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Surgical management and outcomes of 12 cases of Wilms tumour with intracardiac extension from a single centre

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Abstract

Purpose

To review demographics, effect of preoperative chemotherapy on tumour thrombus, imaging, operative strategy, and outcomes of 12 patients presenting with intracardiac extension of Wilms tumour thrombus.

Methods

A retrospective audit was undertaken on patients with intracardiac extension of Wilms tumour. Patients were identified from the oncology database and information obtained on clinical presentation, stage, preoperative treatment, surgical procedures and complications, histology, and survival status. Ethics approval was obtained from the University of Cape Town Human Research Ethics Committee.

Results

From 1984 to 2016, 337 children with Wilms tumour were treated. Twelve (3.6%) had intracardiac extension of tumour thrombus, nine into the right atrium, and three into the right ventricle. Ultrasound, computerized tomography, magnetic resonance imaging, and echocardiograms were used to assess thrombus level. Patients were staged as stage III(8) and IV(4). All patients received preoperative chemotherapy. Thrombus retracted from the heart in two cases. One patient died preoperatively. Eleven underwent laparotomy, median sternotomy, and cardiopulmonary bypass (CPB). Four underwent cavectomy. Five required cavoatrial patches. Thrombus extending into the hepatic veins was extracted in five patients. There was one intraoperative complication and one perioperative death. Thrombus histology showed viable tumour in 9 of 11 patients. Three patients died of progressive disease. Seven patients are currently disease free.

Conclusion

A combination of imaging is required to determine thrombus extent, and this facilitates surgical planning. Preoperative chemotherapy may cause thrombus regression, thus avoiding CPB. CPB offers appropriate conditions for safe tumour thrombus excision. Full management in centres with appropriately experienced staff and facilities for CPB is recommended.

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Authors and Affiliations

  1. Divisions of Paediatric Surgery, Cardiothoracic Surgery, Anaesthetics and Haematology/Oncology, University of Cape Town, Red Cross War Memorial Children’s Hospital, Klipfontein Road, Rondebosch, Cape Town, 7700, South Africa

    Sharon G. Cox, A. Davidson, J. Thomas, A. Brooks, J. Hewitson, A. Numanoglu & A. J. W. Millar

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  1. Sharon G. Cox
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  2. A. Davidson
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  3. J. Thomas
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  4. A. Brooks
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  5. J. Hewitson
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  6. A. Numanoglu
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  7. A. J. W. Millar
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Correspondence to Sharon G. Cox.

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Cox, S.G., Davidson, A., Thomas, J. et al. Surgical management and outcomes of 12 cases of Wilms tumour with intracardiac extension from a single centre. Pediatr Surg Int 34, 227–235 (2018). https://doi.org/10.1007/s00383-017-4197-x

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