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SPR-based biosensors: a tool for biodetection of hormonal compounds

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Abstract

Novel cancer treatments, prevention of postmenopausal disorder, and prescription of oral contraceptives are the main developments in the design of synthetic estrogenic medication. The increasing consumption of these synthetic pharmaceuticals, in addition to human and animal natural estrogenic compound excretion, contribute to their environmental dissemination worldwide. Their assimilation as a result of consumption of food and water perturbs normal endocrine systems and leads to the emergence of human and animal diseases and malformations. These compounds are active in the organism at low concentrations. Accordingly, daily low-level exposure disrupts the natural equilibrium in the endocrine system. A method enabling quantification at such products at low levels (from pg L−1 to ng L−1) is therefore required for these products. Surface plasmon resonance, essentially used for comprehension of molecular mechanisms and in drug discovery, can also be used for environmental pollutant monitoring. This technology has already been used for evaluation of the effects of chemical pollutants on specific nuclear receptors. It has been possible to determine the role of each individual compound on the disruption of the estrogen-activated cellular pathway. Development of SPR screening methods enables application of such an approach for quantification of these compounds in water.

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Abbreviations

BSA:

bovine serum albumin

E2:

17β-Estradiol

EDC:

endocrine disruptor compounds

ER:

estrogen receptor

ERE:

estrogen response element

SPR:

surface plasmon resonance

mAb:

monoclonal antibody

LBD:

ligand-binding domain

PAH:

polycyclic aromatic hydrocarbons

WWTP:

wastewater-treatment plants

RU:

resonance unit

SERM:

selective estrogen receptor modulators

SPE:

solid-phase extraction

GC:

gas chromatography

LC:

liquid chromatography

MS:

mass spectrometry

SBSE:

stir-bar sorptive extraction

E3G:

estrone-3-glucuronide

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Authors and Affiliations

  1. Centre LGEI, Ecole des Mines d’Alès, 6 avenue de Clavières, 30319, Alès Cedex, France

    Denis Habauzit & Benoit Roig

  2. Unité de recherche JE 2470 ADONIM, Centre Universitaire de Formation et de Recherche de Nîmes, Site des Carmes, Place Gabriel Péri, 30021, Nîmes Cedex 01, France

    Denis Habauzit, Joel Chopineau & Benoit Roig

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  1. Denis Habauzit
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  2. Joel Chopineau
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  3. Benoit Roig
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Correspondence to Benoit Roig.

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Habauzit, D., Chopineau, J. & Roig, B. SPR-based biosensors: a tool for biodetection of hormonal compounds. Anal Bioanal Chem 387, 1215–1223 (2007). https://doi.org/10.1007/s00216-006-0958-4

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