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In search of lost presynaptic inhibition

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Abstract

This chapter presents an historical review on the development of some of the main findings on presynaptic inhibition. Particular attention is given to recent studies pertaining the differential GABAa control of the synaptic effectiveness of muscle, cutaneous and articular afferents, to some of the problems arising with the identification of the interneurons mediating the GABAergic depolarization of primary afferents (PAD) of muscle afferents, on the influence of the spontaneous activity of discrete sets of dorsal horn neurons on the pathways mediating PAD of muscle and cutaneous afferents, and to the unmasking of the cutaneous-evoked responses in the lumbosacral spinal cord and associated changes in tonic PAD that follow acute and chronic section of cutaneous nerves. The concluding remarks are addressed to several issues that need to be considered to have a better understanding of the functional role of presynaptic inhibition and PAD on motor performance and sensory processing and on their possible contribution to the sha** of a higher coherence between the cortically programmed and the executed movements.

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Acknowledgments

I want to thank Dr. I. Jiménez, D. Chávez and C. García for allowing the use of the material illustrated in Figs. 1, 2, 3 and 4, to C. León for technical assistance and to E. Velázquez and P. Reyes for programming. This work was partly supported by NIH grant NS 09196 and by CONACyT grant 50900.

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  1. Department of Physiology, Biophysics and Neurosciences, Center for Research and Advanced Studies, IPN, Mexico, Mexico

    Pablo Rudomin

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Rudomin, P. In search of lost presynaptic inhibition. Exp Brain Res 196, 139–151 (2009). https://doi.org/10.1007/s00221-009-1758-9

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