Abstract.
We report a cross-sectional study of 48 men, 56 premenopausal women, and 80 postmenopausal women who were of three ethnic/regional backgrounds: southern European (Greek, Italian), eastern European (Jewish, Polish, Hungarian), and western European (French, British). We determined bone mineral density (BMD) at four skeletal sites and assessed the vitamin D receptor (VDR) genotype by the Bsml restriction site polymorphism. Age and body mass index had significant effects on BMD by multiple regression analysis. In addition, ethnic/regional group had a significant effect on spinal BMD in premenopausal females (P= 0.014) and in males (P= 0.039). However, VDR genotype had no significant effect on BMD in any of the three study groups.
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Received: 4 December 1995 / Accepted: 27 March 1996
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Spotila, L., Caminis, J., Johnston, R. et al. Vitamin D Receptor Genotype is Not Associated with Bone Mineral Density in Three Ethnic/Regional Groups. Calcif Tissue Int 59, 235–237 (1996). https://doi.org/10.1007/s002239900114
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DOI: https://doi.org/10.1007/s002239900114