SpringerLink
Log in

Preparation and analysis of a sustained drug delivery system by PLGA–PEG–PLGA triblock copolymers

  • Original Paper
  • Published:
Polymer Bulletin Aims and scope Submit manuscript

Abstract

Traditional drug delivery systems that are based on multiple dosing are usually accompanied by many shortcomings, including unwanted fluctuations in the plasma concentration of the drug and poor patient compliance. In this study, we aimed to synthesize a polymeric drug delivery system based on a triblock copolymer of PLGA–PEG1000–PLGA and investigate its application as a controlled drug delivery system. Naltrexone hydrochloride and vitamin B12 were used as model drugs here. The copolymer was successfully synthesized by the ring-opening method. A phase transition analysis indicated that the copolymer is in gel at body temperature. The release profiles from the formulations showed a higher initial release followed by a slower pattern for up to 4 weeks. More than 50 % of the vitamin B12 and 60 % of the naltrexone hydrochloride were released during this period.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Hatefi A, Amsden B (2002) Biodegradable injectable in situ forming drug delivery systems. J Controlled Release 80(1–3):9–28

    Article  CAS  Google Scholar 

  2. Packhaeuser CB, Schnieders J, Oster CG, Kissel T (2004) In situ forming parenteral drug delivery systems: an overview. Eur J Pharm Biopharm 58(2):445–455

    Article  CAS  Google Scholar 

  3. Ruel-Gariépy E, Leroux J-C (2004) In situ-forming hydrogels—review of temperature-sensitive systems. Eur J Pharm Biopharm 58(2):409–426

    Article  Google Scholar 

  4. Jeong B, Kim SW, Bae YH (2002) Thermosensitive sol–gel reversible hydrogels. Adv Drug Deliv Rev 54(1):37–51

    Article  CAS  Google Scholar 

  5. Khodaverdi E, Rajabi O, Abdekhodai MJ, Wu XY (2008) Heterogenous composite membranes as pH responsive drug delivery systems. IJBMS 11(2):70–79

    Google Scholar 

  6. Zentner GM, Rathi R, Shih C, McRea JC, Seo M-H, Oh H, Rhee BG, Mestecky J, Moldoveanu Z, Morgan M, Weitman S (2001) Biodegradable block copolymers for delivery of proteins and water-insoluble drugs. J Controlled Release 72(1–3):203–215

    Article  CAS  Google Scholar 

  7. Qiao M, Chen D, Ma X, Liu Y (2005) Injectable biodegradable temperature-responsive PLGA–PEG–PLGA copolymers: synthesis and effect of copolymer composition on the drug release from the copolymer-based hydrogels. Int J Pharm 294(1–2):103–112

    Article  CAS  Google Scholar 

  8. Chen S, Singh J (2008) Controlled release of growth hormone from thermosensitive triblock copolymer systems: in vitro and in vivo evaluation. Int J Pharm 352(1-2):58–65

    Article  CAS  Google Scholar 

  9. Chen Singh (2005) Controlled delivery of testosterone from smart polymer solution based systems: invitro evaluation. Int J Pharm 295:183–190

    Article  CAS  Google Scholar 

  10. Kwon YM, Kim SW (2003) New biodegradable polymers for delivery of bioactive agent. Macromol Symp 207:179–186

    Article  Google Scholar 

  11. Ghahremankhani AA, Dorkoosh F, Dinarvand R (2007) PLGA–PEG–PLGA tri-block copolymers as an in situ gel forming system for calcitonin delivery. Polym Bull 59:637–646

    Article  CAS  Google Scholar 

  12. Moffatt S, Cristiano RJ (2006) PEGylated J591 mAb loaded in PLGA–PEG–PLGA tri-block copolymer for targeted delivery: in vitro evaluation in human prostate cancer cells. Int J Pharm 317(1):10–13

    Article  CAS  Google Scholar 

  13. Song Z, Feng R, Sun M, Guo C, Gao Y, Li L, Zhai G (2011) Curcumin-loaded PLGA–PEG–PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo. J Colloid Interface Sci 354:116–123

    Article  CAS  Google Scholar 

  14. Roth A, Hogan I, Farren C (1997) Naltrexone plus group therapy for the treatment of opiate-abusing health-care professionals. J Subst Abuse Treat 14(1):19–22

    Article  CAS  Google Scholar 

  15. Roozen HG, de Waart R, van der Windt DAWM, van den Brink W, de Jong CAJ, Kerkhof AJFM (2006) A systematic review of the effectiveness of naltrexone in the maintenance treatment of opioid and alcohol dependence. Eur Neuropsychopharmacol 16(5):311–323

    Article  CAS  Google Scholar 

  16. Caraballo I, Melgoza LM, Alvarez-Fuentes J, Soriano MC, Rabasco AM (1999) Design of controlled release inert matrices of naltrexone hydrochloride based on percolation concepts. Int J Pharm 181(1):23–30

    Article  CAS  Google Scholar 

  17. Dinarvand R, S HM, Sayar P, Alaee M, Atyabi F (2005) Preparation of a polymeric reservoir naltrexone delivery device: effect of PEG content of the PLA membrane on drug release. Therapy 2:407–413

    Article  CAS  Google Scholar 

  18. Salehi S, Nowruzi K, Entezami A, Asgharzadeh V, Davaran S (2009) Thermosensitive polylactide-glycolide delivery systems for treatment of narcotic addictions. Polym Adv Technol 20:416–422

    Article  CAS  Google Scholar 

  19. Ghahremankhani AA, Dorkoosh F (2008) PLGA–PEG–PLGA tri-block copolymers as in situ gel-forming peptide delivery system: effect of formulation properties on peptide release. Pharm Dev Technol 13:49–55

    Article  CAS  Google Scholar 

  20. Jeong B, Choi YK, Bae YH, Zentner G, Kim SW (1999) New biodegradable polymers for injectable drug delivery systems. J Controlled Release 62(1–2):109–114

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors are grateful for the financial support granted by Mashhad University of Medical Sciences and the Bo Ali Research Center Institute. The results described in this paper were part of a Pharm. D. student thesis proposal.

Author information

Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Elham Khodaverdi

  2. Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Farzin Hadizadeh, Farnaz Sadat Mirzazadeh Tekie & Afshin Jalali

  3. Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Elham Khodaverdi & Seyed Ahmad Mohajeri

  4. Biotechnology Group, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran

    Fariba Ganji

Authors
  1. Elham Khodaverdi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Farzin Hadizadeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Farnaz Sadat Mirzazadeh Tekie
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Afshin Jalali
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Seyed Ahmad Mohajeri
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Fariba Ganji
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Farzin Hadizadeh.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Khodaverdi, E., Hadizadeh, F., Tekie, F.S.M. et al. Preparation and analysis of a sustained drug delivery system by PLGA–PEG–PLGA triblock copolymers. Polym. Bull. 69, 429–438 (2012). https://doi.org/10.1007/s00289-012-0747-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00289-012-0747-5

Keywords

Search

Navigation