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A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population

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Abstract

Primary osteoarthritis (OA) is a multifactorial disease with several genetics factors involved. The COL2A1 gene is of particular interest because it encodes for the most abundant protein in articular cartilage. The aim was to evaluate the association of COL2A1 gene polymorphism with OA of the knee in Mexican Mestizo patients. A case–control study was conducted; cases comprised patients with a radiologic scoring ≥2 and controls with a radiologic scoring <2. DNA was extracted from a peripheral blood sample, the polymorphic site of the COL2A1 gene was submitted to polymerase chain reaction (PCR), and the products were digested using PvuII restriction enzyme. For statistical analysis, a non-conditional logistic regression was developed. There were no associations among alleles in the overall sample, nevertheless, a significant association was found with p (Pp/pp) allele and OA of the knee grade 4 [odds ratio (OR), 95% confidence interval (CI 95%) 4.1 (1.2–14.6)] adjusted by gender, age, and body mass index (BMI). These results suggest an association of a COL2A1 gene polymorphism with advanced stages of OA of the knee in Mexican Mestizo population.

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Acknowledgments

This work was supported by a grant from the Consejo Nacional de Ciencia y Tecnología (CONACyT), México.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Servicio de Genética, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, Deleg. Tlalpan, 14889, México, D.F., Mexico

    Arturo Gálvez-Rosas, Celia González-Huerta, Verónica Marusa Borgonio-Cuadra & Antonio Miranda-Duarte

  2. Reumatología, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, Deleg. Tlalpan, 14889, México, D.F., Mexico

    Carolina Duarte-Salazár

  3. Rehabilitación Articular, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, Deleg. Tlalpan, 14889, México, D.F., Mexico

    Lorena Lara-Alvarado & María de los Ángeles Soria-Bastida

  4. Resonancia Magnética, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, Deleg. Tlalpan, 14889, México, D.F., Mexico

    Socorro Cortés-González

  5. Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (IPN), Prolongación de Carpio y Plan de Ayala s/n, Col. Santo Tomás, Deleg. Miguel Hidalgo, 11340, México, D.F., Mexico

    Arturo Gálvez-Rosas & Eva Ramón-Gallegos

Authors
  1. Arturo Gálvez-Rosas
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  2. Celia González-Huerta
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  3. Verónica Marusa Borgonio-Cuadra
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  4. Carolina Duarte-Salazár
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  5. Lorena Lara-Alvarado
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  6. María de los Ángeles Soria-Bastida
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  7. Socorro Cortés-González
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  8. Eva Ramón-Gallegos
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  9. Antonio Miranda-Duarte
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Correspondence to Antonio Miranda-Duarte.

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Gálvez-Rosas, A., González-Huerta, C., Borgonio-Cuadra, V.M. et al. A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population. Rheumatol Int 30, 1035–1039 (2010). https://doi.org/10.1007/s00296-009-1091-4

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  • DOI: https://doi.org/10.1007/s00296-009-1091-4

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