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The impact of metaphylaxis of kidney stone disease in the renal function at long term in active kidney stone formers patients

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Abstract

A total of 150 patients were included in the analysis. Through chart review, we estimated glomerular filtration rate in the first visit and, at least, 5 years later. All patients were divided into two groups: (1) metaphylaxis adherents (n = 74) and (2) metaphylaxis non-adherents (n = 76). We followed all patients for at least 5 years. The Scr percentage of patients and GFR <60 mL/min was compared between groups. Variables were compared between groups using t test, χ2 tests, odds ratios with 95% confidence intervals. There were no differences at baseline between groups. After 5 years of follow-up, GFR was 77.9 mL/min in non-adherent-metaphylaxis group and in the adherent-metaphylaxis group was 87.3 mL/min, with p value of 0.02. After 5 years of follow-up, we had a GFR <60 mL/min in the adherent-metaphylaxis group (4.89 vs. 21.95%) with p value of 0.001 and OR = 5.36; IC-95% = 1.95–14.8. Metaphylaxis of kidney stone disease could prevent chronic kidney disease.

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References

  1. Curhan GC (2007) Epidemiology of stone disease. Urol Clin North Am 34(3):287–293

    Article  PubMed  Google Scholar 

  2. Romro V, Akpinar H, Assinos DG (2010) Kidney stones: a global picture of prevalence, incidence, and associated risk factors. Rev Urol 12(2–3):e86–e96

    Google Scholar 

  3. Lieske JC, Peja de la Vega LS, Slezak JM, Bergstralh EJ, Leibson CL, Ho KL, Gettman MT (2006) Renal stone epidemiology in Rochester, Minnesota: an update. Kidney Int 69(4):760–764

    Article  PubMed  CAS  Google Scholar 

  4. Stamatelou KK, Francis ME, Jones CA et al (2003) Time trends in reported prevalence of kidney stones in the United States: 1976–1994. Kidney Int 63:1817–1823

    Article  PubMed  Google Scholar 

  5. Frymoyer PA, Scheinman SJ, Dunhan DB, Jones DB, Hueben P, Schoroeder ET (1991) X-linked recessive nephrolithiasis with renal failure. N Engl J Med 325(10):681–686

    Article  PubMed  CAS  Google Scholar 

  6. Leumann EP (1985) Primary hyperoxaluria: an important cause of renal failure in infancy. Int J Pediatr Nephrol 6(1):13–16

    PubMed  CAS  Google Scholar 

  7. De Walter R, Noordermeer C, Nizze H, Schröder FH, Kok DJ (1999) Calcium oxalate nephrolithiasis: the significance of monocytes and macrophages. In: Borghi L, Meschi T, Briganti A, Schianchi T, Novarini (eds) Kidney stones, proceedings of the European symposium on urolithiasis, Parma, Italy, editoriale bios, pp 329–333

  8. Toblli EJ, Romano L, Nyberg C, Angerosa M, Pagano P, Ferder L, Inserra F (1996) Renal tubulointersticial (TI) protection in hyperoxaluric (Hox) rats. J Am Soc Nephrol 6:1748A (abstract)

    Google Scholar 

  9. Holmes MS, Lieske JC, Pawar S, Spargo BH, Toback FG (1995) Calcium oxalate monohydrate crystals stimulate gene expression in renal epithelial cells. Kidney Int 48:501–509

    Article  Google Scholar 

  10. Koul H, Kennington L, Honeyman T, Jonassenn J, Menon M, Scheid C (1996) Activation of c-myc gene expression in renal epithelial cells in LLC-PK1 cell, a line of renal epithelial cells. Kidney Int 50:1525–1530

    Article  PubMed  CAS  Google Scholar 

  11. Lieske JC, Hammes MS, Hoyer JR, Toback G (1997) Renal cell osteopontin production is stimulated by calcium oxalate monohydrate crystals. Kidney Int 51:679–686

    Article  PubMed  CAS  Google Scholar 

  12. Koten JW, Van Gastel C, Dorhoutmees EJ, Holleman LWJ, Schuiling RD (1965) Two cases of primary oxalosis. J Clin Pathol 18:223–229

    Article  PubMed  CAS  Google Scholar 

  13. Lieske JC, Spargo BH, Toback G (1992) Endocytosis of calcium oxalate crystals and proliferation of renal tubular epithelial cells in a with type 1 primary hyperoxaluria. J Urol 148:1517–1519

    PubMed  CAS  Google Scholar 

  14. Goswami A, Singhal PC, Wagner JD, Urivetky M, Valderrama E, Smith AD (1995) Matrix modulates uptake of calcium oxalate crystals and cell growth of renal epithelial cells. J Urol 153:206–211

    Article  PubMed  CAS  Google Scholar 

  15. Lieske JC, Toback FG (1996) Interaction of urinary crystals with renal epithelial cells en the pathogenesis of nephrolithiasis. Semin Nephrol 16:458–473

    PubMed  CAS  Google Scholar 

  16. Scheid CR, Koul H, Hill WA, Luber-Narod J, Kenington L, Honeyman T, Jonassen J, Menon M (1996) Oxalate toxicity in LLC-PK1 cells: role of free radicals. Kidney Int 49:413–419

    Article  PubMed  CAS  Google Scholar 

  17. Hosking DH, Erickson SB, Van den Berg CJ, Wilson DM, Smith LH (1983) The stone clinic effect in patients with idiopathic calcium urolithiasis. J Urol 130(6):1115–1118

    PubMed  CAS  Google Scholar 

  18. Borghi L, Schianchi T, Meschi T, Guerra A, Allegri F, Maggiore U, Novarini A (2002) Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med 346(2):77–84

    Article  PubMed  CAS  Google Scholar 

  19. Ettinger B, Citron JT, Livermore B, Dolman LI (1988) Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol 139(4):679–684

    PubMed  CAS  Google Scholar 

  20. Nijenhuis T, Hoenderop JG, Loffing J, van der Kemp AW, van Os CH, Bindels RJ (2003) Thiazide-induced hypocalciuria is accompanied by a decreased expression of Ca2+ transport proteins in kidney. Kidney Int 64(2):555–564

    Article  PubMed  CAS  Google Scholar 

  21. Ettinger B, Tang A, Citron JT, Livermore B, Williams T (1986) Randomized trial of allopurinol in the prevention of calcium oxalate calculi. N Engl J Med 315(22):1386–1389

    Article  PubMed  CAS  Google Scholar 

  22. Favus MJ, Coe FL (1980) The effects of allopurinol treatment on stone formation on hyperuricosuric calcium oxalate stone-formers. Scand J Urol Nephrol Suppl 53:265–271

    PubMed  CAS  Google Scholar 

  23. Barcelo P, Wuhl O, Servitge E, Rousaud A, Pak CY (1993) Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis. J Urol 150(6):1761–1764

    PubMed  CAS  Google Scholar 

  24. Coe FL, Parks JH, Asplin JR (1992) The pathogenesis and treatment of kidney stones. N Engl J Med 327(16):1141–1152

    Article  PubMed  CAS  Google Scholar 

  25. Vupputuri S, Soucie M, Mcclellan W, Sandler DP (2004) History of kidney stones as a possible factor for chronic kidney disease. AEP 14(3):222–228

    PubMed  Google Scholar 

  26. Jungers P, Joly D, Barbey F, Choukroun G, Daudon M (2004) ESRD caused by nephrolithiasis: prevalence, mechanisms, and prevention. Am J Kidney Dis 44(5):799–805

    PubMed  Google Scholar 

  27. Pyrah LN (1979) Renal calculus. Springer, Berlin, pp 27–28

    Book  Google Scholar 

  28. Larssom PA, Cano M, Grenabo L, Brorson J-E, Hederlin H, Petersson S, Johansson SL (1989) Morphological lesions or rat urinary tract pathogens. Urol Int 44:210–217

    Article  Google Scholar 

  29. Braude AI, Siemenski I (1960) Role of bacterial urease in experimental pyelonephritis. J Bacteriol 80:171–179

    PubMed  CAS  Google Scholar 

  30. Mac Laren DM, Peerbooms PGH (1986) Urinary infection by urea splitting microorganism. In: Asscher AW, Brumfitt W (eds) Microbial diseases in nephrology. Wiley, New York

    Google Scholar 

  31. Koga S, Arakaki Y, Matsuoka M, Ohyma C (1991) Staghorn calculi: long term results of management. Br J Urol 68:122–124

    Article  PubMed  CAS  Google Scholar 

  32. Igarashi T, Hayakawa H, Shiraga H, Kawato H, Yan K, Kawaguchi H, Yamanaka T, Tsuchida S, Akagi K (1995) Hypercalciuria and nephrocalcinosis in patients with idiopathic low-molecular-weight proteinuria in Japan: is disease identical to Dent’s disease in United Kingdom. Nephron 69:242–247

    Article  PubMed  CAS  Google Scholar 

  33. Khan SR (2010) Nephrocalcinosis in animal models with and without stones. Urol Res 38(6):429–438

    Article  PubMed  Google Scholar 

  34. Sakhaee K (2008) Nephrolithiasis as a systemic disorder. Curr Opin Nephrol Hypertens 17:304–309

    Article  PubMed  Google Scholar 

  35. Evan AP, Coe FL, Lingeman JE, Worcester E (2005) Insights on the pathology of kidney stone formation. Urol Res 33(5):333–389

    Article  Google Scholar 

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Authors and Affiliations

  1. Nephrologist of Clinic Stone Lithocentro, Rua Piauí 179, Belo Horizonte, MG, CEP 30-320-150, Brazil

    Jose A. Meneses, Fernando M. Lucas & Fernando C. Assunção

  2. Biochemistry of Clinical Pathology Laboratory, Paula Castro, Avenida Pasteur 106, Belo Horizonte, MG, CEP 30-150-290, Brazil

    Junia P. P. Castro & Rogério B. Monteiro

Authors
  1. Jose A. Meneses
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  2. Fernando M. Lucas
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  3. Fernando C. Assunção
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  4. Junia P. P. Castro
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  5. Rogério B. Monteiro
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Correspondence to Jose A. Meneses.

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Meneses, J.A., Lucas, F.M., Assunção, F.C. et al. The impact of metaphylaxis of kidney stone disease in the renal function at long term in active kidney stone formers patients. Urol Res 40, 225–229 (2012). https://doi.org/10.1007/s00240-011-0407-5

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  • DOI: https://doi.org/10.1007/s00240-011-0407-5

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