Abstract
Rationale
It has been suggested that caffeine is most likely to benefit mood and performance when alertness is low.
Objectives
To measure the effects of caffeine on psychomotor and cognitive performance, mood, blood pressure and heart rate in sleep-restricted participants. To do this in a group of participants who had also been previously deprived of caffeine for 3 weeks, thereby potentially removing the confounding effects of acute caffeine withdrawal.
Methods
Participants were moderate to moderate–high caffeine consumers who were provided with either decaffeinated tea and/or coffee for 3 weeks (LTW) or regular tea and/or coffee for 3 weeks (overnight caffeine-withdrawn participants, ONW). Then, following overnight caffeine abstinence, they were tested on a battery of tasks assessing mood, cognitive performance, etc. before and after receiving caffeine (1.2 mg/kg) or on another day after receiving placebo.
Results
Final analyses were based on 17 long-term caffeine-withdrawn participants (LTW) and 17 ONW participants whose salivary caffeine levels on each test day confirmed probable compliance with the instructions concerning restrictions on consumption of caffeine-containing drinks. Acute caffeine withdrawal (ONW) had a number of negative effects, including impairment of cognitive performance, increased headache, and reduced alertness and clear-headedness. Caffeine (versus placebo) did not significantly improve cognitive performance in LTW participants, although it prevented further deterioration of performance in ONW participants. Caffeine increased tap** speed (but tended to impair hand steadiness), increased blood pressure, and had some effects on mood in both groups.
Conclusions
The findings provide strong support for the withdrawal reversal hypothesis. In particular, cognitive performance was found to be affected adversely by acute caffeine withdrawal and, even in the context of alertness lowered by sleep restriction, cognitive performance was not improved by caffeine in the absence of these withdrawal effects. Different patterns of effects (or lack of effects) of caffeine and caffeine withdrawal were found for other variables, but overall these results also suggest that there is little benefit to be gained from caffeine consumption.
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References
Arnold RW, Springer DT, Engel WK, Helveston EM (1993) The effect of wrist rest, caffeine, and oral timolol on the hand steadiness of ophthalmologists. Ann Ophthalmol 25:250–253
Baddeley AD (1999) Essentials of human memory. Psychology Press, Hove
Bovim G, Naess P, Helle J, Sand T (1995) Caffeine influence on the motor steadiness battery in neuropsychological tests. J Clin Exp Neuropsychol 17:472–476
Broadbent DE, Broadbent HP, Jones JJ (1989) Time of day as an instrument for the analysis of attention. Eur J Cogn Psychol 1:69–94
Bruce M, Scott N, Shine P, Lader M (1991) Caffeine withdrawal: a contrast of withdrawal symptoms in normal subjects who have abstained from caffeine for 24 hours and for 7 days. J Psychopharmacol 5:129–134
Dawson EL, Dennison EHL, van Weeman BK (1978) A simple and efficient method for raising steroid antibodies in rabbits. Steroids 31:357–366
Eriksen BA, Eriksen CW (1974) Effects of noise letters upon identification of target in a non-search task. Percept Psychophys 16:143–149
Erlanger B, Borek F, Beiser SM, Lieberman S (1957) Preparation and characterisation of conjugates of bovine serum albumin with testosterone and with cortisone. J Biol Chem 228:713–727
Goldstein A, Kaizer S, Whitby O (1969) Psychotropic effects of caffeine in man. IV. Quantitative and qualitative differences associated with habituation to coffee. Clin Pharmacol Ther 10:489–497
Horne JA, Reyner LA (1996) Counteracting driver sleepiness: effects of nap**, caffeine and placebo. Psychophysiology 33:306–309
James JE (1990) The influence of user status and anxious disposition on the hypertensive effects of caffeine. Int J Psychophysiol 10:171–179
James JE (1994) Does caffeine enhance or merely restore degraded performance? Neuropsychobiology 30:124–125
James JE (1997) Understanding caffeine: a biobehavioral analysis. Sage, Thousand Oaks, CA
James JE (1998) Acute and chronic effects of caffeine on performance, mood, and sleep. Neuropsychobiology 38:32–41
Johnson LC, Spinweber CL, Gomez SA, Matteson LT (1990) Daytime sleepiness, performance, mood, nocturnal sleep: the effect of benzodiazepine and caffeine on their relationship. Sleep 13:121–135
Leark RA, Dupuy T, Greenberg L, Corman C, Kindschi C (1996) Test of variables of attention: professional manual. Universal Attention Disorders, Los Alamitos, CA
Lieberman HR, Wurtman RJ, Emde GG, Roberts C, Coviella ILG (1987) The effects of low doses of caffeine on human performance and mood. Psychopharmacology 92:308–312
Lieberman HR, Tharion WJ, Shukitt-Hale B, Speckman KL, Tulley R (2002) Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Psychopharmacology 164:250–261
Lorist MM, Snel J, Kok A (1994) Influence of caffeine on information processing in well rested and fatigued subjects. Psychopharmacology 113:411–421
Miller LS, Lombardo TW, Fowler SC (1998) Caffeine, but not time of day, increases whole-arm physiological tremor in non-smoking moderate users. Clin Exp Pharmacol Physiol 25:131–133
Reyner LA, Horne JA (2002) Efficacy of a ‘functional energy drink’ in counteracting driver sleepiness. Physiol Behav 75:331–335
Richardson NJ, Rogers PJ, Elliman NA, O’Dell RJ (1995) Mood and performance effects of caffeine in relation to acute and chronic caffeine deprivation. Pharmacol Biochem Behav 52:313–320
Rogers PJ, Dernoncourt C (1998) Regular caffeine consumption: a balance of adverse and beneficial effects for mood and psychomotor performance. Pharmacol Biochem Behav 59:1039–1045
Rogers PJ, Stephens S, Day JEL (1998) Contrasting performance effects of caffeine after overnight and chronic caffeine withdrawal. J Psychopharmacol 12:A13
Rogers PJ, Martin J, Smith C, Heatherley SV, Smit HJ (2003) Absence of reinforcing, mood and psychomotor performance effects of caffeine in habitual non-consumers of caffeine. Psychopharmacology 167:54–62
Smit HJ, Rogers PJ (2000) Effects of low doses of caffeine on cognitive performance, mood and thirst in low and higher caffeine consumers. Psychopharmacology 152:167–173
Smit HJ, Rogers PJ (2002) Effects of caffeine on mood. Pharmacopsychoecologia 15:231–257
Smith AP, Maben A, Brockman P (1994) Effects of evening meals and caffeine on cognitive performance, mood and cardiovascular functioning. Appetite 22:57–65
Warburton DM (1995) Effects of caffeine on cognition and mood without caffeine abstinence. Psychopharmacology 119:66–70
Warburton DM, Bersellini E (2001) An evaluation of a caffeinated taurine drink on mood, memory and information processing in healthy volunteers without caffeine abstinence. Psychopharmacology 158:322–328
Wesensten NJ, Belenky G, Kautz MA, Thorne DR, Reichardt RM, Balkin TJ (2002) Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine. Psychopharmacology 159:238–247
Acknowledgements
This research was supported by a grant from the European Union Fifth Framework Programme (grant no. QLK1-2000-00069). The views expressed in this paper are the sole responsibility of the authors and do not necessarily reflect the views of the European Commission or its services or their future policy in this area.
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Rogers, P.J., Heatherley, S.V., Hayward, R.C. et al. Effects of caffeine and caffeine withdrawal on mood and cognitive performance degraded by sleep restriction. Psychopharmacology 179, 742–752 (2005). https://doi.org/10.1007/s00213-004-2097-y
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DOI: https://doi.org/10.1007/s00213-004-2097-y