Abstract
Autogenous fat grafting is widely used for the correction of soft tissue contour deformity. However, the high absorption rate results in the need for overcorrection, and graft longevity is unpredictable. The authors hypothesized that epidermal growth factor (EGF), a potent stimulator of neovascularization, would improve fat graft survival. The experiment used two groups of New Zealand White Rabbit ear. Inguinal fat was harvested and injected with EGF or saline (n = 24, each group). The 48 cases of fat grafting were managed for observation of volume and morphologic change. The fat was harvested 3 months after the autogenous graft. The survival rate and the degree of neovascularization were measured. The grafts in the EGF group had a significantly higher survival rate than those in the control group. Histologic examination of the grafts demonstrated an increase in neovascularization and maintenance of fat cell morphology. These findings show that EGF can enhance fat graft survival and degree of neovascularization. Further well-controlled studies are required before EGF is used for clinical purposes.
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References
Neuber GA (1893) Fettransplantation. Verh Dtsch Ges CHir 22:66
Broeckaert TJ (1919) Contribution a L’etude des greffes adipeuses. Bull Acad R Med Belgique 28:440
Illouz YG (1986) The fat cell graft: a new technique to fill depressions. Plast Reconstr Surg 78:122
Founier PF (1990) Facial recontouring with fat grafting. Dermatol Clin 8:523
Sommer B, Sattler G (2000) Current concepts of fat graft survival: histology of aspirated adipose tissue and review of the literature. Dermatol Surg 26:1159
Monreal J (2003) Fat tissue as a permanent implant: new instruments and refinements. Aesthetic Surg J 23:213
Eremia S, Newman N (2000) Long-term follow-up after autologous fat grafting: analysis of results from 116 patients followed at least 12 months after receiving the last of a minimum of two treatments. Dermatol Surg 26:1150
Craft RO, Rophael J, Morrison WA, Vashi AV, Mitchell GM, Penington AJ (2009) Effect of local, long-term delivery of platelet-derived growth factor (PDGF) on injected fat graft survival in severe combined immunodeficient (SCID) mice. J Plast Reconstr Aesthet Surg 62:235
Atik B, Oztürk G, Erdoğan E, Tan O (2006) Comparison of techniques for long-term storage of fat grafts: an experimental study. Plast Reconstr Surg 118:1533
Blanton MW, Hadad I, Johnstone BH, Mund JA, Rogers PI, Eppley BL, March KL (2009) Adipose stromal cells and platelet-rich plasma therapies synergistically increase revascularization. Plast Reconstr Surg 123(2 Suppl):56s
Baek RM, Chung WJ, Lee YJ, Lee JH, Im TG, Yoon BH (2003) An experimental study on the wound-healing effects of recombinant human epidermal growth factors according to poloxamer concentrations in full-thickness excisional wound models of rats. J Korean Soc Plast Reconstr Surg 30:209
Viterbo F, Marques M, Valente M (1994) Fat-tissue injection versus graft: experimental study in rabbits. Ann Plast Surg 33:184
Peer LA (1956) The neglected free fat graft, its behavior and clinical use. Am J Surg 92(1):40–47
Coleman SR (2006) Structural fat grafting: more than a permanent filler. Plast Reconstr Surg 118:108
Chajchir A, Benzaquen I, Moretti E (1993, Spring) Comparative experimental study of autologous adipose tissue processed by different techniques. Aesthet Plast Surg 17(2):113–115
Kim SJ, Choi WI, Lee BI, Park SH, Park C, Koo SH (2007) The effect of platelet-rich plasma (PRP) on the survival of the autologous fat graft. J Korean Soc Plast Reconstr Surg 34:291
Locke MB, de Chalain TM (2008) Current practice in autologous fat transplantation: suggested clinical guidelines based on a review of recent literature. Ann Plast Surg 60:98
Por YC, Yeow VK, Louri N, Lim TK, Kee I, Song IC (2009) Platelet-rich plasma has no effect on increasing free fat graft survival in the nude mouse. J Plast Reconstr Aesthet Surg 62:1030
Park JS, Kim JY, Cho JY, Kang JS, Yu YH (2000) Epidermal growth factor (EGF) antagonizes transforming growth factor (TGF)-beta 1-induced collagen lattice contraction by human skin fibroblast. Biol Pharm Bull 23:1517
Gope R (2002) The effect of epidermal growth factor and platelet-derived growth factors on wound-healing process. Indian J Med Res 116:201
Babul A, Gonul B, DIncer S, Erdogan D, Ozogul C (2004) The effect of EGF application in gel form on histamine content of experimentally induced wound in mice. Amino Acids 27:321
Brown GL, Curtsinger LJ, White M, Mitchell RO, Pietsch J, Nordquist R, von Fraunhofer A, Schultz GS (1988) Acceleration of tensile strength of incisions treated with EGF and TGF-B. Ann Surg 208:788
Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M (2008) Growth factors and cytokines in wound healing. Wound Repair Regen 16:585
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Park, B., Kong, J.S., Kang, S. et al. The Effect of Epidermal Growth Factor on Autogenous Fat Graft. Aesth Plast Surg 35, 738–744 (2011). https://doi.org/10.1007/s00266-011-9679-y
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DOI: https://doi.org/10.1007/s00266-011-9679-y