Abstract
A delicate balance exists between cell growth and cell death. In the context of the adult myocardium, inappropriate or inordinate cell loss through an apoptotic process may profoundly influence cardiac structure, function, or both given the limited and meager ability of the heart for repair after injury. Earlier work by the authors’ laboratory identified a close relation between cell cycle factor E2F-1 and hypoxia-inducible factor Bnip3 as the key regulator of apoptosis and autophagy in ventricular myocytes. Epigenetic changes by histone-modifying proteins, namely, histone deacetylases (HDACs) influence cell survival by altering the activity of histone core proteins, transcription factors, or both. This report highlights the intricate nature between the cellular factors E2F-1 and nuclear factor-κB (NF-κB) and the epigenetic regulation of Bnip3 gene transcription by HDAC1 for cell survival of ventricular myocytes.
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Acknowledgments
We thank Dr. Harvey Weisman and Ms. P. Lowe for critical comments on the manuscript. Lorrie A. Kirshenbaum is supported by grants from the CIHR and the Heart and Stroke Foundation. He holds a Canada Research Chair in Molecular Cardiology. Rimpy Dhingra is supported by an MHRC postdoctoral fellowship, and Joseph W. Gordon is supported by the CIHR IMPACT Strategic Training Program.
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Gang, H., Dhingra, R., Wang, Y. et al. Epigenetic Regulation of E2F-1-Dependent Bnip3 Transcription and Cell Death by Nuclear Factor-κB and Histone Deacetylase-1. Pediatr Cardiol 32, 263–266 (2011). https://doi.org/10.1007/s00246-011-9893-z
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DOI: https://doi.org/10.1007/s00246-011-9893-z