Abstract
2,5-Furandicarboxylic acid (FDCA) is attracting increasing attention because of its potential applications as a sustainable substitute to petroleum-derived terephthalic acid for the production of bio-based polymers, such as poly(ethylene 2,5-furandicarboxylate) (PEF). Many catalytic methods have been developed for the synthesis of FDCA, including chemocatalysis, biocatalysis, photocatalysis, and electrocatalysis. Biocatalysis is a promising approach with advantages that include mild reaction condition, lower cost, higher selectivity, and environment amity. However, the biocatalytic production of FDCA has hardly been reviewed. To fully understand the current research developments, this review comprehensively considers the research progress on toxic effects and biodegradation of furan aldehydes, and then summarizes the latest achievements concerning the synthesis of FDCA from 5-hydroxymethylfurfural and other chemicals, such as 2-furoic acid and 5-methoxymethylfurfural. Our primary focus is on biocatalytic methods, including enzymatic catalysis (in vitro) and whole-cell catalysis (in vivo). Furthermore, future research directions and general developmental trends for more efficient biocatalytic production of FDCA are also proposed.
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References
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This work was supported by the National Natural Science Foundation of China (31501413); Shandong Key Project of Research & Development Plan (2017GSF221019); State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences (ZZ20190314); Young Doctorate Cooperation Fund Project, QiLu University of Technology (Shandong Academy of Sciences) (2017BSHZ021); Natural Science Foundation of Shandong Province (ZR2017BC072, ZR2019PC060); A Project of Shandong Province Higher Educational Science and Technology Program (A18KA116); and The Dragon City Excellent Researcher Award Program from Zhucheng and Taishan Industry Leading Talents Program.
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Yuan, H., Liu, H., Du, J. et al. Biocatalytic production of 2,5-furandicarboxylic acid: recent advances and future perspectives. Appl Microbiol Biotechnol 104, 527–543 (2020). https://doi.org/10.1007/s00253-019-10272-9
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DOI: https://doi.org/10.1007/s00253-019-10272-9