CAS  PubMed  Google Scholar 

  24. Rohr A, Bindeballe J, Riedel C, van Baalen A, Bartsch T, Doerner L, Jansen O (2012) The entire dural sinus tree is compressed in patients with idiopathic intracranial hypertension: a longitudinal, volumetric magnetic resonance imaging study. Neuroradiology 54:25–33

    Article  PubMed  Google Scholar 

  25. Connor SE, Siddiqui MA, Stewart VR, O’Flynn EA (2008) The relationship of transverse sinus stenosis to bony groove dimensions provides an insight into the aetiology of idiopathic intracranial hypertension. Neuroradiology 50:999–1004

    Article  CAS  PubMed  Google Scholar 

  26. Ahmed RM, Wilkinson M, Parker GD, Thurtell MJ, Macdonald J, McCluskey PJ, Allan R, Dunne V, Hanlon M, Owler BK et al (2011) Transverse sinus stenting for idiopathic intracranial hypertension: a review of 52 patients and of model predictions. AJNR Am J Neuroradiol 32:1408–1414

    Article  CAS  PubMed  Google Scholar 

  27. Stienen A, Weinzierl M, Ludolph A, Tibussek D, Hausler M (2008) Obstruction of cerebral venous sinus secondary to idiopathic intracranial hypertension. Eur J Neurol 15:1416–1418

    Article  CAS  PubMed  Google Scholar 

  28. Tripathi BJ, Tripathi RC (1974) Vacuolar transcellular channels as a drainage pathway for cerebrospinal fluid. J Physiol 239:195–206

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  29. Gomez DG, Potts DG (1977) Effects of pressure on the arachnoid villus. Exp Eye Res 25(Suppl):117–125

    Article  PubMed  Google Scholar 

  30. Gupta S, Soellinger M, Grzybowski DM, Boesiger P, Biddiscombe J, Poulikakos D, Kurtcuoglu V (2010) Cerebrospinal fluid dynamics in the human cranial subarachnoid space: an overlooked mediator of cerebral disease. I. Computational model. J R Soc Interface 7:1195–1204

    Article  PubMed Central  PubMed  Google Scholar 

  31. Holman DW, Kurtcuoglu V, Grzybowski DM (2010) Cerebrospinal fluid dynamics in the human cranial subarachnoid space: an overlooked mediator of cerebral disease. II. In vitro arachnoid outflow model. J R Soc Interface 7:1205–1218

    Article  PubMed Central  PubMed  Google Scholar 

  32. Johnston M, Zakharov A, Papaiconomou C, Salmasi G, Armstrong D (2004) Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species. Cerebrospinal Fluid Res 1:2

    Article  PubMed Central  PubMed  Google Scholar 

  33. Koh L, Zakharov A, Johnston M (2005) Integration of the subarachnoid space and lymphatics: is it time to embrace a new concept of cerebrospinal fluid absorption? Cerebrospinal Fluid Res 2:6

    Article  PubMed Central  PubMed  Google Scholar 

  34. Yang Z, Wang B, Wang C, Liu P (2011) Primary spontaneous cerebrospinal fluid rhinorrhea: a symptom of idiopathic intracranial hypertension? J Neurosurg 115:165–170

    Article  PubMed  Google Scholar 

  35. Hinson SR, Pittock SJ, Lucchinetti CF, Roemer SF, Fryer JP, Kryzer TJ, Lennon VA (2007) Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica. Neurology 69:2221–2231

    Article  CAS  PubMed  Google Scholar 

  36. Dhungana S, Waters P, Ismail A, Woodroofe N, Vincent A, Sharrack B (2010) Absence of aquaporin-4 antibodies in patients with idiopathic intracranial hypertension. J Neurol 257:1211–1212

    Article  PubMed  Google Scholar 

  37. Kerty E, Heuser K, Indahl UG, Berg PR, Nakken S, Lien S, Omholt SW, Ottersen OP, Nagelhus EA (2013) Is the brain water channel aquaporin-4 a pathogenetic factor in idiopathic intracranial hypertension? Results from a combined clinical and genetic study in a Norwegian cohort. Acta Ophthalmol 91:88–91

    Article  CAS  PubMed  Google Scholar 

  38. Friedman DI (2012) Aquaporin-4 antibodies and idiopathic intracranial hypertension: the jury is in and the channels are out. Cephalalgia 32:183–184

    Article  PubMed  Google Scholar 

  39. Daniels AB, Liu GT, Volpe NJ, Galetta SL, Moster ML, Newman NJ, Biousse V, Lee AG, Wall M, Kardon R et al (2007) Profiles of obesity, weight gain, and quality of life in idiopathic intracranial hypertension (pseudotumor cerebri). Am J Ophthalmol 143:635–641

    Article  PubMed  Google Scholar 

  40. Hannerz J, Ericson K (2009) The relationship between idiopathic intracranial hypertension and obesity. Headache 49:178–184

    Article  PubMed  Google Scholar 

  41. Bauerle J, Nedelmann M (2011) Sonographic assessment of the optic nerve sheath in idiopathic intracranial hypertension. J Neurol 258:2014–2019

    Article  PubMed  Google Scholar 

  42. Sinclair AJ, Burdon MA, Nightingale PG, Ball AK, Good P, Matthews TD, Jacks A, Lawden M, Clarke CE, Stewart PM et al (2010) Low energy diet and intracranial pressure in women with idiopathic intracranial hypertension: prospective cohort study. BMJ 341:c2701

    Article  PubMed Central  PubMed  Google Scholar 

  43. Szewka AJ, Bruce BB, Newman NJ, Biousse V (2013) Idiopathic intracranial hypertension: relation between obesity and visual outcomes. J Neuroophthalmol 33:4–8

    Article  PubMed Central  PubMed  Google Scholar 

  44. Wozniak SE, Gee LL, Wachtel MS, Frezza EE (2009) Adipose tissue: the new endocrine organ? A review article. Dig Dis Sci 54:1847–1856

    Article  PubMed  Google Scholar 

  45. Britton C, Boxhill C, Brust JC, Healton EB, Braun CW, Killian P (1980) Pseudotumor cerebri, empty sella syndrome, and adrenal adenoma. Neurology 30:292–296

    Article  CAS  PubMed  Google Scholar 

  46. Newman PK, Snow M, Hudgson P (1980) Benign intracranial hypertension and Cushing’s disease. Br Med J 281:113

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  47. Glueck CJ, Aregawi D, Goldenberg N, Golnik KC, Sieve L, Wang P (2005) Idiopathic intracranial hypertension, polycystic-ovary syndrome, and thrombophilia. J Lab Clin Med 145:72–82

    Article  PubMed  Google Scholar 

  48. Kesler A, Kliper E, Shenkerman G, Stern N (2010) Idiopathic intracranial hypertension is associated with lower body adiposity. Ophthalmology 117:169–174

    Article  PubMed  Google Scholar 

  49. Rauz S, Cheung CM, Wood PJ, Coca-Prados M, Walker EA, Murray PI, Stewart PM (2003) Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 lowers intraocular pressure in patients with ocular hypertension. QJM 96:481–490

    Article  CAS  PubMed  Google Scholar 

  50. Sinclair AJ, Walker EA, Burdon MA, van Beek AP, Kema IP, Hughes BA, Murray PI, Nightingale PG, Stewart PM, Rauz S et al (2010) Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation? J Clin Endocrinol Metab 95:5348–5356

    Article  CAS  PubMed  Google Scholar 

  51. Sinclair AJ, Onyimba CU, Khosla P, Vijapurapu N, Tomlinson JW, Burdon MA, Stewart PM, Murray PI, Walker EA, Rauz S (2007) Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus. J Neuroendocrinol 19:614–620

    Article  CAS  PubMed  Google Scholar 

  52. Sinclair AJ, Ball AK, Burdon MA, Clarke CE, Stewart PM, Curnow SJ, Rauz S (2008) Exploring the pathogenesis of IIH: an inflammatory perspective. J Neuroimmunol 201–202:212–220

    Article  PubMed  Google Scholar 

  53. Dhungana S, Sharrack B, Woodroofe N (2009) IL-1beta, TNF and IP-10 in the cerebrospinal fluid and serum are not altered in patients with idiopathic intracranial hypertension compared to controls. Clin Endocrinol (Oxf) 71:896–897

    Article  Google Scholar 

  54. Ball AK, Sinclair AJ, Curnow SJ, Tomlinson JW, Burdon MA, Walker EA, Stewart PM, Nightingale PG, Clarke CE, Rauz S (2009) Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance? Clin Endocrinol (Oxf) 70:863–869

    Article  CAS  Google Scholar 

  55. Dhungana S, Sharrack B, Woodroofe N (2009) Cytokines and chemokines in idiopathic intracranial hypertension. Headache 49:282–285

    Article  PubMed  Google Scholar 

  56. Bader M, Peters J, Baltatu O, Muller DN, Luft FC, Ganten D (2001) Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research. J Mol Med (Berl) 79:76–102

    Article  CAS  Google Scholar 

  57. Barry DI, Jarden JO, Paulson OB, Graham DI, Strandgaard S (1984) Cerebrovascular aspects of converting-enzyme inhibition I: effects of intravenous captopril in spontaneously hypertensive and normotensive rats. J Hypertens 2:589–597

    Article  CAS  PubMed  Google Scholar 

  58. Arregui A, Iversen LL (1978) Angiotensin-converting enzyme: presence of high activity in choroid plexus of mammalian brain. Eur J Pharmacol 52:147–150

    Article  CAS  PubMed  Google Scholar 

  59. Brettschneider J, Hartmann N, Lehmensiek V, Mogel H, Ludolph AC, Tumani H (2011) Cerebrospinal fluid markers of idiopathic intracranial hypertension: is the renin-angiotensinogen system involved? Cephalalgia 31:116–121

    Article  PubMed  Google Scholar 

  60. Thurtell MJ, Trotti LM, Bixler EO, Rye DB, Bliwise DL, Newman NJ, Biousse V, Bruce BB (2013) Obstructive sleep apnea in idiopathic intracranial hypertension: comparison with matched population data. J Neurol 260:1748–1751

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  61. Thurtell MJ, Bruce BB, Rye DB, Newman NJ, Biousse V (2011) The Berlin questionnaire screens for obstructive sleep apnea in idiopathic intracranial hypertension. J Neuroophthalmol 31:316–319

    Article  PubMed  Google Scholar 

  62. Frisen L (1982) Swelling of the optic nerve head: a staging scheme. J Neurol Neurosurg Psychiatry 45:13–18

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  63. Sinclair AJ, Burdon MA, Nightingale PG, Matthews TD, Jacks A, Lawden M, Sivaguru A, Gaskin BJ, Rauz S, Clarke CE et al (2012) Rating papilloedema: an evaluation of the Frisen classification in idiopathic intracranial hypertension. J Neurol 259:1406–1412

    Article  PubMed  Google Scholar 

  64. Scott CJ, Kardon RH, Lee AG, Frisen L, Wall M (2010) Diagnosis and grading of papilledema in patients with raised intracranial pressure using optical coherence tomography vs clinical expert assessment using a clinical staging scale. Arch Ophthalmol 128:705–711

    Article  PubMed  Google Scholar 

  65. Echegaray S, Zamora G, Yu H, Luo W, Soliz P, Kardon R (2011) Automated analysis of optic nerve images for detection and staging of papilledema. Invest Ophthalmol Vis Sci 52:7470–7478

    Article  PubMed  Google Scholar 

  66. Lam BL, Morais CG Jr, Pasol J (2008) Drusen of the optic disc. Curr Neurol Neurosci Rep 8:404–408

    Article  PubMed  Google Scholar 

  67. Waisbourd M, Leibovitch I, Goldenberg D, Kesler A (2011) OCT assessment of morphological changes of the optic nerve head and macula in idiopathic intracranial hypertension. Clin Neurol Neurosurg 113:839–843

    Article  PubMed  Google Scholar 

  68. Skau M, Yri H, Sander B, Gerds TA, Milea D, Jensen R (2013) Diagnostic value of optical coherence tomography for intracranial pressure in idiopathic intracranial hypertension. Graefes Arch Clin Exp Ophthalmol 251:567–574

    Article  PubMed  Google Scholar 

  69. Skau M, Sander B, Milea D, Jensen R (2011) Disease activity in idiopathic intracranial hypertension: a 3-month follow-up study. J Neurol 258:277–283

    Article  PubMed  Google Scholar 

  70. Gu XZ, Tsai JC, Wurdeman A, Wall M, Foote T, Sadun AA (1995) Pattern of axonal loss in longstanding papilledema due to idiopathic intracranial hypertension. Curr Eye Res 14:173–180

    Article  CAS  PubMed  Google Scholar 

  71. Heidary G, Rizzo JF 3rd (2010) Use of optical coherence tomography to evaluate papilledema and pseudopapilledema. Semin Ophthalmol 25:198–205

    Article  PubMed  Google Scholar 

  72. Kaufhold F, Kadas EM, Schmidt C, Kunte H, Hoffmann J, Zimmermann H, Oberwahrenbrock T, Harms L, Polthier K, Brandt AU et al (2012) Optic nerve head quantification in idiopathic intracranial hypertension by spectral domain OCT. PLoS One 7:e36965

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  73. Kardon RH (2011) Role of the macular optical coherence tomography scan in neuro-ophthalmology. J Neuroophthalmol 31:353–361

    Article  PubMed Central  PubMed  Google Scholar 

  74. Kupersmith MJ, Sibony P, Mandel G, Durbin M, Kardon RH (2011) Optical coherence tomography of the swollen optic nerve head: deformation of the peripapillary retinal pigment epithelium layer in papilledema. Invest Ophthalmol Vis Sci 52:6558–6564

    Article  PubMed Central  PubMed  Google Scholar 

  75. Costa-Cunha LV, Cunha LP, Malta RF, Monteiro ML (2009) Comparison of Fourier-domain and time-domain optical coherence tomography in the detection of band atrophy of the optic nerve. Am J Ophthalmol 147(56–63):e52

    Google Scholar 

  76. Lueck C, McIlwaine G (2005). Interventions for idiopathic intracranial hypertension. Cochrane Database Syst Rev CD003434

  77. Ko MW, Chang SC, Ridha MA, Ney JJ, Ali TF, Friedman DI, Mejico LJ, Volpe NJ, Galetta SL, Balcer LJ et al (2011) Weight gain and recurrence in idiopathic intracranial hypertension: a case-control study. Neurology 76:1564–1567

    Article  CAS  PubMed  Google Scholar 

  78. Celebisoy N, Gokcay F, Sirin H, Akyurekli O (2007) Treatment of idiopathic intracranial hypertension: topiramate vs acetazolamide, an open-label study. Acta Neurol Scand 116:322–327

    Article  CAS  PubMed  Google Scholar 

  79. Ball AK, Howman A, Wheatley K, Burdon MA, Matthews T, Jacks AS, Lawden M, Sivaguru A, Furmston A, Howell S et al (2011) A randomised controlled trial of treatment for idiopathic intracranial hypertension. J Neurol 258:874–881

    Article  CAS  PubMed  Google Scholar 

  80. Deftereos SN, Panagopoulos G, Georgonikou D, Karageorgiou CE, Karageorgiou E, Piadites G (2011) Treatment of idiopathic intracranial hypertension: is there a place for octreotide? Cephalalgia 31:1679–1680

    Article  PubMed  Google Scholar 

  81. In http://clinicaltrials.gov/ct2/show/NCT01003639

  82. Alsuhaibani AH, Carter KD, Nerad JA, Lee AG (2011) Effect of optic nerve sheath fenestration on papilledema of the operated and the contralateral nonoperated eyes in idiopathic intracranial hypertension. Ophthalmology 118:412–414

    Article  PubMed  Google Scholar 

  83. Banta JT, Farris BK (2000) Pseudotumor cerebri and optic nerve sheath decompression. Ophthalmology 107:1907–1912

    Article  CAS  PubMed  Google Scholar 

  84. Plotnik JL, Kosmorsky GS (1993) Operative complications of optic nerve sheath decompression. Ophthalmology 100:683–690

    Article  CAS  PubMed  Google Scholar 

  85. Wilkes BN, Siatkowski RM (2009) Progressive optic neuropathy in idiopathic intracranial hypertension after optic nerve sheath fenestration. J Neuroophthalmol 29:281–283

    Article  PubMed  Google Scholar 

  86. Sinclair AJ, Kuruvath S, Sen D, Nightingale PG, Burdon MA, Flint G (2011) Is cerebrospinal fluid shunting in idiopathic intracranial hypertension worthwhile? A 10-year review. Cephalalgia 31:1627–1633

    Article  PubMed  Google Scholar 

  87. Rosenberg ML, Corbett JJ, Smith C, Goodwin J, Sergott R, Savino P, Schatz N (1993) Cerebrospinal fluid diversion procedures in pseudotumor cerebri. Neurology 43:1071–1072

    Article  CAS  PubMed  Google Scholar 

  88. Eggenberger ER, Miller NR, Vitale S (1996) Lumboperitoneal shunt for the treatment of pseudotumor cerebri. Neurology 46:1524–1530

    Article  CAS  PubMed  Google Scholar 

  89. El-Saadany WF, Farhoud A, Zidan I (2012) Lumboperitoneal shunt for idiopathic intracranial hypertension: patients’ selection and outcome. Neurosurg Rev 35:239–243 discussion 243–234

    Article  PubMed  Google Scholar 

  90. Kandasamy J, Hayhurst C, Clark S, Jenkinson MD, Byrne P, Karabatsou K, Mallucci CL (2011) Electromagnetic stereotactic ventriculoperitoneal csf shunting for idiopathic intracranial hypertension: a successful step forward? World Neurosurg 75:155–160 discussion 132–153

    Article  PubMed  Google Scholar 

  91. Abubaker K, Ali Z, Raza K, Bolger C, Rawluk D, O’Brien D (2011) Idiopathic intracranial hypertension: lumboperitoneal shunts versus ventriculoperitoneal shunts–case series and literature review. Br J Neurosurg 25:94–99

    Article  PubMed  Google Scholar 

  92. Tarnaris A, Toma AK, Watkins LD, Kitchen ND (2011) Is there a difference in outcomes of patients with idiopathic intracranial hypertension with the choice of cerebrospinal fluid diversion site: a single centre experience. Clin Neurol Neurosurg 113:477–479

    Article  PubMed  Google Scholar 

  93. Toma AK, Dherijha M, Kitchen ND, Watkins LD (2010) Use of lumboperitoneal shunts with the Strata NSC valve: a single-center experience. J Neurosurg 113:1304–1308

    Article  PubMed  Google Scholar 

  94. Ahmed R, Friedman DI, Halmagyi GM (2011) Stenting of the transverse sinuses in idiopathic intracranial hypertension. J Neuroophthalmol 31:374–380

    Article  PubMed  Google Scholar 

  95. Albuquerque FC, Dashti SR, Hu YC, Newman CB, Teleb M, McDougall CG, Rekate HL (2011) Intracranial venous sinus stenting for benign intracranial hypertension: clinical indications, technique, and preliminary results. World Neurosurg 75:648–652 discussion 592–645

    Article  PubMed  Google Scholar 

  96. Friedman DI (2006) Cerebral venous pressure, intra-abdominal pressure, and dural venous sinus stenting in idiopathic intracranial hypertension. J Neuroophthalmol 26:61–64

    Article  PubMed  Google Scholar 

  97. Fridley J, Foroozan R, Sherman V, Brandt ML, Yoshor D (2011) Bariatric surgery for the treatment of idiopathic intracranial hypertension. J Neurosurg 114:34–39

    Article  PubMed  Google Scholar 

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  1. Birmingham Neuro-ophthalmology Unit, University Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, UK

    Ruchika Batra

  2. Neurotrauma and Neurodegeneration, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The Medical School, The University of Birmingham, Wolfson Drive, Edgbaston, Birmingham, B15 2TT, UK

    Alexandra Sinclair

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Batra, R., Sinclair, A. Idiopathic intracranial hypertension; research progress and emerging themes. J Neurol 261, 451–460 (2014). https://doi.org/10.1007/s00415-013-7019-7

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