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Glaskörpermetastase eines malignen Melanoms der Haut unter Ipilimumab

Vitreous metastasis of malignant cutaneous melanoma during treatment with ipilimumab

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Zusammenfassung

Eine isolierte Glaskörpermetastase eines malignen Melanoms der Haut ohne Beteiligung der Aderhaut stellt einen äußerst seltenen Befund dar. Wir berichten über den Fall einer 59-jährigen Patientin, die eine solche Pathologie unter der Therapie mit dem Anti-CTLA-4-Antikörper Ipilimumab erlitt. Diese Kasuistik verdeutlicht die diagnostischen Schwierigkeiten eines derartigen Befundes und dass unter systemischer Immuntherapie ein Risiko für Metastasierung in immunprivilegierte Körperregionen besteht.

Abstract

An isolated metastasis of the vitreous body from a malignant cutaneous melanoma without involvement of the choroid is an extremely rare occurrence. We report on the case of a 59-year-old female patient who presented with a vitreous body metastasis during systemic treatment with the anti-cytotoxic T lymphocyte-associated antigen (anti-CTLA 4) antibody ipilimumab. This case report underlines the diagnostic difficulties in such cases and points out the risk of metastasis in immune-privileged sites under systemic immunotherapy.

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Literatur

  1. Manusow JS, Khoja L, Pesin N, Joshua AM, Mandelcorn ED (2014) Retinal vasculitis and ocular vitreous metastasis following complete response to PD-1 inhibition in a patient with metastatic cutaneous melanoma. J Immunother Cancer 2:41

    Article  PubMed  PubMed Central  Google Scholar 

  2. Jaissle GB, Szurman P, Rohrbach JM, Gelisken F, Bartz-Schmidt KU (2007) A case of cutaneous melanoma metastatic to the vitreous cavity: possible pathomechanism and review of literature. Graefes Arch Clin Exp Ophthalmol 245:733–740

    Article  PubMed  Google Scholar 

  3. Grajewski RS, Schuler-Thurner B, Mauch C, Kreuzberg N, Koch KR, Bergua A, Cursiefen C, Haindl LM (2014) Ocular diseases in metastatic cutaneous melanoma: review of 108 cesecutive patients in two German tertiary centers. Graefes Arch Clin Exp Ophthalmol 252:679–685

    Article  PubMed  Google Scholar 

  4. Niezgoda A, Niezgoda P, Czajkowski R (2015) Noval Approaches to Treatment of Advanced Melanoma: A Review on Targeted Therapy and Immunotherapy. Biomed Res Int 2015:851387

    Article  PubMed  PubMed Central  Google Scholar 

  5. Rosenberg C, Finger PT (2008) Cutaneous malignant melanoma metastatic to the eye, lids and orbit. Surv Ophthalmol 53:187–202

    Article  PubMed  Google Scholar 

  6. Gündüz K, Shields JA, Shields CL, Eagle RC Jr (1998) Cutaneous Melanoma Metastatic to the Vitreous Cavity. Ophthalmology 105(4):600–605

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Klinikum rechts der Isar, Augenklinik der TU München, 81675, München, Deutschland

    N. Kellermann, M. Maier & N. Feucht

Authors
  1. N. Kellermann
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  2. M. Maier
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  3. N. Feucht
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Correspondence to N. Kellermann.

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Interessenkonflikt

N. Kellermann, M. Maier und N. Feucht geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren. Alle Patienten, die über Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts zu identifizieren sind, haben hierzu ihre schriftliche Einwilligung gegeben.

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Kellermann, N., Maier, M. & Feucht, N. Glaskörpermetastase eines malignen Melanoms der Haut unter Ipilimumab. Ophthalmologe 114, 163–166 (2017). https://doi.org/10.1007/s00347-016-0271-3

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  • DOI: https://doi.org/10.1007/s00347-016-0271-3

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