Abstract
We report a male with a coronary bifurcation lesion in the mid circumflex artery (CX). After predilatation, the lesion was treated with two drug-coated balloons (DCB). Primary success in the posterolateral branch was good; however the CX lesion had a residual stenosis including a non-flow-limiting type A dissection. After 6 months, angiography showed slight lumen enlargement in both branches of the bifurcation. Intravascular ultrasound identified about 35 % atherosclerotic plaque load within the inner area of the bifurcation but more than 50 % concentric atherosclerotic plaque burden in the vessel areas proximal and distal to the DCB-treated area.
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs00392-013-0556-3/MediaObjects/392_2013_556_Fig1_HTML.jpg)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs00392-013-0556-3/MediaObjects/392_2013_556_Fig2_HTML.jpg)
Similar content being viewed by others
References
Sigwart U, Puel J, Mirkovitch V, Joffre F, Kappenberger L (1987) Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty. New Engl J Med 316:701–706
Morice MC, Serruys PW, Sousa JE et al (2002) A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. New Engl J Med 346:1773–1780
Joner M, Finn AV, Farb A et al (2006) Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 48:193–202
Nakazawa G, Vorpahl M, Finn AV, Narula J, Virmani R (2009) One step forward and two steps back with drug-eluting-stents: from preventing restenosis to causing late thrombosis and nouveau atherosclerosis. JACC Cardiovasc Imaging 2:625–628
Scheller B, Hehrlein C, Bocksch W et al (2006) Treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter. New Engl J Med 355:2113–2124
Tepe G, Zeller T, Albrecht T et al (2008) Local delivery of paclitaxel to inhibit restenosis during angioplasty of the leg. New Engl J Med 358:689–699
Scheller B, Clever YP, Kelsch B et al (2012) Long-term follow-up after treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter. JACC Cardiovasc Interv 5:323–330
Unverdorben M, Vallbracht C, Cremers B et al (2009) Paclitaxel-coated balloon catheter versus paclitaxel-coated stent for the treatment of coronary in-stent restenosis. Circulation 119:2986–2994
Unverdorben M, Kleber FX, Heuer H et al (2010) Treatment of small coronary arteries with a paclitaxel-coated balloon catheter. Clin Res Cardiol 99:165–174
Wohrle J, Birkemeyer R, Markovic S et al (2011) Prospective randomised trial evaluating a paclitaxel-coated balloon in patients treated with endothelial progenitor cell capturing stents for de novo coronary artery disease. Heart 97:1338–1342
Rosli R, Zambahari R et al (2011) Paclitaxel-eluting balloon angioplasty and cobalt-chromium stents versus conventional angioplasty and paclitaxel-eluting stents in the treatment of native coronary artery stenoses in patients with diabetes mellitus. EuroInterv J EuroPCR Collab Work Group Interv Cardiol Eur Soc Cardiol 7:K83–K91
Habara S, Mitsudo K, Kadota K et al (2011) Effectiveness of paclitaxel-eluting balloon catheter in patients with sirolimus-eluting stent restenosis. JACC Cardiovasc Interv 4:149–154
Rittger H, Brachmann J, Sinha AM, et al (2012) A randomized, multicenter, single-blinded trial comparing paclitaxel-coated balloon angioplasty with plain balloon angioplasty in drug-eluting stent restenosis: the PEPCAD-DES study. J Am Coll Cardiol 59(15):1377–1382
Wohrle J, Zadura M, Mobius-Winkler S et al (2012) SeQuent Please World Wide Registry: clinical results of SeQuent please paclitaxel-coated balloon angioplasty in a large-scale, prospective registry study. J Am Coll Cardiol 60:1733–1738
Kleber FX, Mathey DG, Rittger H, Scheller B (2011) How to use the drug-eluting balloon: recommendations by the German consensus group. EuroIntervention 7(Suppl K):K125–K128
Werk M, Albrecht T, Meyer DR et al (2012) Paclitaxel-coated balloons reduce restenosis after femoro-popliteal angioplasty: evidence from the randomized PACIFIER trial. Circ Cardiovasc Interv 5:831–840
Gruntzig A (1978) Transluminal dilatation of coronary-artery stenosis. Lancet 1:263
Serruys PW, Onuma Y, Dudek D et al (2011) Evaluation of the second generation of a bioresorbable everolimus-eluting vascular scaffold for the treatment of de novo coronary artery stenosis: 12-month clinical and imaging outcomes. J Am Coll Cardiol 58:1578–1588
Diletti R, Farooq V, Girasis C et al (2013) Clinical and intravascular imaging outcomes at 1 and 2 years after implantation of absorb everolimus eluting bioresorbable vascular scaffolds in small vessels. Late lumen enlargement: does bioresorption matter with small vessel size? Insight from the ABSORB cohort B trial. Heart 99:98–105
Conflict of interest
Bruno Scheller has received lecture fees from B.Braun and Medtronic, travel support from Medtronic and B.Braun; he was named on a patent application of Charite university hospital, Berlin and is a shareholder of InnoRa GmbH, Berlin. Dieter Fischer has received lecture fees from B.Braun. Franz X. Kleber has received lecture fees and study grants from B.Braun. Ulrich Speck was named on a patent application of Charite university hospital, Berlin and is a shareholder of InnoRa GmbH, Berlin. Bodo Cremers has received lecture fees from B.Braun.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Scheller, B., Fischer, D., Clever, Y.P. et al. Treatment of a coronary bifurcation lesion with drug-coated balloons: lumen enlargement and plaque modification after 6 months. Clin Res Cardiol 102, 469–472 (2013). https://doi.org/10.1007/s00392-013-0556-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00392-013-0556-3