Abstract
Postbiotics are a new class of health-promoting molecules that derive from probiotics. These new cosmetic and dermatological ingredients are defined as a ‘preparation of inanimate microorganisms and/or their components that confers a health benefit on the host’. This review focuses on what is presently known of these compounds, the benefits of using them, the main postbiotics products available in the market and players, the production key trends and available production methods. The main advantages identified for the use of postbiotics are related to their higher specificity of action on resident microbiota as of interaction with cells of the host compared to probiotics. Postbiotics can be produced/obtained especially through fermentative processes, but most of companies industrial processes are patented. Most of these compounds are usually derived from lactic acid bacteria, Lactobacillus genera and/or yeasts, especially Saccharomyces cerevisiae. Postbiotics go from metabolites like teichoic acids to polysaccharides among others and exhibit important biological properties such as antioxidant, anti-inflammatory, anti-proliferative and immunomodulatory—the reason why their use in cosmetic formulations must be considered. Besides that, when compared to probiotics, postbiotics have longer shelf life and greater safety and do not require viability in the topical formulation which turns them into an innovative approach within the cosmetic ingredients market. The main players are companies that operate in several areas, such as the chemical industry, food innovation, pharmaceutical and cosmetic industries, and the critical trends for production of these compounds include energy efficiency, emission-free mobility, conservation of finite resources and renewable raw material utilization.
Key points
• Postbiotics are mainly derived from lactic acid bacteria and S. cerevisiae.
• Postbiotics exhibit several biological properties.
• Postbiotics present several advantages over probiotics.
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References
Abbas HH, Mohammed S, Shawkat DS, Baker YM (2016) Effect of Lactobacillus sp. Crude bacteriocin (CB) and cell-free supernatant (CFS) against E. coli growth and adherence on vaginal epithelial cell surface. Int J Adv Res 4(1), 614–620. (ISSN 2320–5407)
Amaretti A, Di Nunzio M, Pompei A, Raimondi S, Rossi M, Bordoni A (2013) Antioxidant properties of potentially probiotic bacteria: in vitro and in vivo activities. Appl Microbiol Biotechnol 97(2):809–817. https://doi.org/10.1007/s00253-012-4241-7
Amiri S, Rezazadeh M, Alizadeh M, Rezaei R (2021a) Co-production of conjugated linoleic acids, exopolysaccharides and bacteriocins by Lactobacillus acidophilus LA5 and Bifidobacterium animalis subsp. lactis BB12 in supplemented dairy effluents. Chem Rev Lett 4: 66–76. https://doi.org/10.22034/crl.2021.253739.1086
Amiri S, Rezazadeh-Bari M, Alizadeh-Khaledabad M, Rezaei-Mokarram R, Sowti-Khiabani M (2021b) Fermentation optimization for co-production of postbiotics by Bifidobacterium lactis BB12 in cheese whey. Waste Biomass Valor 12(11):5869–5884. https://doi.org/10.1007/s12649-021-01429-7
Aguilar-Toalá JE, Garcia-Varela R, Garcia HS, Mata-Haro V, González-Córdova AF, Vallejo-Cordoba B, Hernández-Mendoza A (2018) Postbiotics: an evolving term within the functional foods field. Trends Food Sci Technol 75(June 2017):105–114. https://doi.org/10.1016/j.tifs.2018.03.009
Bio Component Research (n.d.) Bio-Hacked BCR™ the evolution of fermentation. https://www.bcringredients.com/bio-hacked-extracts/. Accessed 29 March 2021
Callewaert C, Knödlseder N, Karoglan A, Güell M, Paetzold B (2021) Skin microbiome transplantation and manipulation: current state of the art. Comput Struct Biotechnol J 19:624–631. https://doi.org/10.1016/j.csbj.2021.01.001
Ciardiello T, Pinto D, Marotta L, Giuliani G, Rinaldi F (2020) Effects of fermented oils on alpha-biodiversity and relative abundance of cheek resident skin microbiota. Cosmetics 7:34. https://doi.org/10.3390/COSMETICS7020034
Cicenia A, Santangelo F, Gambardella L, Pallotta L, Iebba V, Scirocco A, Marignani M, Tellan G, Carabotti M, Corazziari ES, Schippa S, Severi C (2016) Protective role of postbiotic mediators secreted by Lactobacillus rhamnosus GG versus lipopolysaccharide-induced damage in human colonic smooth muscle cells. J Clin Gastroenterol 50(December):S140–S144. https://doi.org/10.1097/MCG.0000000000000681
Clariant (2021) BifiDa, a new postbiotic for cosmetics. Postbiotics for a healthy skin. https://www.clariant.com/pt/Business-Units/Industrial-and-Consumer-Specialties/Personal-Care/Active-Ingredients/Postbiotics. Accessed 29 March 2021
Chemisches Laboratorium Dr. Kurt Richter GmbH (n.d.) Products. https://www.clr-berlin.com/products/. Accessed 29 March 2021
Codif (n.d.) EPS SEAPUR. Cutaneous blemishes | the answer already lies on your skin. http://www.codif-tn.com/en/principesactifs/eps-seapur/. Accessed 29 March 2021
Contipro (2019) InspiraSEA. Portfolio. https://www.contipro.com/portfolio/manufacturer-of-anti-ageing-cosmetic-raw-materials/inspirasea. Accessed 29 March 2021
Di Cagno R, Filannino P, Cantatore V, Gobbetti M (2019) Novel solid-state fermentation of bee-collected pollen emulating the natural fermentation process of bee bread. Food Microbiol 82:218–230. https://doi.org/10.1016/j.fm.2019.02.007
Dhillon GS, Kaur S, Brar SK (2013) Perspective of apple processing wastes as low-cost substrates for bioproduction of high value products: a review. Renew Sustain Energy Rev 27:789–805. https://doi.org/10.1016/j.rser.2013.06.046
DSM (2021) OXY 229 PF. Skin bioactives. https://www.dsm.com/personal-care/en_US/products/skin-bioactives/oxy-229-pf.html. Accessed 29 March 2021
Fournière M, Latire T, Souak D, Feuilloley MGJ, Bedoux G (2020) Staphylococcus epidermidis and Cutibacterium acnes: two major sentinels of skin microbiota and the influence of cosmetics. Microorganisms 8(11):1–31. https://doi.org/10.3390/microorganisms8111752
Freedman SB, Williamson-Urquhart S, Farion KJ, Gouin S, Willan AR, Poonai N, Hurley K, Sherman PM, Finkelstein Y, Lee BE, Pang XL, Chui L, Schnadower D, **e J, Gorelick M, Schuh S (2018) Multicenter trial of a combination probiotic for children with gastroenteritis. N Engl J Med 379(21):2015–2026. https://doi.org/10.1056/nejmoa1802597
GreenTech (n.d.) BIOTILYS. Phytobioactive Biotilys. https://www.greentech.fr/en/biotilys-2/. Accessed 29 March 2021
Guéniche A, Bastien P, Ovigne JM, Kermici M, Courchay G, Chevalier V, Breton L, Castiel-Higounenc I (2010) Bifidobacterium longum lysate, a new ingredient for reactive skin. Exp Dermatol 19(8):1–8. https://doi.org/10.1111/j.1600-0625.2009.00932.x
Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME (2014) Expert consensus document: the international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11(8):506–514. https://doi.org/10.1038/nrgastro.2014.66
Hoang BX, Shaw G, Pham P, Levine SA (2010) Lactobacillus rhamnosus cell lysate in the management of resistant childhood atopic eczema. Inflamm Allergy Drug Targets 9(3):192–196. https://doi.org/10.2174/187152810792231896
Innovacos (2017) BioptimizedTM Guava. Ingredients. http://innovacos.com/ingredients/active/bioptimized-guava/. Accessed 29 March 2021
Jensen GS, Benson KF, Carter SG, Endres JR (2010) GanedenBC30TM cell wall and metabolites: anti-inflammatory and immune modulating effects in vitro. BMC Immunol 11:15. https://doi.org/10.1186/1471-2172-11-15
Kalichem (n.d.) Kalibiome. Ingredients Catalogue. https://www.kalichem.it/ingredients/. Accessed 29 March 2021
Kang BS, Seo JG, Lee GS, Kim JH, Kim SY, Han YW, Kang H, Kim HO, Rhee JH, Chung MJ, Park YM (2009) Antimicrobial activity of enterocins from Enterococcus faecalis SL-5 against Propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effect. J Microbiol 47(1):101–109. https://doi.org/10.1007/s12275-008-0179-y
Karp SG, Igashiyama AH, Siqueira PF, Carvalho JC, Vandenberghe LPS, Thomaz-Soccol V, Coral J, Tholozan JL, Pandey A, Soccol CR (2011) Application of the biorefinery concept to produce l-lactic acid from the soybean vinasse at laboratory and pilot scale. Bioresour Technol 102(2):1765–1772. https://doi.org/10.1016/j.biortech.2010.08.102
Kim HS, Chae HS, Jeong SG, Ham JS, Im SK, Ahn CN, Lee JM (2006) In vitro antioxidative properties of lactobacilli. Asian-Australas J Anim Sci 19(2):262–265. https://doi.org/10.5713/ajas.2006.262
Kim HG, Lee SY, Kim NR, Lee HY, Ko MY, Jung BJ, Kim CM, Lee JM, Park JH, Han SH, Chung DK (2011) Lactobacillus plantarum lipoteichoic acid down-regulated Shigella flexneri peptidoglycan-induced inflammation. Mol Immunol 48(4):382–391. https://doi.org/10.1016/j.molimm.2010.07.011
Kimoto-Nira H, Aoki R, Sasaki K, Suzuki C, Mizumachi K (2012) Oral intake of heat-killed cells of Lactococcus lactis strain h61 promotes skin health in women. J Nutr Sci 1(4):1–7. https://doi.org/10.1017/jns.2012.22
Koirala S, Anal AK (2021) Probiotics-based foods and beverages as future foods and their overall safety and regulatory claims. Future Foods 3:100013. https://doi.org/10.1016/j.fufo.2021.100013
Koleilat A (2019) Beyond probiotics the postbiotics. Gastroenterol Hepatol: Open Access 10(6):324–326. https://doi.org/10.15406/ghoa.2019.10.00404
Kumar R, Sharma A, Gupta M, Padwad Y, Sharma R (2020) Cell-free culture supernatant of probiotic Lactobacillus fermentum protects against H2O2-induced premature senescence by suppressing ROS-Akt-mTOR axis in murine preadipocytes. Probiotics Antimicrob Proteins 12(2):563–576. https://doi.org/10.1007/s12602-019-09576-z
Kunk D (2019) Probiotics: elixir or empty promise. Lancet Gastroenterol Hepatol 4:81. https://doi.org/10.1016/S2468-1253(18)30415-1
LABIO (n.d.) BeBebiome. Products. http://www.labio.kr/bbs/board.php?bo_table=product. Accessed 29 March 2021
Lee MJ, Zang Z, Choi EY, Shin HK, Ji GE (2002) Cytoskeleton reorganization and cytokine production of macrophages by bifidobacterial cells and cell-free extracts. J Microbiol Biotechnol 12:398–405
Lee DE, Huh CS, Ra J, Choi ID, Jeong JW, Kim SH, Ryu JH, Seo YK, Koh JS, Lee JH, Sim JH, Ahn YT (2015) Clinical evidence of effects of Lactobacillus plantarum HY7714 on skin aging: a randomized, double blind, placebo-controlled study. J Microbiol Biotechnol 25(12):2160–2168. https://doi.org/10.4014/jmb.1509.09021
Lew LC, Liong MT (2013) Bioactives from probiotics for dermal health: functions and benefits. J Appl Microbiol 114(5):1241–1253. https://doi.org/10.1111/jam.12137
Mack DR (2005) Probiotics-mixed messages. Can Fam Physician 51(November):1455–1457
Majeed M, Majeed S, Nagabhushanam K, Mundkur L, Rajalakshmi HR, Shah K, Beede K (2020a) Novel topical application of a postbiotic, lactosporin®, in mild to moderate acne: a randomized, comparative clinical study to evaluate its efficacy, tolerability and safety. Cosmetics 7(3):1–15. https://doi.org/10.3390/COSMETICS7030070
Majeed M, Majeed S, Nagabhushanam K, Lawrence L, Arumugam S, Mundkur L (2020b) Skin protective activity of lactosporin-the extracellular metabolite from bacillus coagulans mtcc 5856. Cosmetics 7(4):1–14. https://doi.org/10.3390/cosmetics7040081
Marzani B, Pinto D, Minervini F, Calasso M, Di Cagno R, Giuliani G, Gobbetti M, De Angelis M (2012) The antimicrobial peptide pheromone Plantaricin A increases antioxidant defenses of human keratinocytes and modulates the expression of filaggrin, involucrin, β-defensin 2 and tumor necrosis factor-α genes. Exp Dermatol 21(9):665–671. https://doi.org/10.1111/j.1600-0625.2012.01538.x
Matsuguchi T, Takagi A, Matsuzaki T, Nagaoka M, Ishikawa K, Yokokura T, Yoshikai Y (2003) Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor alpha-inducing activities in macrophages through toll-like receptor 2. Clin Diagn Lab Immunol 10(2):259–266. https://doi.org/10.1128/CDLI.10.2.259-266.2003
Merghni A, Dallel I, Noumi E, Kadmi Y, Hentati H, Tobji S, Ben Amor A, Mastouri M (2017) Antioxidant and antiproliferative potential of biosurfactants isolated from Lactobacillus casei and their anti-biofilm effect in oral Staphylococcus aureus strains. Microb Pathog 104:84–89. https://doi.org/10.1016/j.micpath.2017.01.017
Ngoc LTN, Tran VV, Moon JY, Chae M, Park D, Lee YC (2019) Recent trends of sunscreen cosmetic: an update review. Cosmetics 6(4):64. https://doi.org/10.3390/cosmetics6040064
Onlystar Bio-Technology (n.d.) Product. https://onlystar.com/product.php. Accessed 29 March 2021
Ou CC, Ko JL, Lin MY (2006) Antioxidative effects of intracellular extracts of yogurt bacteria on lipid peroxidation and intestine 407 cells. J Food Drug Anal 14(3):304–310. https://doi.org/10.38212/2224-6614.2474
Phenbiox (n.d.) ACQUA DI RISO FERMENTATA. Technical Data Sheet. https://www.ulprospector.com/documents/1614982.pdf?bs=33934&b=3979240&st=1&r=eu&ind=personalcare. Accessed 12 August 2021
Phenbiox (n.d.) ALOFERM HF: boosted aloe through fermentation. Technical Data Sheet. https://www.ulprospector.com/documents/1604913.pdf?bs=33934&b=1637875&st=1&r=eu&ind=personalcare. Accessed 12 August 2021
Phenbiox (n.d.) LENTIMYRT HF: multilevel skin barrier function booster. Technical Data Sheet. https://www.ulprospector.com/documents/1592363.pdf?bs=33934&b=1313386&st=1&r=eu&ind=personalcare. Accessed 12 August 2021
Radiant (n.d.) PREBIOMETM. Product. http://en.eradiant.co.kr/product. Accessed 29 March 2021
Rinaldi F, Trink A, Pinto D (2020a) Efficacy of postbiotics in a PRP-like cosmetic product for the treatment of alopecia area Celsi: a randomized double-blinded parallel-group study. Dermatol Ther 10(3):483–493. https://doi.org/10.1007/s13555-020-00369-9
Rinaldi F, Pinto D, Giammaria G (2020b) Postbiotic evolution in dermatology. EC Microbiol 16(3):1–4
Rodrigues C, Vendenberghe LPS, Woiciechowski A, de Oliveira J, Letti LAJ, Soccol CR (2017) Production and application of lactic acid. In: Pandey A, Negi S, Soccol CR (eds) Current developments in biotechnology and bioengineering - production, isolation and purification of industrial products. Elsevier, pp 543–556
Sabinsa (2021) Next level postbiotics. https://lactosporin.com/lactosporin/next-level-postbiotics/. Accessed 29 March 2021
Salminen S, Collado MC, Endo A, Hill C, Lebeer S, Quigley EMM, Sanders ME, Shamir R, Swann JR, Szajewska H, Vinderola G (2021) The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol 18(9):649–667. https://doi.org/10.1038/s41575-021-00440-6
Sarikaya H, Aslim B, Yuksekdag Z (2017) Assessment of anti-biofilm activity and bifidogenic growth stimulator (BGS) effect of lyophilized exopolysaccharides (l-EPSs) from lactobacilli strains. Int J Food Prop 20(2):362–371. https://doi.org/10.1080/10942912.2016.1160923
Schnadower D, Tarr PI, Casper TC, Gorelick MH, Dean JM, O’Connell KJ, Mahajan P, Levine AC, Bhatt SR, Roskind CG, Powell EC, Rogers AJ, Vance C, Sapien RE, Olsen CS, Metheney M, Dickey VP, Hall-Moore C, Freedman SB (2018) Lactobacillus rhamnosus GG versus placebo for acute gastroenteritis in children. N Engl J Med 379(21):2002–2014. https://doi.org/10.1056/nejmoa1802598
Silab (n.d.) Lactobiotyl. Cosmetic. https://www.silab.fr/produit-108-lactobiotyl-cb_usa.html. Accessed 29 March 2021
SK-Bioland (n.d.) DERMABIOTICS. Technical Data Sheet. https://www.ulprospector.com/documents/1614856.pdf?bs=33934&b=3888091&st=1&r=eu&ind=personalcare. Accessed 12 August 2021
SK-Bioland (n.d.) LAVA-dermabiotics. Technical Data Sheet. https://www.ulprospector.com/documents/1614978.pdf?bs=33934&b=3979236&st=1&r=eu&ind=personalcare. Accessed 12 August 2021
Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermúdez-Humarán LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, Grangette C, Vasquez N, Pochart P, Trugnan G, Thomas G, Blottière HM, Doré J, Marteau P, Seksik P, Langella P (2008) Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci USA 105(43):16731–16736. https://doi.org/10.1073/pnas.0804812105
Souak D, Barreau M, Courtois A, André V, Poc CD, Feuilloley MGJ, Gault M (2021) Challenging cosmetic innovation: the skin microbiota and probiotics protect the skin from uv-induced damage. Microorganisms 9(5):936. https://doi.org/10.3390/microorganisms9050936
Suez J, Zmora N, Segal E, Elinav E (2019) The pros, cons, and many unknowns of probiotics. Nat Med 25(5):716–729. https://doi.org/10.1038/s41591-019-0439-x
Teame T, Wang A, **e M, Zhang Z, Yang Y, Ding Q (2020) Paraprobiotics and postbiotics of probiotic lactobacilli, their positive effects on the host and action mechanisms: a review. Front Nutr 7:570344. https://doi.org/10.3389/fnut.2020.570344
Tejada-Simon MV, Pestka JJ (1999) Proinflammatory cytokine and nitric oxide induction in murine macrophages by cell wall and cytoplasmic extracts of lactic acid bacteria. J Food Prot 62(12):1435–1444. https://doi.org/10.4315/0362-028X-62.12.1435
Tominari T, Sanada A, Ichimaru R, Matsumoto C, Hirata M, Itoh Y, Numabe Y, Miyaura C, Inada M (2021) Gram-positive bacteria cell wall-derived lipoteichoic acid induces inflammatory alveolar bone loss through prostaglandin E production in osteoblasts. Sci Rep 11(1):13353. https://doi.org/10.1038/s41598-021-92744-5
Transparency Market Research (n.d.) Postbiotic supplements market - global industry analysis, size, share, trends, growth, and forecasts, 2020 - 2030. https://www.transparencymarketresearch.com/postbiotic-supplements-market.html. Accessed 11 August 2021
Trif M, Schwarze AK, Bethke M, Penedo BA, Rusu A (2021) Individualized dietary supplements enriched with microbial propionic acid for athletes and the elderly with benefits on gut microbiota. Proceedings 66(1):23. https://doi.org/10.3390/proceedings2020066023
Tsilingiri K, Rescigno M (2013) Postbiotics: what else? Benef Microbes 4(1):101–107. https://doi.org/10.3920/BM2012.0046
Tsilingiri K, Barbosa T, Penna G, Caprioli F, Sonzogni A, Viale G, Rescigno M (2012) Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model. Gut 61(7):1007–1015. https://doi.org/10.1136/gutjnl-2011-300971
Vandenberghe LPS, Karp SG, de Oliveira PZ, de Carvalho JC, Rodrigues C, Soccol CR (2018) Solid-state fermentation for the production of organic acids. In Pandey A, Larroche C, Soccol C (eds) Current developments in biotechnology and bioengineering, 1st edn. Elsevier, pp 415–434. https://doi.org/10.1016/b978-0-444-63990-5.00018-9
Vidal K, Donnet-Hughes A, Granato D (2002) Lipoteichoic acids from Lactobacillus johnsonii strain La1 and Lactobacillus acidophilus strain La10 antagonize the responsiveness of human intestinal epithelial HT29 cells to lipopolysaccharide and gram-negative bacteria. Infect Immun 70(4):2057–2064. https://doi.org/10.1128/IAI.70.4.2057-2064.2002
Wang K, Niu M, Song D, Song X, Zhao J, Wu Y, Lu B, Niu G (2020a) Preparation, partial characterization and biological activity of exopolysaccharides produced from Lactobacillus fermentum S1. J Biosci Bioeng 129(2):206–214. https://doi.org/10.1016/j.jbiosc.2019.07.009
Wang S, Ahmadi S, Nagpal R, Jain S, Mishra SP, Kavanagh K, Zhu X, Wang Z, McClain DA, Kritchevsky SB, Kitzman DW, Yadav H (2020b) Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3–5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice. GeroScience 42(1):333–352. https://doi.org/10.1007/s11357-019-00137-4
Wee YJ, Ryu HW (2010) Production of organic acids. In Pandey A, Soccol CR, Larroche C, Gnansounou E, nee’Nigam PS (eds) Comprehensive food fermentation and biotechnology, vol II. Asiatech Publishers Inc, New Delhi, pp 774–794
Woresan (2021) WORESANA®rye. https://www.woresan.com/products/woresana-rye-active-ferment/. Accessed 29 March 2021
Yan F, Cao H, Cover TL, Whitehead R, Washington MK, Polk DB (2007) Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 132(2):562–575. https://doi.org/10.1053/j.gastro.2006.11.022
Yan F, Liu L, Dempsey PJ, Tsai YH, Raines EW, Wilson CL, Cao H, Cao Z, Liu L, Polk DB (2013) A Lactobacillus rhamnosus gg-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. J Biol Chem 288(42):30742–30751. https://doi.org/10.1074/jbc.m113.492397
Zhang S, Liu L, Su Y, Li H, Sun Q, Liang X, Lv J (2011) Antioxidative activity of lactic acid bacteria in yogurt. Afr J Microbiol Res 5(29):5194–5201. https://doi.org/10.5897/ajmr11.997
Żółkiewicz J, Marzec A, Ruszczyński M, Feleszko W (2020) Postbiotics—a step beyond pre-and probiotics. Nutrients 12(8):1–17. https://doi.org/10.3390/nu12082189
Žuntar I, Petric Z, Bursać Kovačević D, Putnik P (2020) Safety of probiotics: functional fruit beverages and nutraceuticals. Foods 9(7):947. https://doi.org/10.3390/foods9070947
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This paper was supported by Amyris Bio Products Portugal Unipessoal Lda and Escola Superior de Biotecnologia–Universidade Católica Portuguesa through Alchemy project – Capturing high value from industrial fermentation bio products (POCI-01–0247-FEDER-027578)
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Duarte, M., Oliveira, A.L., Oliveira, C. et al. Current postbiotics in the cosmetic market—an update and development opportunities. Appl Microbiol Biotechnol 106, 5879–5891 (2022). https://doi.org/10.1007/s00253-022-12116-5
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DOI: https://doi.org/10.1007/s00253-022-12116-5