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Risedronate reduces postoperative bone resorption after cementless total hip arthroplasty

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Abstract

Summary

Forty-three patients who had undergone cementless THA were randomly assigned to receive no osteoactive drug or oral risedronate for 6 months. Postoperative decrease of BMD in the risedronate group was significantly lower than that seen in the control group in zones 1, 2, 3, 6, and 7.

Introduction

Proximal bone resorption around the femoral stem often has been observed after total hip arthroplasty (THA), could lead to late stem loosening. We previously reported the efficacy of etidronate on periprosthetic bone resorption after cementless THA. Recently risedronate is suggested to be effective for the prevention and treatment of for osteoporosis. The purpose of the present study was to evaluate the effects of risedronate on periprosthetic bone loss after cementless THA.

Methods

Forty-three patients who had undergone cementless THA were randomly assigned to receive no osteoactive drug (21 patients) or oral risedronate 2.5 mg/day (22 patients) for 6 months. Three patients were eliminated from the risedronate group because of dyspepsia. Periprosthetic bone mineral density (BMD) in seven regions of interest based on the zones of Gruen et al. was measured with dual energy X-ray absorptiometry at 3 weeks and 6 months postoperatively.

Results

At 6 months after surgery, postoperative decrease of BMD in the risedronate group was significantly lower than that seen in the control group in zones 1, 2, 3, 6, and 7 (p < 0.05, p < 0.01, p < 0.01, p < 0.05, and p < 0.05, respectively).

Conclusion

These outcomes suggested that risedronate might reduce the periprosthetic bone resorption after cementless THA.

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Acknowledgements

The authors wish to gratefully acknowledge Masazumi Notou for technical assistance.

This study is based on data collected in Osaka Kosei-Nenkin Hospital.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Nishinomiya Municipal Central Hospital, 8-24, Hayashida-cho, Nishinomiya, 663-8014, Hyogo, Japan

    S. Yamasaki

  2. Department of Orthopaedic Surgery, Osaka Kosei-Nenkin Hospital, Osaka, Japan

    K. Masuhara & T. Fuji

  3. Yamaguchi Orthopaedic Clinic, Osaka, Japan

    K. Yamaguchi

  4. Department of Orthopaedic Surgery, Osaka Police Hospital, Osaka, Japan

    T. Nakai

  5. Osaka Kosei-Nenkin Hospital, Osaka, Japan

    Y. Seino

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  1. S. Yamasaki
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  2. K. Masuhara
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  3. K. Yamaguchi
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  4. T. Nakai
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  5. T. Fuji
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Correspondence to S. Yamasaki.

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Yamasaki, S., Masuhara, K., Yamaguchi, K. et al. Risedronate reduces postoperative bone resorption after cementless total hip arthroplasty. Osteoporos Int 18, 1009–1015 (2007). https://doi.org/10.1007/s00198-007-0339-7

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  • DOI: https://doi.org/10.1007/s00198-007-0339-7

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