Log in

Malignant cervical teratoma: report of a case in a newborn

  • Head and Neck Oncology
  • Published:
European Archives of Oto-Rhino-Laryngology and Head & Neck Aims and scope Submit manuscript

Abstract

Malignant cervical teratoma (MCT) usually appears in newborns as an enlarging mass of the neck that causes respiratory distress, requiring prompt airway control. We report a case of MCT in an infant electively delivered at 32 weeks to prevent airway impairment. At first, the preoperative diagnosis was hygroma of the neck, and a surgical excision was performed when the newborn was 9 days old. Diagnosis was benign extragonadic immature teratoma, but it was changed in MCT when cervical metastases appeared and the alpha-fetoprotein (AFP) level increased. Subsequent surgical procedures and chemotherapy were necessary. The child has been free from disease and healthy for 7 years since the last surgery. The preoperative diagnosis of MCT is difficult because of its rarity and non-specific clinical findings. Surgical excision is required for an adequate cure and airway repair; a long-term follow-up is mandatory to promptly treat any recurrence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Selvadurai DK, Moir AA, James R (1997) Cervical teratoma. A case report and review of management. CME Bulletin. Otorhinolaryngology 1:37–38

    Google Scholar 

  2. April MM, Ward RF, Garelick JM (1998) Diagnosis, management and follow-up of congenital head and neck teratomas. Laryngoscope 108:1398–1401

    Google Scholar 

  3. Kerner B, Flaum E (1998) Cervical teratoma: prenatal diagnosis and long-term follow-up. Prenat Diagn 18:51

    Google Scholar 

  4. Cannon CR, Johns ME, Fechner RE (1987) Immature teratoma of the larynx. Otolaryngol Head Neck Surg 96:366–368

    Google Scholar 

  5. Dehner LP, Mills A, Talerman A (1990) Germ cell neoplasms of the head and neck soft tissues: a pathologic spectrum of teratomatous and endodermal sinus tumors. Hum Pathol 21:309–318

    Google Scholar 

  6. Sbragia L, Paek BW, Feldstein VA, Farrel JA, Harrison MR, Albanese CT, Farman DL (2001) Outcome of prenatally diagnosed solid fetal tumors. J Pediatr Surg 8:1244–1247

    Google Scholar 

  7. Batsakis JG (1979) Teratomas of the head and neck. In: Tumors of the head and neck, 2nd edn. Williams & Wilkin, Baltimore, pp 226–231

  8. Touran T, Applebaum H, Frost DB, Richardson R, Taber P, Rowland J (1989) Congenital metastatic cervical teratoma: diagnostic and management considerations. J Pediatr Surg 24:21–23

    Google Scholar 

  9. Green JS, Dickinson FL, Rickett A, Moir A (1998) MRI in the assessment of a newborn with cervical teratoma. Pediatr Radiol 28:709–710

    Google Scholar 

  10. Lalwani AK, Engel TL (1992) Teratoma of the tongue: a case report and review of the literature. Int J Pediatr Otorhinolaryngol 24:261–268

    Google Scholar 

  11. Mahour GH, Landing BH, Woolley MM (1978) Teratomas in children: clinicophatologic studies in 133 patients. Z Kinderchir 23:365–380

    Google Scholar 

  12. Tapper D, Lack EE (1983) Teratomas in infancy and childhood. Ann Surg 198:398–408

    Google Scholar 

  13. Wakhlu A, Wakhlu AK (2000) Head and neck teratomas in children. Pediatr Surg Int 16:333–337

    Google Scholar 

  14. Gonzalez-Crussi F (1982) Benign or malignant? A pratical approach. In: Extragonadal teratomas: atlas of tumor pathology, Sec. Series Fascicle 18. Armed Forces Institute of Pathology, Washington, DC, pp 44–49

  15. Carr MM, Thorner P, Phillips JH (1997) Congenital teratomas of the head and neck. J Otolaryngol 26:246–252

    Google Scholar 

  16. Jaarsma AS, Tamminga RY (1994) Neonatal teratoma presenting as Hygroma colli. Eur J Pediatr 153:276–278

    Google Scholar 

  17. Ward RF, April M (1989) Teratomas of the head and neck. Otolaryngol Clin North Am 22:621–629

    Google Scholar 

  18. Batsakis JG, El-Naggar AK, Hicks MJ (1993) Epithelial choristomas and teratomas of the tongue. Ann Otol Rhinol Laryngol 102:567–569

    Google Scholar 

  19. Uchiyama M (1995) A huge immature cervical teratoma in a newborn: report of a case. Surg Today 25:737–740

    Google Scholar 

  20. Altman RP, Randolph JG, Lilly JR (1974) Sacrococcygeal teratoma. American Academy of Pediatrics surgical section survey 1973. J Pediatr Surg 9:398–398

    Google Scholar 

  21. Antoine FA, White JD Jr, Heffner DK, Case C (1985) Teratoma of the tongue: a case report and literature review. Laryngoscope 95:1262–1263

    Google Scholar 

  22. Holinger LD, Birnholz JC (1987) Management of infants with prenatal ultrasound diagnosis of airway obstruction by teratoma. Ann Otol Rhinol Laryngol 96:61–64

    Google Scholar 

  23. Teal LN, Angtuago TL, Jimenez JF (1988) Fetal teratomas; antenatal diagnosis and clinical management. J Clin Ultrasound 16:329–336

    Google Scholar 

  24. Sharma AK, Sharma CS, Gupta AK, Sarin YK, Agarwal LD, Zaffar M (1993) Teratomas in pediatric age group: experience with 75 cases. Indian Pediatr 30:689–694

    Google Scholar 

  25. Uchida K, Urata H, Suzuki H (1998) Teratoma of the tongue in neonates: report of a case and review of the literature. Pediatr Surg Int 14:79–81

    Google Scholar 

  26. Hirose S, Sydorak RM, Tsao K, Cauldwell CB, Newman KD, Mychaliska GB, Albanese CT, Lee H, Farmer DL (2003) Spectrum of intrapartum management strategies for giant fetal cervical teratoma. J Pediatr Surg 38:446–450

    Google Scholar 

  27. Sichel JY, Eliashar R, Yatsiv I, Moshe Gomori J, Nadjari M, Springer C, Ezra Y (2002) A multidisciplinary team approach for management of a giant congenital cervical teratoma. Int J Pediatr Otorhinolaryngol 65:241–247

    Google Scholar 

  28. Gundry SR, Wesley JR, Klein MD (1983) Cervical teratomas in the newborn. J Paed Surg 18:382–386

    Google Scholar 

  29. Sherer DM, Woods JR (1993) Prenatal sonographic assessment of early, rapidly growing fetal cervical teratoma. Prenat Diagn 13:1079–1084

    Google Scholar 

  30. Shah SI, Holterman A, Licameli GR (2001) Congenital cervical teratoma: airway management and complications. Otolaryngol Head Neck Surg 124:53–55

    Google Scholar 

  31. Tjalma WA (2003) The value of AFP in congenital cervical teratoma. J Pediatr Surg 38:1846

    Google Scholar 

  32. Myers LB, Bulich LA, Mizrahi A, Barnewolt C, Estroff J, Benson C, Kim HB, Jennings R (2003) Ultrasonographic guidance for location of the trachea during the EXIT procedure for cervical teratoma. J Pediatr Surg 38:E12

    Google Scholar 

  33. Farman DL (2001) Outcome of prenatally diagnosed solid fetal tumors. J Pediatr Surg 8:1244–1247

    Google Scholar 

  34. Zuzuarregui M, Ugalde FJ (1984) Prenatal ultrasound diagnosis of fetal teratomas of the neck. J Clin Ultrasound 12:509–511

    Google Scholar 

  35. Berge SJ, von Lindern JJ, Appel T, Braumann B, Niederhagen B (2004) Diagnosis and management of cervical teratomas. Br J Oral Maxillofac Surg 42:41–45

    Google Scholar 

  36. Grosfeld JL, Ballantine TVN, Lowe D (1976) Benign and malignant teratomas in children: analysis of 85 patients. Surgery 80:297–305

    Google Scholar 

  37. Rothschild MA, Catalano P, Urken M (1994) Evaluation and management of congenital cervical teratoma. Arch Otolaryngol Head Neck Surg 120:444–448

    Google Scholar 

  38. Wiatrak BJ, Meyer CM, Bratcher GO (1990) Report of a nasopharyngeal teratoma evaluated with magnetic resonance imaging. Head Neck Surg 102:186–190

    Google Scholar 

  39. Calaminus G, Schneider DT, Bokkerink JP, Gadner H, Harms D, Willers R, Gobel U (2003) Prognostic value of tumor size, metastases, extension into bone, and increased tumor marker in children with malignant sacrococcygeal germ cell tumors: a prospective evaluation of 71 patients treated in the German cooperative protocols Maligne Keimzelltumoren (MAKEI) 83/86 and MAKEI 89. J Clin Oncol 21:781–786

    Google Scholar 

  40. Smart PJ, Schwartz C, Kelsey A (1990) Ultrasonographic and biochemical abnormalities associated with the prenatal diagnosis of epignathus. Prenat Diagn 10:327–332

    Google Scholar 

  41. Pearl RM, Wisnicki J, Sinclair G (1984) Metastatic cervical teratoma of infancy. Plast Reconstr Surg 77:469–473

    Google Scholar 

  42. Batsakis JG (1984) Nomenclature of developmental tumors. Ann Otol Rhinol Laryngol 93:98–99

    Google Scholar 

  43. Baumann FR, Nerlich A (1993) Metastasizing cervical teratoma of the fetus. Pediatr Pathol 13:21–27

    Google Scholar 

  44. Batsakis JG, El-Naggar AK, Luna MA (1995) Teratomas of the head and neck with emphasis on malignancy. Ann Otol Rhinol Laryngol 104:496–500

    Google Scholar 

  45. Jourdan RB, Gauderer MWL (1988) Cervical teratomas: an analysis. Literature review and proposed classification. J Paed Surg 23:583–591

    Google Scholar 

  46. Watanatittan S, Othersen HB, Hughson MD (1981) Cervical teratoma in children. Prog Pediatr Surg 14:225–239

    Google Scholar 

  47. Azizkhan RG, Haase GM, Applebaum H (1995) Diagnosis, management and outcome of cervicofacial teratomas in neonates: A Children’s Cancer Group Study. J Paed Surg 30:312–316

    Google Scholar 

  48. Obajimi MO, Ogunseyinde AO, Omigbodun A, Adeyemo A, Olayemi O, Akang EE (2002) Neonatal teratoma of the neck causing respiratory distress: a case report. Niger Postgrad Med J 9:102–104

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marco Giudice.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Muscatello, L., Giudice, M. & Feltri, M. Malignant cervical teratoma: report of a case in a newborn. Eur Arch Otorhinolaryngol 262, 899–904 (2005). https://doi.org/10.1007/s00405-005-0917-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-005-0917-2

Keywords

Navigation