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Synthesis and encapsulation of magnetite nanoparticles in PLGA: effect of amount of PLGA on characteristics of encapsulated nanoparticles

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Abstract

Oleic acid-coated superparamagnetic iron oxide nanoparticles (Fe3O4) encapsulated within poly(d,l-lactide-co-glycolide) (PLGA) particles were prepared by the w/o/w emulsion technique using poly(vinyl alcohol) as a dispersant. The concentration of PLGA in the oil phase was varied (5, 15, 30, 45, and 60 mg/ml) at constant magnetite concentration in the oil phase (5 mg/ml) to study the properties of composite Fe3O4–PLGA nanoparticles. Even though PLGA concentration varied widely in the oil phase, the weight percent of 7–16 nm diameter magnetite in the particles varied only from 56 to 62 % (23–28 vol.%). The obtained composite nanoparticles were essentially spherical with magnetite spatially uniformly dispersed in individual PLGA particles, as measured by transmission electron microscopy (TEM). Also, the magnetite concentration in each particle did not vary widely as determined qualitatively via microscopy. Hydrodynamic diameters of the composite nanoparticles as measured by dynamic light scattering increased by approximately 10 % with added magnetite, with a smaller relative increase in diameter measured by TEM. The zeta potential of the particles was about −26 mV, independent of Fe3O4 loading. Relatively high saturation magnetizations (36–45 emu/g) were measured for these highly loaded particles, with the latter value only 7 emu/g lower than the value measured for the oleic acid-coated particles alone.

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Acknowledgments

This study was funded by National Center of Excellent for Petroleum, Petrochemicals, and Advance Materials, Chulalongkorn University. BPG contributed to this study partly supported by the National Institutes of Health (Grant no. R21-00357540) and the Oklahoma Center for the Advancement of Science and Technology (Grant no. AR082-009).

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Authors and Affiliations

  1. The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok, Thailand

    Kittima Bootdee & Manit Nithitanakul

  2. University of Oklahoma School of Chemical, Biological and Materials Engineering, Norman, OK, USA

    Brian P. Grady

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  1. Kittima Bootdee
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  2. Manit Nithitanakul
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Correspondence to Manit Nithitanakul.

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Bootdee, K., Nithitanakul, M. & Grady, B.P. Synthesis and encapsulation of magnetite nanoparticles in PLGA: effect of amount of PLGA on characteristics of encapsulated nanoparticles. Polym. Bull. 69, 795–806 (2012). https://doi.org/10.1007/s00289-012-0773-3

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  • DOI: https://doi.org/10.1007/s00289-012-0773-3

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